Enhanced Preservation of the Ischæmic Kidney With Inosine

Observations on the energy and redox state and protein synthetic rate in animal and human placentas

“…No protection was achieved using inosine, which is known to be beneficial in the ischemic kidney [9]. The initial energy charge in both animal and human placentas was similar to that observed by PENFOLD et al [22] and did not change markedly during ischemia as the latter observed.…”

Remote Reperfusion Lung Injury is Associated With AMP Deaminase 3 Activation and Attenuated by Inosine Monophosphate

“…The administration of IMP prior to ischemia maintains a high concentration of IMP during ischemia. 25 In the present study, constant administration of IMP also resulted in a significant elevation of plasma IMP concentration (before IMP administration: 0.035 mmol/L, after IMP administration: 0.2 mmol/L, p< 0.05) and ameliorated neutrophil infiltration and reduced MPO activity and TNF-production in the lungs, with amelioration of decreased SpO2. We acknowledge the limitations of the present study because we did not evaluate the effects of AMPD inhibition and endogenous IMP production on the remote lung injury.…”

Superficial Nephron Obstruction and Medullary Congestion after Ischemic Injury: Effect of Protective Treatments

“…Inosine given intravenously in a pilot study showed no protection in our model as in other studies [26] so we then applied it directly into the renal artery immediately before arterial occlusion as suggested elsewhere [11,12], and found significant functional protection. As judged by light microscopy, the degree of structural protection was the greatest in the inosine-treated group of rats.…”