Enhanced serum levels of thiobarbituric-acid-reactive substances in diabetes mellitus

Griesmacher, Andrea; Kindhauser, Marlene; Andert, Sylvia; Schreiner, Wolfgang; Toma, Cyril D.; Knöbl, Paul; Pietschmann, Péter; Prager, Rudolf; Schnack, Ch.; Schemthaner, Guntram; Mueller, Mathias M.

doi:10.1016/s0002-9343(99)80347-7

Cited by 259 publications

(156 citation statements)

References 20 publications

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“…Some investigators have reported an association between TBARS and diabetic complications [16,18] while other have not [14]. Jennings et al [41] reported that elevated levels of conjugated dienes in plasma from diabetic subjects are associated with microangiopathy.…”

Section: Discussionmentioning

confidence: 99%

“…This problem has been approached in two ways: 1) measurement of reaction products of oxidative damage such as lipid peroxides; and 2) measurement of the depletion of antioxidants. Enhanced lipid peroxidation in diabetic patients has been reported using thiobarbituric acid reactive substances (TBARS) as an assay [14][15][16][17][18]. However, interpretation of the relationship between lipid peroxidation and diabetes has yielded contradictory results [14,15,18,19].…”

Section: © Springer-verlag 1997mentioning

confidence: 99%

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Relationships between plasma measures of oxidative stress and metabolic control in NIDDM

et al. 1997

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Section: Discussionmentioning

confidence: 99%

Section: © Springer-verlag 1997mentioning

confidence: 99%

Relationships between plasma measures of oxidative stress and metabolic control in NIDDM

et al. 1997

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“…Enhanced oxidative stress, as monitored by increased levels of plasma hydroperoxides [20][21][22][23][24] and increased susceptibility of LDL to oxidation, has already been reported in diabetic patients [24,29]. In diabetic patients in poor control, excess glucose causes an enhancement of the glycation of plasma protein and this non-enzymatic glycation of proteins has been presumed to cause enhanced oxidative stress, through generation of oxygen free radicals [16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

“…This non-enzymatic glycation of proteins has been presumed to cause an enhanced oxidative stress, through generation of oxygen free radicals [16][17][18][19]. An enhanced oxidative stress, i. e. increased levels of plasma hydroperoxides, has actually been observed in NIDDM [20][21][22][23][24]. The augmented generation of free radicals could also result in oxidative damage of LDL, the known potentially atherogenic properties of oxidized LDL including monocyte recruitment [25] and modulation of expression of adhesion molecules [26,27].…”

mentioning

confidence: 99%

E-Selectin plasma concentration is influenced by glycaemic control in NIDDM patients: possible role of oxidative stress

Cominacini¹,

Pasini²,

Garbin³

et al. 1997

Diabetologia

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Atherosclerosis is the major cause of death in patients with diabetes mellitus, accounting for more than 70 % of mortality in all forms of the disease [1,2]. There is plenty of evidence that monocytes are involved in the pathogenesis of atherosclerosis [3,4], the earliest morphological evidence of the disease being the binding of monocytes to the endothelium [5][6][7]. This adhesion of monocytes, a prerequisite for their recruitment and accumulation in the lesion, is probably due to the appearance of adhesion Diabetologia (1997) Summary Although elevated levels of soluble E-selectin and intercellular cell adhesion molecules-1 (ICAM-1) have been reported in non-insulin-dependent diabetes mellitus (NIDDM), it is not clear by what mechanism this elevation occurs and whether or not it is related to glycaemic control. In this study we analyse: 1) the relation of glycaemic control with the concentrations of E-selectin, vascular cell adhesion molecules-1 (VCAM-1) and ICAM-1 in NIDDM patients; 2) whether metabolic control can affect the oxidative stress (as measured by plasma hydroperoxide concentration and susceptibility of LDL to in vitro oxidation) and hence the adhesion molecule plasma concentrations. Thirty-four (19 males and 15 females) poorly controlled NIDDM patients were studied. All parameters were evaluated at the beginning of the study and after 90 days of dietary and pharmacological treatment. The treatment decreased HbA 1C (p < 0.001), E-selectin (p < 0.001), plasma hydroperoxides (p < 0.003) and the susceptibility of LDL to in vitro oxidation (lag phase) (p < 0.0001). Before treatment HbA 1C , lag phase and lipid hydroperoxides correlated with E-selectin plasma concentration (r = 0.51, -0.57 and 0.54, respectively, p < 0.01). There was also a correlation between HbA 1C and lag phase (p < 0.01) and between HbA 1C and lipid hydroperoxides (p < 0.01). In addition, the variations of HbA 1C , lag phase and lipid hydroperoxide values correlated with those for E-selectin concentration after 90 days' treatment (r = 0.54, -0.64 and 0.61, respectively, p < 0.01). In multiple linear correlation analysis, however, the partial correlation coefficients of HbA 1C (basal and variations) with Eselectin concentration (basal and variations) fell to non-significant values (r = 0.12 and 0.25, respectively) when LDL lag phase and plasma hydroperoxides were kept constant. The results indicate that the improvement of metabolic control in NIDDM patients is associated with a decrease of E-selectin plasma levels; they also suggest that glycaemic control per se is not directly implicated in determining E-selectin plasma concentration; glycaemic control could affect E-selectin concentration through its effect on oxidative stress. [Diabetologia (1997) 40: 584-589]

