Enhanced retinoid response by a combination of the vitamin A ester retinyl propionate with niacinamide and a flavonoid containingCeratonia siliquaextract in retinoid responsivein vitromodels
Abstract:OBJECTIVES: Retinoids have been used for decades as efficacious topical agents to treat photoaged skin. The purpose of our present research is to evaluate whether the activity of the Vitamin A ester retinyl propionate (RP) can be enhanced by niacinamide (Nam) and a flavonoid containing Ceratonia siliqua (CS) fruit extract in retinoid responsive in vitro models. METHODS: RP was tested alone and in combination with Nam and CS in an RARalpha reporter cell line for promoter activation and compared to trans-retino… Show more
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