Enhanced reactivity and enantioselectivity in catalytic glyoxylate-ene reactions using chiral bis(oxazoline)–copper complex in an ionic liquid

“Green” Pericyclic Reactions Assisted by Ionic Liquids

“…Reactions between olefins and ethyl glyoxylate in [BMIM]SbF 6 at ambient temperature provided remarkably enhanced reactivity and stereoselectivity, which greatly exceed those of the corresponding reactions in dichloromethane. Furthermore, the metal-ligand complex was readily recycled up to eight times, while exhibiting no significant decrease in reaction efficiency (Figure 23) [61]. Very recently, the synthesis of ILs using the ene pericyclic reaction was also described.…”

Room Temperature Ionic Liquids in Asymmetric Hetero-Ene Type Reactions: Improving Organocatalyst Performance at Lower Temperatures

“…Reactions performed at lower temperatures required long times to achieve just poor to moderate conversions [ 29 ]. Considering that RTILs can be efficiently applied to related carbonyl-ene metal-catalyzed processes [ 35 , 36 ], the organocatalyzed hetero-carbonyl-ene reaction of aliphatic α-keto esters was chosen as a suitable platform to explore the effect of a set of RTILs as cosolvents or additives in the catalyst performance.…”

Asymmetric cyclopropanation in ionic liquids promoted by dicopper complexes of ditopic ligands

“…In most cases, the catalytic complex remains dissolved in the IL, whereas the reaction products are removed from this phase by extraction with a suitable solvent. Some examples of application of this strategy using chiral Box-copper complexes as catalysts in Diels-Alder, 8 hetero-Diels-Alder 9 or glyoxylate-ene reactions 10 have been published by Kim and co-workers.…”