Enhanced Pro-apoptotic Effects of Fe(II)-Modified IVIG on Human Neutrophils

Graeter, Stefanie; Schneider, Christoph; Verschoor, Daniëlle; Däniken, Sandro von; Seibold, Frank; Yawalkar, Nikhil; Villiger, Peter M.; Dimitrov, Jordan D.; Smith, David F.; Cummings, Richard D.; Simon, Hans‐Uwe; Vassilev, Tchavdar; Gunten, Stephan von

doi:10.3389/fimmu.2020.00973

Cited by 7 publications

(11 citation statements)

References 45 publications

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“…IVIG preparations are composed of polyclonal plasma-derived IgG from thousands of donors, which secrete a large number of antibodies that are specific and conducive to play an anti-inflammatory role [ 19 – 21 ]. In KD, IVIG can reverse the abnormally delayed apoptosis of circulating neutrophils via lowering the blood neutrophil count [ 22 ]. At present, IVIG has been widely used in childhood diseases such as Guillain–Barre syndrome, Henoch–Schönlein purpura, and multiple-system inflammatory syndrome, exerting positive effects on relieving inflammation and clinical symptoms to varying degrees [ 23 – 25 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Glucocorticoid plus Intravenous Immunoglobulin in Children with Immunoglobulin-Insensitive Kawasaki Disease

Zhang

Fan

2022

Journal of Healthcare Engineering

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This study mainly analyzes the clinical effect of glucocorticoid (GC) plus intravenous immunoglobulin (IVIG) in treating children with immunoglobulin (Ig)-insensitive Kawasaki disease (KD). From September 2013 to November 2021, 86 Ig-insensitive KD children were selected, including 46 children (observation group, Obs) treated with GC plus IVIG, and 40 children (control group, Con) treated with IVIG. The symptom (fever and fever) resolution time, inflammatory factors (C-reactive protein, CRP; procalcitonin, PCT; interleukin-6, IL-6), immune indicators (CD3+, CD4+, CD8+ T lymphocytes CD3+, CD4+, and CD4+/CD8+), and incidence of adverse reactions were compared between the groups. The results identified shorter fever and rash resolution time in Obs compared with Con. The posttreatment CRP, PCT, IL-6, and CD8+ and the incidence of adverse events reduced notably in Obs and were lower than Con, while CD3+, CD4+, and CD4+/CD8+ elevated statistically and were higher than that of Con. Our results indicate that GC plus IVIG can significantly promote symptom resolution, alleviate inflammatory response, and improve immune function in children with Ig-insensitivity KD, with favorable safety and clinical promotion value.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Glucocorticoid plus Intravenous Immunoglobulin in Children with Immunoglobulin-Insensitive Kawasaki Disease

Zhang

Fan

2022

Journal of Healthcare Engineering

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“…As an immunoglobulin, gamma globulin is mostly used for the treatment of infectious diseases clinically [ 8 ]. It can block the Fc receptors on the surface of platelets, mononuclear phagocytes, and vascular endothelial cells and reduce the vascular immune inflammatory response [ 9 , 10 ]. Immunoglobulin contains various antibodies required by the body to enhance the immune function and prevent infection.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound Comparative Analysis of Coronary Arteries before and after Immune Blocking Therapy with Gamma Globulin in Children with Kawasaki Disease

Chen

Xiang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the ultrasound characteristics and clinical efficacy of coronary arteries before and after immune blocking therapy with gamma globulin in children with Kawasaki disease. Methods. A total of 64 children with Kawasaki disease who were treated in our hospital from January 2018 to October 2021 were selected. All the children were given immune blocking therapy with gamma globulin on the basis of conventional treatment. The disappearance time of related symptoms and signs (fever, mucosal congestion, cervical lymphadenopathy, and swelling of the hands and feet) in children were counted. The white blood cell count (WBC), platelet count (PLT), C-reactive protein (CRP), and procalcitonin (PCT) levels of the children before and after treatment were compared, and the characteristics of coronary echocardiography before and after treatment were observed for analysis and discussion, to carefully observe whether the coronary artery involvement of the children was improved. Results. The inner diameter of the left and right coronary arteries significantly decreased ( P < 0.05 ), and the levels of leukocytes, platelets, CRP, erythrocyte sedimentation rate, vascular endothelial growth factor (VEGF), and endostatin were significantly decreased compared with those before treatment, with a statistical difference ( P < 0.05 ). Conclusion. The effect of gamma globulin in the treatment of Kawasaki disease is remarkable, which can improve the blood indexes, VEGF, and endostatin levels in children, significantly reduce coronary dilatation, and reduce the incidence of coronary artery disease. Echocardiography is of high value in the examination of children with Kawasaki disease, which can accurately detect the size, location, and inner diameter of coronary artery lesions, and can effectively evaluate the treatment effect on children.

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“…in pathogen neutralization) (reviewed in ( 6 )). Furthermore, the human repertoire of IgG antibodies contains functional antibodies specific for immunoregulatory receptors such as Fas ( 8 – 10 ) or Siglecs ( 5 , 11 , 12 ), that exhibit the capacity to regulate the survival of immune cells ( 13 ). Many noncanonical functions of antibodies are exclusively exerted by the variable region of the antibody ( 6 ), and their occurrence may thus differ among individuals depending on their private antibody repertoire.…”

Section: Canonical and Noncanonical Functions Of Antibodiesmentioning

confidence: 99%

Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs

et al. 2023

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Significant progress has been made in the elucidation of human antibody repertoires. Furthermore, non-canonical functions of antibodies have been identified that reach beyond classical functions linked to protection from pathogens. Polyclonal immunoglobulin preparations such as IVIG and SCIG represent the IgG repertoire of the donor population and will likely remain the cornerstone of antibody replacement therapy in immunodeficiencies. However, novel evidence suggests that pooled IgA might promote orthobiotic microbial colonization in gut dysbiosis linked to mucosal IgA immunodeficiency. Plasma-derived polyclonal IgG and IgA exhibit immunoregulatory effects by a diversity of different mechanisms, which have inspired the development of novel drugs. Here we highlight recent insights into IgG and IgA repertoires and discuss potential implications for polyclonal immunoglobulin therapy and inspired drugs.

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Enhanced Pro-apoptotic Effects of Fe(II)-Modified IVIG on Human Neutrophils

Cited by 7 publications

References 45 publications

Efficacy of Glucocorticoid plus Intravenous Immunoglobulin in Children with Immunoglobulin-Insensitive Kawasaki Disease

Efficacy of Glucocorticoid plus Intravenous Immunoglobulin in Children with Immunoglobulin-Insensitive Kawasaki Disease

Ultrasound Comparative Analysis of Coronary Arteries before and after Immune Blocking Therapy with Gamma Globulin in Children with Kawasaki Disease

Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs

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