Enhanced Sequence-Specific DNA Recognition Using Oligodeoxynucleotide-Benzimidazole Conjugates
Souvik Sur,
Suresh Pujari,
Nihar Ranjan
et al.
Abstract:Synthetic modification of oligodeoxynucleotides (ODNs)
via conjugation
to nucleic acid binding small molecules can improve hybridization
and pharmacokinetic properties. In the present study, five Hoechst
33258 derived benzimidazoles were conjugated to T rich ODNs and their
hybridization effectiveness was tested. Thermal denaturation studies
revealed significant stabilization of complementary duplexes by ODN-benzimidazole
conjugates, with the extent of stabilization being highly dependent
on the length of the l… Show more
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