Enhanced Release of Elastase Is Not Concomitant With Increased Secretion of Granulocyte-Activating Cytokines in Whole Blood From Patients With Sepsis

Ertel, Wolfgang; Jarrar, Doreid; Jochum, Marianne; Thiele, V. F.; Kenney, John S.; Faist, Eugen; Schildberg, F. W.

doi:10.1001/archsurg.1994.01420250102013

Cited by 23 publications

(6 citation statements)

References 48 publications

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“…The decrease of leukocytes and thrombocytes that was observed after the injection of LPS (80 g/animal) has been described in previous studies (26). This reflects the role of TNF-␣ as a primary inflammatory cytokine (27), which induces the expression of other cytokines (28). This reflects the role of TNF-␣ as a primary inflammatory cytokine (27), which induces the expression of other cytokines (28).…”

Section: Discussionsupporting

confidence: 72%

Pathogenic role of interleukin-6 in the development of sepsis. Part I: Study in a standardized contact burn murine model

Pallua

Heimburg

2003

Critical Care Medicine

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Section: Discussionsupporting

confidence: 72%

Pathogenic role of interleukin-6 in the development of sepsis. Part I: Study in a standardized contact burn murine model

Pallua

Heimburg

2003

Critical Care Medicine

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“…Previous reports have described increased plasma concentrations of molecules liberated by neutrophils (31-34). Plasma HNP1-3 are elevated in patients with sepsis, non-bacterial infection and tuberculosis and plasma levels correlate weakly with peripheral blood neutrophil counts (21).…”

Section: Discussionmentioning

confidence: 98%

Increased plasma arginase activity in human sepsis: association with increased circulating neutrophils

Darcy

Woodberry

Davis³

et al. 2014

Clinical Chemistry and Laboratory Medicine

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Background The pathophysiology of sepsis is incompletely understood. Impaired bioavailability of L-arginine, the substrate for NO synthesis, is linked to sepsis severity, and plasma arginase has been linked to hypoargininemia in other disease states. Circulating neutrophils are increased in sepsis and constitutively express arginase. We investigated whether plasma arginase activity is increased in human sepsis and whether this is associated with neutrophil numbers and activation. Methods We used HPLC and a radiometric assay to evaluate plasma amino acid concentrations and plasma arginase activity. The relationships between plasma arginase activity, neutrophil count, neutrophil activity and plasma L-arginine and arginine metabolites were evaluated in 44 sepsis patients and 25 controls. Results Plasma arginase activity was increased in sepsis patients, correlated with neutrophil count (r=0.44; p=0.003), but was independent of sepsis severity (SOFA or APACHE II score). Plasma HNP1-3 correlated with neutrophil count (r=0.31; p=0.04), was elevated in shock (median 180 ng/mL versus 83 ng/mL sepsis without shock, p=0.0006) and correlated with SOFA score. Sepsis patients with high neutrophil counts had significantly higher plasma HNP1-3 and arginase activity and lower plasma L-arginine concentrations than those with lower neutrophil counts and controls. Conclusions Plasma arginase activity, potentially derived in part from neutrophil activation, is elevated in sepsis, and may contribute to impaired bioavailability of L-arginine in sepsis.

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“…The boosted enzymatic cleavage probably results from an increase of FETUA cleaving enzyme concentration and activity under pathological conditions. For instance, elastase release by human granulocytes increases up to 188% during sepsis compared to healthy control (Ertel et al, 1994). Chymotrypsin and elastase are moreover massively transferred into the blood stream during acute pancreatitis (Nobar et al, 2004).…”

Section: Modelmentioning

confidence: 99%

Accelerated Evolution of Fetuin-A (FETUA, also AHSG) is Driven by Positive Darwinian Selection, not GC-Biased Gene Conversion

Döring

Zechner

Roos

et al. 2010

Gene

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Enhanced Release of Elastase Is Not Concomitant With Increased Secretion of Granulocyte-Activating Cytokines in Whole Blood From Patients With Sepsis

Cited by 23 publications

References 48 publications

Pathogenic role of interleukin-6 in the development of sepsis. Part I: Study in a standardized contact burn murine model

Pathogenic role of interleukin-6 in the development of sepsis. Part I: Study in a standardized contact burn murine model

Increased plasma arginase activity in human sepsis: association with increased circulating neutrophils

Accelerated Evolution of Fetuin-A (FETUA, also AHSG) is Driven by Positive Darwinian Selection, not GC-Biased Gene Conversion

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