Enhanced potato tuber penetration of carboxin via ultradeformable liposomes

Васильева, Л. А.; Gaynanova, Gulnara A.; Nizameev, Irek R.; Petrova, Anna A.; Kadirov, Marsil K.; Gorshkova, Tatyana A.; Zakharova, L. Ya.

doi:10.1016/j.fbio.2022.102003

Cited by 2 publications

(2 citation statements)

References 78 publications

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“…Phosphatidylcholine and Tween 20 are classic transfersomal ingredients [ 26 , 27 , 28 , 29 , 30 ]. In addition to Tween 20, other non-ionic surfactants can also be included in the transfersome composition: sodium deoxycholate, sorbitan monooleate (Span 80), polysorbate 80 (Tween 80) [ 31 , 32 , 33 ], etc.…”

Section: Discussionmentioning

confidence: 99%

“…Due to transfersome extrusion through a polycarbonate membrane with a pore size of 100 nm, the hydrodynamic diameter of the systems was maintained at 100–120 nm ( Table 1 ). It should be noted that the addition of a non-ionic surfactant to liposomes led to a decrease in the transfersome size, probably due to the formation of mixed micelles, which leads to a decrease in phospholipid monomers and compaction of aggregates [ 30 , 35 , 36 ]. According to the results, the size of the vesicles slightly increased with increasing concentration of C n PB compared with classical transfersomes, and approached the size of PC liposomes.…”

Section: Discussionmentioning

confidence: 99%

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Transdermal Delivery of 2-PAM as a Tool to Increase the Effectiveness of Traditional Treatment of Organophosphate Poisoning

Васильева

Gaynanova

Zueva

et al. 2022

IJMS

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For the first time, the efficacy of post-exposure treatment of organophosphate (OP) poisoning was increased by transdermal delivery of acetylcholinesterase (AChE) reactivator pyridine-2-aldoxime methochloride (2-PAM) as a preventive countermeasure. By selecting the optimal ratio of components, classical transfersomes (based on soybean phosphatidylcholine and Tween 20) and modified transfersomes (based on soybean phosphatidylcholine, Tween 20 and pyrrolidinium cationic surfactants with different hydrocarbon tail lengths) were obtained for 2-PAM encapsulation. Transfersomes modified with tetradecylpyrrolidinium bromide showed the best results in encapsulation efficiency and sustained release of 2-PAM from vesicles. Using Franz cells, it was found that the incorporation of surfactants into PC liposomes results in a more prolonged release of 2-PAM through the rat skin. Transfersomes containing 2-PAM, after exhaustive physical and chemical characterization, were embedded in a gel based on Carbopol® 940. A significantly high degree of erythrocyte AChE reactivation (23 ± 7%) was shown for 2-PAM in unmodified transfersomes in vivo. Preliminary transdermal administration of 2-PAM 24 h before emergency post-exposure treatment of OP poisoning leads to an increase in the survival rate of rats from 55% to 90%.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Transdermal Delivery of 2-PAM as a Tool to Increase the Effectiveness of Traditional Treatment of Organophosphate Poisoning

Васильева

Gaynanova

Zueva

et al. 2022

IJMS

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Supramolecular Strategy for the Design of Nanocarriers for Drugs and Natural Bioactives: Current State of the Art (A Review)

Zakharova,

Maganova,

Sinyashin

et al. 2023

Russ J Gen Chem

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The review focuses on the lipid based nanocarriers, with special attention paid to natural bioactive payloads. First, micelles and microemulsions are considered as very attractive colloidal nanocontainers that allow for marked improving the solubility of hydrophobic bioactives. Further, liposomal vehicles are reviewed, with both advantages and limitations discussed. Literature assay covers up-to-date information of about last three to five years, although brief background is given on the pioneer works addressing the liposomes and their evolution from bench to bedside. Final part of the review is devoted to the modern modifications of vesicular nanocarriers which can be adapted to specific administration way due to improved targeting properties, permeability, mucoadhesiveness and possibility to cross biological barriers. Therein, such kinds of nanocarriers as transfersomes, niosomes, ethosomes, chitosomes are evaluated; and separate sections focus on the natural based formulations, i.e., phytosomes and invasomes.

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Enhanced potato tuber penetration of carboxin via ultradeformable liposomes

Cited by 2 publications

References 78 publications

Transdermal Delivery of 2-PAM as a Tool to Increase the Effectiveness of Traditional Treatment of Organophosphate Poisoning

Transdermal Delivery of 2-PAM as a Tool to Increase the Effectiveness of Traditional Treatment of Organophosphate Poisoning

Supramolecular Strategy for the Design of Nanocarriers for Drugs and Natural Bioactives: Current State of the Art (A Review)

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