2015
DOI: 10.1093/pm/pnv035
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Enhanced RAGE Expression in the Dorsal Root Ganglion May Contribute to Neuropathic Pain Induced by Spinal Nerve Ligation in Rats

Abstract: RAGE signaling may contribute to the pain hypersensitivity observed in the rat SNL model of NP. Although the precise mechanism remains to be established, NF-κB, TNF-α, and IL-1β likely play a role, together with the activation of SGCs.

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Cited by 13 publications
(14 citation statements)
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“…Increased RAGE expression has been previously reported in the DRGs of long-term diabetic rats [ 37 ], and in the development of neuropathic pain after nerve injury [ 38 ]. However, whether RAGE expression is linked to the electrophysiological abnormalities we observed with CAP-evoked responses under high glucose in this study, remains to be explored.…”
Section: Resultsmentioning
confidence: 99%
“…Increased RAGE expression has been previously reported in the DRGs of long-term diabetic rats [ 37 ], and in the development of neuropathic pain after nerve injury [ 38 ]. However, whether RAGE expression is linked to the electrophysiological abnormalities we observed with CAP-evoked responses under high glucose in this study, remains to be explored.…”
Section: Resultsmentioning
confidence: 99%
“…Systemic pretreatment with either a TLR4 (TAK-242) or a RAGE (FPS-ZM1) antagonist blocked abdominal mechanical hypersensitivity induced by disulfide HMGB1. Since both of these antagonists cross the blood-brain barrier [12, 30], the effect may be due to antagonism of central TLR4 or RAGE receptors and these receptors mediate pain in other models [24, 25]. We applied antagonists intravesically to determine whether and which of these receptors mediated the effect of disulfide HMGB1 at the organ level.…”
Section: Discussionmentioning
confidence: 99%
“…They were anesthetized with an intraperitoneal injection of 10% chloral hydrate (300 mg/kg). A PE-10 polyethylene catheter was implanted between the L 5 and L 6 vertebrae to reach the subarachnoid space of the spinal cord as described in a previous study [22]. The outer part of the catheter was plugged and fixed onto the skin upon wound closure.…”
Section: Methodsmentioning
confidence: 99%