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“…It is important to note that glycemic control plays an important role in peroxidation of fatty acids (WieruszWysocka et al, 1995) and the well-controlled diabetic patients (HbA1c<6.5%) demonstrate a lower level of lipid peroxidation markers (Griesmacher et al, 1995;Jain and McVie, 1999;Vantyghem et al, 2000). Since the mean HbA1c in the diabetic children was >8%, therefore this can explain the increase in MDA in this study.…”

Section: Discussionmentioning

confidence: 56%

Elevation of oxidative stress markers in Type 1 diabetic children

Stambouli-Guerriche¹,

Mokhtari-Soulimane²,

Merzouk³

et al. 2015

J. Diabetes Endocrinol.

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Children's diabetes is represented by the Type 1 diabetes mellitus (T1DM). In T1DM, the persistence of hyperglycemia has been reported to cause increased production of oxygen free radicals through glucose autooxidation and nonenzymatic glycation. The aim of this study was to evaluate markers of oxidant/antioxidant status in diabetic children of Western Algeria. This study included 40 children with T1DM with mean age of 7.5 ± 1.7 years and 40 healthy age and sex matched controls. They were subjected to assessment of indicative parameters of lipoperoxidation, protein oxidation, changes in the status of antioxidant defense systems, plasma oxygen radical absorbance capacity (ORAC), glycated hemoglobin (HbA1c), total cholesterol and triglycerides. Malondialdehyde (MDA) and carbonyl proteins levels in plasma were significantly higher (4.03 ± 0.39 versus 2.53 ± 0.4 µmol/L, 5.03 ± 0.57 versus 3 ± 0.38 nmol/mg protein, respectively; P < 0.001) and a significant reduction in plasma total antioxidant capacity and vitamin C was observed in diabetic children than the controls (1.55 ± 0.28 versus 2.5 ± 0.23 AU, 37.58 ± 5.76 versus 48.8 ± 4.47 µmol/L, respectively; P < 0.001). Erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities were significantly higher (520 ± 40.42 versus 392.7 ± 42.66 U/g hemoglobin, 71.08 ± 5.18 versus 56.6 ± 2.84 U/g hemoglobin, respectively; P < 0.001), whereas erythrocyte glutathione reductase (GSH) reduced significantly (34.98 ± 2.34 versus 42.68 ± 3.03 U/g hemoglobin, respectively; P < 0.001) in diabetic children than the control subject. The present finding suggested that young diabetic patients were susceptible to oxidative stress. Appropriate support for enhancing antioxidant supply in these patients may help prevent complications due to oxidative injury.

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Enhanced serum levels of thiobarbituric-acid-reactive substances in diabetes mellitus

Cited by 259 publications

References 20 publications

Relationships between plasma measures of oxidative stress and metabolic control in NIDDM

Relationships between plasma measures of oxidative stress and metabolic control in NIDDM

E-Selectin plasma concentration is influenced by glycaemic control in NIDDM patients: possible role of oxidative stress

Elevation of oxidative stress markers in Type 1 diabetic children

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