Enhanced production possibility of the therapeutic radionuclides 64Cu, 67Cu and 89Sr via (n,p) reactions induced by fast spectral neutrons

Spahn, Ingo; Coenen, Heinz H.; Qaim, S.M.

doi:10.1524/ract.92.3.183.30489

Cited by 47 publications

(19 citation statements)

References 13 publications

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“…The good agreement testifies the validity of both techniques. In the case of the 89 Y(n,p) 89 Sr reaction, the neutron spectrum averaged cross section could be determined as 0.91 ± 0.14 mb [8]. It is about 3 times higher than that with fission neutrons, suggesting that this therapeutic radionuclide could be conveniently produced using ADS type neutron fields.…”

Section: Results and Conclusionmentioning

confidence: 94%

Nuclear Reaction Cross-Section Measurements via Characterization of Soft Radiation Emitting Products

Kettern¹,

Spahn²,

Spellerberg³

et al. 2005

AIP Conference Proceedings

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Nuclear reaction cross-section measurements via the activation technique are generally made using highresolution γ-ray spectrometry. However, in cases where the radioactive product decays exclusively by EC (without emitting a γ-ray) resort has to be made to the rather subtle technique of x-ray spectrometry. Similarly for characterisation of pure β − emitters, gas-flow proportional or liquid-scintillation counting is applied. In both cases the use of radiochemical methods is most essential. We studied the nat Ti(p,xn) 49 V and 85 Rb(p,4n) 82 Sr reactions via x-ray spectrometry. In each case a clean radiochemical separation was performed and a thin source was prepared. The radioactivity of 49 V was determined using the soft 4.5-keV k α x-rays and that of 82 Sr via the 13.4-keV k α x-rays. In another study, the reactions nat Ti(p,x) 45 Ca, 89 Y(n,p) 89 Sr, and nat Pb(p,x) 204 Tl were investigated. All the products are pure β − emitters and therefore clean radiochemical separations were mandatory. The radioactivity of each of the three products was determined via low-level anticoincidence β − counting. Furthermore, in the case of 45 Ca, liquid-scintillation counting was also used. The results obtained using different techniques are compared.

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Section: Results and Conclusionmentioning

confidence: 94%

Nuclear Reaction Cross-Section Measurements via Characterization of Soft Radiation Emitting Products

Kettern¹,

Spahn²,

Spellerberg³

et al. 2005

AIP Conference Proceedings

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“…Some new cross section measurements relevant to its production in nocarrier-added form [18] have strengthened the database. [19,20] using a 14 MeV d(Be) neutron source. A discussion of the results led to the conclusion that higher yields of those radionuclides would be obtained using a spallation neutron source than the present day fission reactors.…”

Section: Optimisation Studies Relevant To Production Routes Of Some Smentioning

confidence: 99%

New trends in nuclear data research for medical radionuclide production

Qaim

2013

Radiochimca Acta

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Medical radionuclide / Optimisation of production route / Nuclear reaction cross section / Standardisation of data / Alternative routes for production of 99m Tc and 68 Ga / Non-standard positron emitter / Novel therapeutic radionuclide Summary. Nuclear reaction cross section data are of great significance in optimisation of production routes of radionuclides. This article deals with some newer aspects of data research related to production of both standard and novel radionuclides. The recent work to standardise the known data is discussed and new measurements with regard to further optimisation of production routes of some commonly used radionuclides are mentioned. Attempts to increase the specific activity of some reactor-produced radionuclides through the use of charged-particle induced reactions are outlined. The jeopardy in the supply of 99m Tc via a fission-produced 99 Mo/ 99m Tc generator is considered and its possible direct production at a cyclotron is briefly discussed. Regarding the novel radionuclides, development work is presently focussed on non-standard positron emitters for diagnosis and on low-range highly ionising radiation emitters for internal radiotherapy. Recent nuclear reaction cross section measurements related to the production of the two types of radionuclides are briefly reviewed and some anticipated trends in nuclear data research are considered.

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“…For studying the 153 Eu(n,p) 153 Sm reaction the samples were irradiated with fast neutrons produced via the breakup of 14 MeV deuterons on a thick Be-target [6,7] in the 0 • direction relative to the deuteron beam. The distance between the sample and the neutron source was 1 cm and the deuteron beam current was kept constant at 5 µA.…”

Section: Irradiationsmentioning

confidence: 99%

New nuclear data for production of ⁷³As, ⁸⁸Y and ¹⁵³Sm: important radionuclides for environmental and medical applications

Spahn

Steyn

Kandil

et al. 2007

Nd2007

Self Cite

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Abstract. The radionuclides 73 As, 88 Y and 153 Sm are of considerable significance in environmental and biological research as well as in internal radiotherapy. Cross section measurements related to the n.c.a. production of these radionuclides were carried out for the nuclear reactions nat Ge(p,xn) 73 As, nat Rb(α,xn) 88 Y and 150 Nd(α,n) 153 Sm, using protons and alpha particles of energies up to 100 MeV and 26.5 MeV, respectively. The excitation function of the 150 Nd(α,n) 153 Sm reaction has been measured for the first time. The existing nuclear database for the other two nuclides could be expanded and strengthened. In the case of 153 Sm additionally the 153 Eu(n,p) 153 Sm reaction cross section was measured averaged over a 14 MeV d(Be) neutron spectrum. The calculation of thick target yields was done and the production possibilities of the three radionuclides were evaluated.

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Enhanced production possibility of the therapeutic radionuclides ⁶⁴Cu, ⁶⁷Cu and ⁸⁹Sr via (n,p) reactions induced by fast spectral neutrons

Cited by 47 publications

References 13 publications

Nuclear Reaction Cross-Section Measurements via Characterization of Soft Radiation Emitting Products

Nuclear Reaction Cross-Section Measurements via Characterization of Soft Radiation Emitting Products

New trends in nuclear data research for medical radionuclide production

New nuclear data for production of ⁷³As, ⁸⁸Y and ¹⁵³Sm: important radionuclides for environmental and medical applications

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Enhanced production possibility of the therapeutic radionuclides 64Cu, 67Cu and 89Sr via (n,p) reactions induced by fast spectral neutrons

Cited by 47 publications

References 13 publications

Nuclear Reaction Cross-Section Measurements via Characterization of Soft Radiation Emitting Products

Nuclear Reaction Cross-Section Measurements via Characterization of Soft Radiation Emitting Products

New trends in nuclear data research for medical radionuclide production

New nuclear data for production of 73As, 88Y and 153Sm: important radionuclides for environmental and medical applications

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Enhanced production possibility of the therapeutic radionuclides ⁶⁴Cu, ⁶⁷Cu and ⁸⁹Sr via (n,p) reactions induced by fast spectral neutrons

New nuclear data for production of ⁷³As, ⁸⁸Y and ¹⁵³Sm: important radionuclides for environmental and medical applications