Enhanced spatial resolution in optical imaging of biotissues labelled with upconversion nanoparticles using a fibre-optic probe scanning technique

Khaydukov, E. V.; Семчишен, В. А.; Семиногов, В. Н.; Sokolov, V. I.; Попов, А. П.; Bykov, Alexander; Нечаев, А. В.; Akhmanov, A. S.; Panchenko, V. Ya.; Zvyagin, Andrei V.

doi:10.1088/1612-2011/11/9/095602

Cited by 16 publications

(4 citation statements)

References 28 publications

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“…Although small molecules are able to travel easily within the body and often can enter cells (or can be redesigned to do so), unlike nanomaterials they are not able to deliver a large payload, cannot be easily multiplexed, typically cannot be combined with therapeutics (e.g., theranostic strategies), and cannot be so precisely nor easily engineered. To compete effectively with small-molecule agents, nanomaterials/nanoparticles must pose no increased safety risk (a potentially critical limitation for some nanomaterials , ) while providing at least one substantial advantage such as increased imaging sensitivity, improved resolution, multiplexing capability, etc.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials for In Vivo Imaging

Gambhir²

2017

Chem. Rev.

916

718

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In vivo imaging, which enables us to peer deeply within living subjects, is producing tremendous opportunities both for clinical diagnostics and as a research tool. Contrast material is often required to clearly visualize the functional architecture of physiological structures. Recent advances in nanomaterials are becoming pivotal to generate the high-resolution, high-contrast images needed for accurate, precision diagnostics. Nanomaterials are playing major roles in imaging by delivering large imaging payloads, yielding improved sensitivity, multiplexing capacity, and modularity of design. Indeed, for several imaging modalities, nanomaterials are now not simply ancillary contrast entities, but are instead the original and sole source of image signal that make possible the modality's existence. We address the physicochemical makeup/design of nanomaterials through the lens of the physical properties that produce contrast signal for the cognate imaging modality-we stratify nanomaterials on the basis of their (i) magnetic, (ii) optical, (iii) acoustic, and/or (iv) nuclear properties. We evaluate them for their ability to provide relevant information under preclinical and clinical circumstances, their in vivo safety profiles (which are being incorporated into their chemical design), their modularity in being fused to create multimodal nanomaterials (spanning multiple different physical imaging modalities and therapeutic/theranostic capabilities), their key properties, and critically their likelihood to be clinically translated.

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Section: Introductionmentioning

confidence: 99%

Nanomaterials for In Vivo Imaging

Gambhir²

2017

Chem. Rev.

916

718

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“…The Upconverting nanoparticles can be produced by various methods [19,20]. We developed a method of synthesis of upconverting nanoparticles that renders possible to obtain monodisperse particles of NaYF 4 :M (М = Yb 3+ :Er 3+ ) with a high conversion yield [21]. Oxides Y 2 O 3 , Yb 2 O 3 , and Er 2 O 3 were boiled together in TFA-H 2 O (3:1 vol.…”

Section: Resultsmentioning

confidence: 99%

New Cysteine-Containing PEG-Glycerolipid Increases the Bloodstream Circulation Time of Upconverting Nanoparticles

et al. 2022

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Upconverting nanoparticles have unique spectral and photophysical properties that make them suitable for development of theranostics for imaging and treating large and deep-seated tumors. Nanoparticles based on NaYF4 crystals doped with lanthanides Yb3+ and Er3+ were obtained by the high-temperature decomposition of trifluoroacetates in oleic acid and 1-octadecene. Such particles have pronounced hydrophobic properties. Therefore, to obtain stable dispersions in aqueous media for the study of their properties in vivo and in vitro, the polyethylene glycol (PEG)-glycerolipids of various structures were obtained. To increase the circulation time of PEG-lipid coated nanoparticles in the bloodstream, long-chain substituents are needed to be attached to the glycerol backbone using ether bonds. To prevent nanoparticle aggregation, an L-cysteine-derived negatively charged carboxy group should be included in the lipid molecule.

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“…Unique UCNP properties provide NIR-tovisible and NIR-to-NIR luminescence suitable for bioimaging (Kobayashi et al, 2009), long-term visualization implemented even at the level of single NP (Liu et al, 2018), and the excellent excitation depth in biological tissue of up to 1 cm (Zhan et al, 2013). In addition, UCNPs are characterized by superior photostability, non-blinking (Wu et al, 2009), long lifetimes (Zhan et al, 2013;Pilch et al, 2017), low cytotoxicity (Guller et al, 2015(Guller et al, , 2018Vedunova et al, 2016), and high spatial resolution during bioimaging (Zhan et al, 2011;Chen et al, 2012;Xu et al, 2013;Khaydukov et al, 2014;González-Béjar et al, 2016;Generalova et al, 2017).…”

Section: Introductionmentioning

confidence: 99%