Enhanced Proteolytic Activity and Fc Receptor Expression in Human Epithelial Cells Following Exposure to Sulfur Mustard

Biochemical Alterations in Rat Lung Lavage Fluid Following Acute Sulfur Mustard Inhalation: Ii. Increases in Proteolytic Activity

“…These include adhesion molecules, cytokines, and complement components, and HEK are known to express the Fc receptors (FcR) CD16 and CD32 (Cowa n & Broomfield, 1993;Hunyadi et al, 1992;Cowan et al, 1996). Assay with anti-FcR fluorescent antibodies demonstrated that exposure of HEK to HD increased the CD32 FcR in a time-and concentration-dependent manner that was consistent with the appearance of HD-increased proteolysis and HD toxicity (Cowan et al, 1996 ). Therefore, proteolysis or protease receptor interactions may contribute to the metabolic disruption and/or inflammation associated with HD exposure.…”