Enhanced photodynamic therapy/photothermo therapy for nasopharyngeal carcinoma via a tumour microenvironment-responsive self-oxygenated drug delivery system

Wu, Nan; Tu, Yaojie; Fan, Guoxin; Ding, Jiahui; Luo, Jun; Wang, Wei; Zhang, Chong; Yuan, Caiyan; Zhang, Handan; Chen, Pei; Tan, Songwei; Xiao, Hongjun

doi:10.1016/j.ajps.2022.01.002

Cited by 19 publications

(7 citation statements)

References 62 publications

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“…In comparison to the TEM results, the particle size as observed by DLS was a little larger. This is probably due to the presence of a solvation layer on the particle surface and the solvation layer may impact the observed particle size (Wu et al., 2022 ). The particle size of PTX@TPGS-PBTE remained stable during incubation in PBS and FBS for 96 h at 37 °C, indicating good stability of PTX@TPGS-PBTE under physiological conditions ( Figure 2C ).…”

Section: Resultsmentioning

confidence: 99%

Paclitaxel-loaded ROS-responsive nanoparticles for head and neck cancer therapy

Zhang

Fan

et al. 2023

Drug Delivery

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High intracellular reactive oxygen species (ROS) level is characteristic of cancer cells and could act as a target for the efficient targeted drug delivery for cancer treatment. Consequently, biomaterials that react to excessive levels of ROS are essential for biomedical applications. In this study, a novel ROS-responsive polymer based on D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) and poly (β-thioester) (TPGS-PBTE) was synthesized for targeted delivery of the first-line antineoplastic drug, paclitaxel (PTX). The resultant TPGS-PBTE NPs showed good ROS-responsive capability in size change and drug release. Compared to PTX, PTX-loaded nanoparticles (PTX@TPGS-PBTE NPs) showed enhanced cytotoxicity and higher level of apoptosis toward squamous cell carcinoma (SCC-7) cells. Tumor-targeted delivery of the NPs was also observed, especially after being modified with a tumor-targeting peptide, cRGD. Enhanced tumor growth inhibition was also observed in head and neck cancer SCC-7 murine models. In summary, PTX@TPGS-PBTE NPs can achieve good therapeutic effects of PTX against head and neck cancer both in vitro and in vivo, especially when modified by cRGD for active targeting, which enriched the application of ROS responsive system utilized in the delivery of anticancer drugs.

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Section: Resultsmentioning

confidence: 99%

Paclitaxel-loaded ROS-responsive nanoparticles for head and neck cancer therapy

Zhang

Fan

et al. 2023

Drug Delivery

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“…Irradiating the construct with 808 nm resulted in a significant raise in the temperature (PTT) that was cytotoxic and triggered the release of indocyanine green from the lipid NPs. The subsequent 670 nm irradiation produced ROS that mediated the caspase‐dependent apoptotic nasopharyngeal cancer cell death both at the in vitro and in vivo levels [40]. Sono‐PDT was also combined with PTT.…”

Section: How Nanotechnology Can Advance Pdtmentioning

confidence: 99%

Nanotechnology and photodynamic therapy from a clinical perspective

Gaber

Fadel

2022

Transl Biophotonics

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Photodynamic therapy (PDT) is currently applied clinically in many medical centers worldwide. The clinical outcomes are from one side satisfying and from the other side highlighting the areas of further development. Issues like hydrophobicity of the photosensitizer (PS), uncontrolled distribution and limited tissue penetration of the accompanying light sources triggered the interest of many research groups. Nanotechnology outstood among the various suggested enhancement solutions. In this review, the rationale behind using nanotechnology is discussed. Light is shed on the status of nanotechnology from approval for clinical use. Clinical studies of PS‐loaded nanoparticles are summarized and the challenges facing the progress of those systems are enumerated.

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“…The main objective of tissue engineering is the promotion of the growth of new tissues using biomaterials, cells, and different signaling molecules for the restoration of damaged tissues. It involves maintaining, restoring, and improving various tissues of the body like skin tissue, periodontal tissue, heart valve tissue, nerve tissue, vascular tissue or bone, and cartilage tissue (Wu et al, 2022). The regeneration of muscle, blood vessels, skin, and repair of nerves and cartilages have also been performed by PHAs.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Polyhydroxyalkanoates, the Biopolymers of Microbial Origin- A Review

Ranganadhareddy¹,

Chandrsekhar²

2022

J Biochem Technol

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Because petroleum-based plastics are not biodegradable, as well as the energy they require in their production, the rising plastic substantially contributes to the depletion of the environment. In contrast to synthetic plastics, polyhydroxyalkanoates (PHAs) are sustainable and eco-friendly bioplastics. A variety of microorganisms, such as fungi, bacteria, and algae, can be used to entirely synthesize PHAs. Enhanced biodegradability, biocompatibility, as well as other mechano-chemical properties are some of the promising properties of value-added biopolymers. It was also shown that PHA polymers have different properties depending on their chemical composition (units of monomer) and substrates. As an alternative to petroleum-based polymers, PHAs have great promise and need further study to determine how to economically produce and utilize them. Various applications of microbially synthesized PHAs are described in the review. Several microbial groups have also been shown to synthesize these biopolymers by genetic regulation. Also revealed in this review are the potential biomedical, environmental, and industrial applications of this biopolymer.

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Enhanced photodynamic therapy/photothermo therapy for nasopharyngeal carcinoma via a tumour microenvironment-responsive self-oxygenated drug delivery system

Cited by 19 publications

References 62 publications

Paclitaxel-loaded ROS-responsive nanoparticles for head and neck cancer therapy

Paclitaxel-loaded ROS-responsive nanoparticles for head and neck cancer therapy

Nanotechnology and photodynamic therapy from a clinical perspective

Polyhydroxyalkanoates, the Biopolymers of Microbial Origin- A Review

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