The role of the growth conditions in the spin transport properties of silver (Ag) have been studied by using lateral spin valve structures. By changing the deposition conditions of Ag from polycrystalline to epitaxial growth, we have observed a considerable enhancement of the spin diffusion length, from ! !" = 449 ± 30 to 823 ± 59 nm. This study shows that diminishing the grain boundary contribution to the spin relaxation mechanism is an effective way to improve the spin diffusion length in metallic nanostructures.A new generation of spintronic devices, which rely only on the electron spin degree of freedom, are envisioned towards a future integration of logics and memory [1]. Creation, transport and detection of a pure spin current, i.e., a flow of spin angular momentum without being accompanied by a charge current, are thus essential ingredients for a successful device. Lateral spin valves (LSVs) are basic spintronic devices that offer an attractive means to study the spin transport as well as the spin injection properties in different materials. After the pioneering studies, first by Johnson and Silsbee [2,3] and more recently by Jedema et al. [4,5], a large number of spin injection experiments have been reported in metals [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22], semiconductors [23,24] or carbon-based materials [25,26]. LSVs consist of two ferromagnetic (FM) electrodes, used to inject and detect pure spin currents, bridged by a non-magnetic (NM) channel, which transports the injected spin current (see Fig. 1(a)). For the optimum performance of a LSV, it is crucial to choose a NM material in which the spin information can travel over long distances, i.e. with long spin diffusion length λ NM , with Cu [4-12], Al [2,5,9,13,14] or Ag [15][16][17][18][19][20][21][22] being the most commonly selected metals. In order to enhance λ NM , it is crucial to understand which are the spin relaxation processes that lead to the loss of spin information. It is known that, in NM metals, the spin relaxation is governed by the Elliott-Yafet (EY) mechanism [27,28], with phonons, grain boundaries, impurities or the surface being common sources for the associated spin-flip scattering [5,7,12,18,19]. A proper control of these contributions could thus help obtaining longer λ NM values.In this work, we explore a way of diminishing the grain boundary contribution to the spin relaxation by controlling the growth conditions of Ag. For this purpose, we have