Enhanced Photothermal-Photodynamic Therapy by Indocyanine Green and Curcumin-Loaded Layered MoS2 Hollow Spheres via Inhibition of P-Glycoprotein

Li, Shuai; Yang, Shuping; Liu, Chong; He, Jintong; Li, Tian Tian; Fu, Changhui; Meng, Xianwei; Shao, Haibo

doi:10.2147/ijn.s275938

Cited by 27 publications

(22 citation statements)

References 35 publications

(15 reference statements)

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“…MRNA decreased significantly in the ICG and Cur @ MoS2 group, indicating that ICG and Cur @ MoS2 inhibited MDR1 transcription. In conclusion, the ICG and Cur @ MoS2 nanoparticles, under the action of PTT-PDT, have inhibited P-gp effectively, and may have great potential in the treatment of hepatocellular carcinoma [176].…”

Section: Gastrointestinal Cancersmentioning

confidence: 89%

Latest Innovations and Nanotechnologies with Curcumin as a Nature-Inspired Photosensitizer Applied in the Photodynamic Therapy of Cancer

Ailioaie

Litscher

2021

Pharmaceutics

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In the context of the high incidence of cancer worldwide, state-of-the-art photodynamic therapy (PDT) has entered as a usual protocol of attempting to eradicate cancer as a minimally invasive procedure, along with pharmacological resources and radiation therapy. The photosensitizer (PS) excited at certain wavelengths of the applied light source, in the presence of oxygen releases several free radicals and various oxidation products with high cytotoxic potential, which will lead to cell death in irradiated cancerous tissues. Current research focuses on the potential of natural products as a superior generation of photosensitizers, which through the latest nanotechnologies target tumors better, are less toxic to neighboring tissues, but at the same time, have improved light absorption for the more aggressive and widespread forms of cancer. Curcumin incorporated into nanotechnologies has a higher intracellular absorption, a higher targeting rate, increased toxicity to tumor cells, accelerates the activity of caspases and DNA cleavage, decreases the mitochondrial activity of cancer cells, decreases their viability and proliferation, decreases angiogenesis, and finally induces apoptosis. It reduces the size of the primary tumor, reverses multidrug resistance in chemotherapy and decreases resistance to radiation therapy in neoplasms. Current research has shown that the use of PDT and nanoformulations of curcumin has a modulating effect on ROS generation, so light or laser irradiation will lead to excessive ROS growth, while nanocurcumin will reduce the activation of ROS-producing enzymes or will determine the quick removal of ROS, seemingly opposite but synergistic phenomena by inducing neoplasm apoptosis, but at the same time, accelerating the repair of nearby tissue. The latest curcumin nanoformulations have a huge potential to optimize PDT, to overcome major side effects, resistance to chemotherapy, relapses and metastases. All the studies reviewed and presented revealed great potential for the applicability of nanoformulations of curcumin and PDT in cancer therapy.

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Section: Gastrointestinal Cancersmentioning

confidence: 89%

Latest Innovations and Nanotechnologies with Curcumin as a Nature-Inspired Photosensitizer Applied in the Photodynamic Therapy of Cancer

Ailioaie

Litscher

2021

Pharmaceutics

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“…Pollutant degradation [ 119] ICG&Cur@MoS 2 Hollow sphere --PTT, PDT, drug loading Cancer treatment [ 120] DOX@Apt-PEG-PDA- MoS 2 -Au-cRGD Nanosheet --Targeting, CDT, PTT, Drug loading Cancer treatment [ 125] MoS 2 @PDA-PEG/IgG Nanosheet --Bacteria-targeting, PTT Antibacterial [ 126] MoS 2 /rGO Defect-Rich vertical heterostructure --Bacterial capturing, Enzyme-like activities Antibacterial [ 127] Zn-MoS 2 -ZIF-8 p-n heterostructure 1.38 3.03 PTT, PDT, Ion releasing Antibacterial [84] Scheme 1. The summary illustration of the unique characteristics of 2D MoS 2 and its corresponding antibacterial mode.…”

