Enhanced Replication of Newcastle Disease Virus in Cell Culture Co-infected with Certain Other Viruses

NDV-D90 suppresses growth of gastric cancer and cancer-related vascularization

“…NDV is also known as avian paramyxovirus serotype 1, which belongs to a non-segmented, negative-strand RNA virus of the family Paramyxoviridae with a natural avian host range [3]. The genome of NDV is approximately 15 kb in length that encodes 6 structural proteins.…”

“…The genome of NDV is approximately 15 kb in length that encodes 6 structural proteins. Recent advance in application of virulence associated with human pathogens renders animal viruses as a promising therapeutic agent for tumor, since NDV does not have significant adverse effects in humans [3]. Interestingly, the selective targeting and the destruction of replicative tumor cells by NDV seemingly originates from the defective interferon signaling pathways in tumor cells, since interferon regulatory factor genes encode DNA-binding proteins that are involved in the innate immune response to viral infection [15].…”

“…The anti-cancer potential of Newcastle disease viruses (NDV) has been discovered since 1805s [3]. The selective targeting elimination of replicating tumor cells by NDV stem from the presence of defective Interferon signaling pathways in tumor cells, but an effective antiviral response to hamper viral replication in normal cells [3].…”

“…The selective targeting elimination of replicating tumor cells by NDV stem from the presence of defective Interferon signaling pathways in tumor cells, but an effective antiviral response to hamper viral replication in normal cells [3]. Recently, selection, modification and production of oncolytic NDV with minimal damage of the normal adjacent tissues have been achieved [4, 5].…”

Newcastle disease virus enhances the growth-inhibiting and proapoptotic effects of temozolomide on glioblastoma cells in vitro and in vivo

“…Newcastle disease virus (NDV) is a naturally occurring virus that has been evaluated for the treatment of glioma in early-phase studies 1 , 8 . The selective, targeted elimination of tumor cells by NDV based on the presence of defective interferon signaling in tumor tissue shows that this treatment induce an effective antiviral response to hamper viral replication in normal tissue 9 . Some studies have indicated that NDV can increase apoptosis by suppressing AKT signaling 10 , 11 .…”