Enhanced RAGE-mediated NFκB stimulation in inflamed hemodialysis patients

Rodríguez-Ayala, Ernesto; Anderstam, Björn; Suliman, Mohammed E.; Seeberger, Astrid; Heimbürger, Olof; Lindholm, Bengt; Stenvinkel, Peter

doi:10.1016/j.atherosclerosis.2004.12.007

Cited by 63 publications

(41 citation statements)

References 38 publications

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“…In tubular cells, AGE products activate NF-B via the RAGE in tubular cells (15,21,26). In the amphibian kidney, NF-B expression was upregulated when the tubules were exposed to either carbamylated or glycated albumin.…”

Section: Discussionmentioning

confidence: 99%

Glycated and carbamylated albumin are more “nephrotoxic” than unmodified albumin in the amphibian kidney

Groß

Piecha

Bierhaus

et al. 2011

American Journal of Physiology-Renal Physiology

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Section: Discussionmentioning

confidence: 99%

Glycated and carbamylated albumin are more “nephrotoxic” than unmodified albumin in the amphibian kidney

Groß

Piecha

Bierhaus

et al. 2011

American Journal of Physiology-Renal Physiology

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“…150 Endothelial dysfunction in CKD, which associates with elevated serum levels of AGE, may be due to AGE-induced suppression of endothelial NOS. 151 RAGE is proinflammatory in hemodialysis patients 152 ; sRAGE and endogenous secretory RAGE levels inversely correlate with renal function and inflammatory state in hemodialysis patients. 153,154 Elevated TLR2 expression in patients with CKD and in mice with obstructive nephropathy associates with inflammation and increased expression of biglycan and HMGB1, but TLR2 may not be necessary for chronic kidney injury.…”

Section: Nondiabetic Chronic Kidney Diseasementioning

confidence: 96%

Dangers Within

Rosin¹,

Okusa²

2011

Journal of the American Society of Nephrology

243

185

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“…Enhanced activation of NF-nB, reported for patients with type I and II diabetes, diabetic nephropathy, and on maintenance hemodialysis was at least in part attributed to oxidative stress and inflammation activated by the receptor for advanced glycation end products, followed by induction of intracellular mitogen-activated protein kinase activity (52,53). A down-regulation, but not complete inhibition, of NF-nB DNA binding activity was obtained by the antioxidant a-lipoic acid in patients with diabetic nephropathy (52).…”

Section: Cancer Epidemiology Biomarkers and Prevention Cancer Epidemiomentioning

confidence: 99%

Anthocyanin/Polyphenolic–Rich Fruit Juice Reduces Oxidative Cell Damage in an Intervention Study with Patients on Hemodialysis

Spormann¹,

Albert

Rath

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Hemodialysis patients face an elevated risk of cancer, arteriosclerosis, and other diseases, ascribed in part to increased oxidative stress. Red fruit juice with high anthocyanin/polyphenol content had been shown to reduce oxidative damage in healthy probands. To test its preventive potential in hemodialysis patients, 21 subjects in a pilot intervention study consumed 200 mL/day of red fruit juice (3-week run-in; 4-week juice uptake; 3-week wash-out). Weekly blood sampling was done to monitor DNA damage (comet assay F formamidopyrimidine-DNA glycosylase enzyme), glutathione, malondialdehyde, protein carbonyls, trolox equivalent antioxidant capacity, triglycerides, and DNA binding capacity of the transcription factor nuclear factor-KB. Results show a significant decrease of DNA oxidation damage (P < 0.0001), protein and lipid peroxidation (P < 0.0001 and P < 0.001, respectively), and nuclear factor-KB binding activity (P < 0.01), and an increase of glutathione level and status (both P < 0.0001) during juice uptake. We attribute this reduction in oxidative (cell) damage in hemodialysis patients to the especially high anthocyanin/polyphenol content of the juice. This provides promising perspectives into the prevention of chronic diseases such as cancer and cardiovascular disease in population subgroups exposed to enhanced oxidative stress like hemodialysis patients. (Cancer Epidemiol Biomarkers Prev 2008; 17(12):3372 -80)

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Enhanced RAGE-mediated NFκB stimulation in inflamed hemodialysis patients

Cited by 63 publications

References 38 publications

Glycated and carbamylated albumin are more “nephrotoxic” than unmodified albumin in the amphibian kidney

Glycated and carbamylated albumin are more “nephrotoxic” than unmodified albumin in the amphibian kidney

Dangers Within

Anthocyanin/Polyphenolic–Rich Fruit Juice Reduces Oxidative Cell Damage in an Intervention Study with Patients on Hemodialysis

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