Enhanced piezoelectric response of hybrid biodegradable 3D poly(3-hydroxybutyrate) scaffolds coated with hydrothermally deposited ZnO for biomedical applications

Zviagin, Andrei; Chernozem, Roman V.; Surmeneva, Maria A.; Pyeon, Myeongwhun; Mathur, Sanjay; Ludwig, Tim; Tutacz, Peter; Ivanov, Yurii; Surmenev, Roman A.

doi:10.1016/j.eurpolymj.2019.05.016

Cited by 48 publications

(23 citation statements)

References 40 publications

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“…43−48 ImClO 4 also shows a favorable d 33 of 46 pC N −1 , which is superior to those of PVDF with a d 33 of ∼30 pC N 1− , 49 let alone those of natural and artificial biodegradable piezoelectric materials such as chitins, keratins, PLLA, and PHB. 13,25,26,50 The BC hydrogels were prepared by incubating the Gluconacetobacter xylinus culture at 30 °C for 7 days. After treatment with 0.1 M sodium hydroxide solution and being thoroughly washed several times with distilled water, pure BC hydrogels were obtained.…”

Section: Resultsmentioning

confidence: 99%

“…, three-dimensional gear-like or hierarchical porous micro- or nanostructures for high performance. − Piezoelectricity, polarization charges generated by mechanical-stimuli-induced distortion in polarized materials, is another competitive mechanism for self-powered mechanical sensors . Also zeroing in on the e-waste issue, the piezoelectric effect has been explored in natural biological materials such as chitins, onionskin, and fish scale, and artificial biodegradable materials including poly( l -lactic acid) (PLLA), poly(3-hydroxybutyrate) (PHB), and poly(ε-caprolactone) (PCL). − Nevertheless, the piezoelectric effect of these materials is far inferior to that of typical ferroelectric ceramics and polymers, rendering the sensors insensitive to mechanical stimuli.…”

Section: Introductionmentioning

confidence: 99%

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A Biodegradable and Recyclable Piezoelectric Sensor Based on a Molecular Ferroelectric Embedded in a Bacterial Cellulose Hydrogel

et al. 2022

ACS Nano

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Currently, various electronic devices make our life more and more safe, healthy, and comfortable, but at the same time, they produce a large amount of nondegradable and nonrecyclable electronic waste that threatens our environment. In this work, we explore an environmentally friendly and flexible mechanical sensor that is biodegradable and recyclable. The sensor consists of a bacterial cellulose (BC) hydrogel as the matrix and imidazolium perchlorate (ImClO 4 ) molecular ferroelectric as the functional element, the hybrid of which possesses a high sensitivity of 4 mV kPa −1 and a wide operational range from 0.2 to 31.25 kPa, outperforming those of most devices based on conventional functional biomaterials. Moreover, the BC hydrogel can be fully degraded into glucose and oligosaccharides, while ImClO 4 can be recyclable and reused for the same devices, leaving no environmentally hazardous electronic waste.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Biodegradable and Recyclable Piezoelectric Sensor Based on a Molecular Ferroelectric Embedded in a Bacterial Cellulose Hydrogel

et al. 2022

ACS Nano

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“…Despite plasma treatment easily realizing the hydrophilic and rough surface which benefits cell adhesion and spreading [80], it is not the most ideal strategy for durable surface treatment due to transient effect and tedious device. Deposition of hydrophilic compounds is another common strategy for achieving the hydrophilic surface [170,171]. For instance, the PHB scaffold could be directly immersed into the hydrophilic chemical diazonium of ADT-(COOH) 2 for surface hydrophilic treatment [172].…”

Section: Current Challenges and Solutionsmentioning

confidence: 99%

Electrical Stimulation Enabled via Electrospun Piezoelectric Polymeric Nanofibers for Tissue Regeneration

