Enhanced Sensitized NIR Luminescence from Gold Nanoparticles via Energy Transfer from Surface-Bound Fluorophores

Montalti, Marco; Zaccheroni, Nelsi; Prodi, Luca; O'Reilly, Niamh; James, Stuart L.

doi:10.1021/ja068095d

Cited by 72 publications

(52 citation statements)

References 18 publications

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“…New synthetic approaches have yielded highly luminescent gold nanoparticles with emissions ranging from 400 to 1200 nm [129,130]. Nanoparticles with this NIR emission makes them suitable for optical imaging as they are less affected by autofluorescence and provide better contrast of the target tissues.…”

Section: Nanoparticlesmentioning

confidence: 99%

Imaging and drug delivery using theranostic nanoparticles

Janib

Moses

MacKay

2010

Advanced Drug Delivery Reviews

1,088

766

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Nanoparticle technologies are significantly impacting the development of both therapeutic and diagnostic agents. At the intersection between treatment and diagnosis, interest has grown in combining both paradigms into clinically effective formulations. This concept, recently coined as theranostics, is highly relevant to agents that target molecular biomarkers of disease and is expected to contribute to personalized medicine. Here we review state-of-the-art nanoparticles from a therapeutic and a diagnostic perspective and discuss challenges in bringing these fields together. Major classes of nanoparticles include, drug conjugates and complexes, dendrimers, vesicles, micelles, core–shell particles, microbubbles, and carbon nanotubes. Most of these formulations have been described as carriers of either drugs or contrast agents. To observe these formulations and their interactions with disease, a variety of contrast agents have been used, including optically active small molecules, metals and metal oxides, ultrasonic contrast agents, and radionuclides. The opportunity to rapidly assess and adjust treatment to the needs of the individual offers potential advantages that will spur the development of theranostic agents.

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Section: Nanoparticlesmentioning

confidence: 99%

Imaging and drug delivery using theranostic nanoparticles

Janib

Moses

MacKay

2010

Advanced Drug Delivery Reviews

1,088

766

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“…The conjugated molecules adsorbed on the surface of gold nanoparticles through their electron or hole transfer capability further modify the electrochemical properties of gold nanoparticles. [1][2][3][4][5] Gold nanoparticles coated with monolayers bearing fluorescent groups have also been found to be very useful fillers in light emitting and conducting polymers for creating hybrid organic-inorganic materials or nanocomposites with enhanced light emitting and conducting properties. [6] The preparation of gold nanoparticles coated with newly designed and synthesized fluorescent organic compounds thus becomes an important step toward preparations of hybrid gold nanoparticles for the applications mentioned above.…”

Section: Introductionmentioning

confidence: 99%

Identification of thiol from 11-(9-carbazolyl)-1-undecyl disulfide by NMR spectroscopy and single step coating of gold nanoparticles

Jadhav

Maccagno

2014

Journal of Sulfur Chemistry

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Disulfide-functionalized fluorescent derivative of carbozole named 11-(9-carbazolyl)-1-undecyl disulfide (CBZDS) has been synthesized. Proton nuclear magnetic resonance spectroscopy was used to distinguish thiol from its corresponding symmetrical disulfide. Single step synthesis of gold nanoparticles coated with CBZDS was carried out which resulted in stable monolayers of CBZDS on gold nanoparticles.

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“…11 Metal nanoparticles, especially of gold, are also widely studied for FRET-based techniques. [15][16][17][18][19][20][21][22][23][24] A goldnanoparticle-based FRET probe has been developed for ultrasensitive detection of anthrax DNA. 15 In a recent report, a rapid and simple immunoassay protocol for detection of C-reactive protein and osteopontin has been developed by mixing them with gold nanoparticles and employing FRET between them.…”

Section: Introductionmentioning

confidence: 99%

Quantum Clusters of Gold Exhibiting FRET

et al. 2008

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Fluorescence resonance energy transfer between the metal core and the ligand in Au 25 SG 18 (SG-glutathione thiolate) is demonstrated using dansyl chromophores attached to the cluster core through glutathione linkers. The dansyl chromophore functionalization of the cluster has been carried out by two different routes. Efficient energy transfer from the dansyl donor to the Au 25 core is manifested by way of the reduced lifetime of the excited state of the former and drastic quenching of its fluorescence. The donor-acceptor separation observed in the two synthetic routes reflects the asymmetry in the ligand binding on the cluster core, which is in agreement with the recent theoretical and experimental results on the structure of Au 25 .

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Enhanced Sensitized NIR Luminescence from Gold Nanoparticles via Energy Transfer from Surface-Bound Fluorophores

Cited by 72 publications

References 18 publications

Imaging and drug delivery using theranostic nanoparticles

Imaging and drug delivery using theranostic nanoparticles

Identification of thiol from 11-(9-carbazolyl)-1-undecyl disulfide by NMR spectroscopy and single step coating of gold nanoparticles

Quantum Clusters of Gold Exhibiting FRET

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