Section: Oh Generationmentioning

confidence: 99%

2D Molybdenum Sulfide‐Based Materials for Photo‐Excited Antibacterial Application

Chen

Luo

Liu

et al. 2022

Adv Healthcare Materials

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Bacterial infections have seriously threatened human health and the abuse of natural or artificial antibiotics leads to bacterial resistance, so development of a new generation of antibacterial agents and treatment methods is urgent. 2D molybdenum sulfide (MoS 2 ) has good biocompatibility, high specific surface area to facilitate surface modification and drug loading, adjustable energy bandgap, and high near-infrared photothermal conversion efficiency (PCE), so it is often used for antibacterial application through its photothermal or photodynamic effects. This review comprehensively summarizes and discusses the fabrication processes, structural characteristics, antibacterial performance, and the corresponding mechanisms of MoS 2 -based materials as well as their representative antibacterial applications. In addition, the outlooks on the remaining challenges that should be addressed in the field of MoS 2 are also proposed.

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“…Cyanine dye also has photosensitizing characteristics [98]. Experimental reports regarding PDT with ICG and its combination with other chemical compounds, such as nanoparticles, for liver cancer have recently increased [36,99,100]. In biliary cancers, Hishikawa et al reported the usefulness of NIR fluorescence imaging and photodynamic therapy with ICG lactosomes in gallbladder cancer cell lines [101].…”

Section: Recent Pdd Using Ala and Icg-based Nir Fluorescence Imagingmentioning

confidence: 99%

Recent Advances in Photodynamic Imaging and Therapy in Hepatobiliary Malignancies: Clinical and Experimental Aspects

et al. 2021

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The therapeutic and diagnostic modalities of light are well known, and derivative photodynamic reactions with photosensitizers (PSs), specific wavelengths of light exposure and the existence of tissue oxygen have been developed since the 20th century. Photodynamic therapy (PDT) is an effective local treatment for cancer-specific laser ablation in malignancies of some organs, including the bile duct. Although curability for extrahepatic cholangiocarcinoma is expected with surgery alone, patients with unresectable or remnant biliary cancer need other effective palliative therapies, including PDT. The effectiveness of PDT for cholangiocarcinoma has been reported experimentally or clinically, but it is not the standard option now due to problems with accompanied photosensitivity, limited access routes of irradiation, tumor hypoxia, etc. Novel derivative treatments such as photoimmunotherapy have not been applied in the field hepatobiliary system. Photodynamic diagnosis (PDD) has been more widely applied in the clinical diagnoses of liver malignancies or liver vascularization. At present, 5-aminolevulinic acid (ALA) and indocyanine green (ICG) dyes are mainly used as PSs in PDD, and ICG has been applied for detecting liver malignancies or vascularization. However, no ideal tools for combining both PDD and PDT for solid tumors, including hepatobiliary malignancies, have been clinically developed. To proceed with experimental and clinical trials, it is necessary to clarify the effective photosensitive drugs that are feasible for photochemical diagnosis and local treatment.

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Enhanced Photothermal-Photodynamic Therapy by Indocyanine Green and Curcumin-Loaded Layered MoS2 Hollow Spheres via Inhibition of P-Glycoprotein

Cited by 27 publications

References 35 publications

Latest Innovations and Nanotechnologies with Curcumin as a Nature-Inspired Photosensitizer Applied in the Photodynamic Therapy of Cancer

Latest Innovations and Nanotechnologies with Curcumin as a Nature-Inspired Photosensitizer Applied in the Photodynamic Therapy of Cancer

2D Molybdenum Sulfide‐Based Materials for Photo‐Excited Antibacterial Application

Recent Advances in Photodynamic Imaging and Therapy in Hepatobiliary Malignancies: Clinical and Experimental Aspects

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