2021
DOI: 10.3390/biology10020135
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Abstract: Mechanical and electrical stimuli play a key role in tissue formation, guiding cell processes such as cell migration, differentiation, maturation, and apoptosis. Monitoring and controlling these stimuli on in vitro experiments is not straightforward due to the coupling of these different stimuli. In addition, active and reciprocal cell–cell and cell–extracellular matrix interactions are essential to be considered during formation of complex tissue such as myocardial tissue. In this sense, computational models … Show more

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Cited by 6 publications
(5 citation statements)
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References 106 publications
(219 reference statements)
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“…Our cell mechanical model assumes that cell internal deformations are a result of cell-cell and cell-ECM interactions [26]. The actin-myosin (AM) bundles, which are considered as a part of the cytoskeleton (CSK), are the main components that actively develop contractile forces within the cell, whereas other components of the CSK along with the cell membrane, act as resistive elements that oppose the cell internal deformation.…”
Section: Modeling Of Cell Migrationmentioning
confidence: 99%
See 2 more Smart Citations
“…Our cell mechanical model assumes that cell internal deformations are a result of cell-cell and cell-ECM interactions [26]. The actin-myosin (AM) bundles, which are considered as a part of the cytoskeleton (CSK), are the main components that actively develop contractile forces within the cell, whereas other components of the CSK along with the cell membrane, act as resistive elements that oppose the cell internal deformation.…”
Section: Modeling Of Cell Migrationmentioning
confidence: 99%
“…where 𝑡 is the cell-cycle progression time, and 𝑡 𝑚𝑎𝑡 is the time needed for the cell to complete the cell cycle [31]. The effects of the mechanical conditions, which can increase the rate of cell-cycle progression, are dependent on the cell's internal deformations [26]. So, the cell cycle time is dependent on the mechanical stimuli perceived by the cell at each time, 𝑡, which can be defined as:…”
Section: Modeling Of Cell Proliferationmentioning
confidence: 99%
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“…Computation is a useful tool for regulating this parameter. Urdeitx and Doneider used a piezoelectric fibered extracellular matrix in a 3D computational model [ 87 ] to calculate the intracellular force affected by the fiber. Computational models can be powerful tools for estimating precise cellular changes that connect differentiation.…”
Section: Somatic Stem Cellsmentioning
confidence: 99%
“…Using this approach, cells seeded onto piezoelectric polymeric membranes undergo a double stimulation. The first stimulation regards the electric stimulation due to the piezoelectric effect of the material under dynamic loading, and the second concerns the physical stretching of the membrane [ 18 ]. The impact of mechanical stimulation on stem cells’ commitment is indeed well known [ 19 , 20 ].…”
Section: Introductionmentioning
confidence: 99%