2022

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Electrical stimulation has demonstrated great effectiveness in the modulation of cell fate in vitro and regeneration therapy in vivo. Conventionally, the employment of electrical signal comes with the electrodes, battery, and connectors in an invasive fashion. This tedious procedure and possible infection hinder the translation of electrical stimulation technologies in regenerative therapy. Given electromechanical coupling and flexibility, piezoelectric polymers can overcome these limitations as they can serve as a self-powered stimulator via scavenging mechanical force from the organism and external stimuli wirelessly. Wireless electrical cue mediated by electrospun piezoelectric polymeric nanofibers constitutes a promising paradigm allowing the generation of localized electrical stimulation both in a noninvasive manner and at cell level. Recently, numerous studies based on electrospun piezoelectric nanofibers have been carried out in electrically regenerative therapy. In this review, brief introduction of piezoelectric polymer and electrospinning technology is elucidated first. Afterward, we highlight the activating strategies (e.g., cell traction, physiological activity, and ultrasound) of piezoelectric stimulation and the interaction of piezoelectric cue with nonelectrically/electrically excitable cells in regeneration medicine. Then, quantitative comparison of the electrical stimulation effects using various activating strategies on specific cell behavior and various cell types is outlined. Followingly, this review explores the present challenges in electrospun nanofiber-based piezoelectric stimulation for regeneration therapy and summarizes the methodologies which may be contributed to future efforts in this field for the reality of this technology in the clinical scene. In the end, a summary of this review and future perspectives toward electrospun nanofiber-based piezoelectric stimulation in tissue regeneration are elucidated.

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“…The ZnO coating increased the piezoelectric charge coefficient by more than a factor of 4, as compared to pristine PHB nanofiber mats, and also the surface wettability. 28 Electrospun PAN nanofiber mats were decorated with ZnO/Ag heterostructure nanoparticles using reflux, blending and hydrothermal methods, in all cases uniformly dispersing the nanoparticles on the nanofiber surfaces. All three decoration methods resulted in good antibacterial properties against Escherichia coli (gram-negative) and Micrococcus luteus (gram-positive), suggesting this fast and inexpensive path to developing antibacterial nanofiber membranes for protective textiles and filtration.…”

Section: Zno On Nanofiber Substratesmentioning

confidence: 99%

Recent developments in electrospun ZnO nanofibers: A short review

Błachowicz

Ehrmann

2020

Journal of Engineered Fibers and Fabrics

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Especially for the potential use as sensors, but also in all other applications in which an interaction with the environment occurs, nanofibrous materials are advantageous due to their large specific surface area. An interesting material for electrospinning is the semiconductor zinc oxide (ZnO) which is often used in photoelectric or sensory applications. Nanofibers containing ZnO can be produced, for example, by electrospinning polyvinylpyrrolidone/zinc nitrate from a dimethylformamide/ethanol solution, followed by calcination to remove the organic phase. Alternatively, the polymer/semiconductor blended nanofibers can be used which are often less brittle, but on the other hand offer less contact between ZnO and the environment. Finally, decorating a nanofiber mat with ZnO offers another possibility to prepare nanofibers with ZnO surface. Possible applications of electrospun ZnO nanofibers or nanofiber mats include gas sensing, microwave absorption, photocatalytic degradation or enhancement of supercapacitor electrodes. This short review gives an overview of the most recent electrospinning and after-treatment techniques to create pure and blended ZnO nanofibers and presents the broad variety of possible applications of this well-known semiconductor with some still surprising properties.

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Enhanced piezoelectric response of hybrid biodegradable 3D poly(3-hydroxybutyrate) scaffolds coated with hydrothermally deposited ZnO for biomedical applications

Cited by 48 publications

References 40 publications

A Biodegradable and Recyclable Piezoelectric Sensor Based on a Molecular Ferroelectric Embedded in a Bacterial Cellulose Hydrogel

A Biodegradable and Recyclable Piezoelectric Sensor Based on a Molecular Ferroelectric Embedded in a Bacterial Cellulose Hydrogel

Electrical Stimulation Enabled via Electrospun Piezoelectric Polymeric Nanofibers for Tissue Regeneration

Recent developments in electrospun ZnO nanofibers: A short review

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