Enhanced Risk Stratification With Noninvasive Measurement of Coronary Flow Reserve Using Positron Emission Tomography

Integration of Quantitative Positron Emission Tomography Absolute Myocardial Blood Flow Measurements in the Clinical Management of Coronary Artery Disease

“…The relative error will be even larger when rest MBF is measured, which in turn has the potential to have a substantial impact on the MFR ratio, a parameter that has gained considerable attention in relation to CAD prognosis. [43][44][45][46][47][48] Furthermore, the same study that observed an ischemic threshold of 0.91 mL·min , 42 which is within the margin of error observed in the comparative study 41 noted above. Accordingly, given the importance of absolute values of MBF, both rest and stress, and the potential for methodology-based variation in these values, ideally it would be best for individual laboratories to establish their own normal limits for stress and rest MBF, particularly for 82 Rb.…”

Cardiovascular risk assessment with regadenoson SPECT MPI in patients with end-stage renal disease is safe, effective, and well tolerated: Does it matter?

“…While semi-quantitative assessment of SPECT MPI is an extensively validated risk factor in studies of prognostication, studies of quantitative coronary flow reserve assessment with cardiac PET MPI by Murthy, Ziadi, and Taqueti have been shown to reclassify risk in more than one-third of patients and optimize cardiac risk stratification. [16][17][18][19] Semi-quantitative assessment of regional myocardial perfusion with SPECT MPI and quantitative assessment of global myocardial flow reserve with PET MPI using regadenoson vasodilator stress and rapid routine reversal with aminophylline in patients with ESRD may be expected to provide the most effective, safest, and best tolerated means of identifying the lowest risk patients whose best chance of survival with renal transplantation can be optimally identified.…”