Enhanced pH and thermal stability, solubility and antioxidant activity of resveratrol by nanocomplexation with α-lactalbumin

Liu, Yuexiang; Fan, Yuting; Gao, Luyu; Zhang, Yuzhu; Jiang, Yi

doi:10.1039/c8fo01172a

Cited by 61 publications

(14 citation statements)

References 33 publications

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“…When resveratrol was loaded by zein–pectin core / shell nanoparticles, they became stable to aggregation from pH 2 to 7 and exhibited good heat stability . Similar results were obtained by other groups . Liang et al .…”

Section: Stabilitysupporting

confidence: 79%

Resveratrol: a review of plant sources, synthesis, stability, modification and food application

2019

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Resveratrol, a stilbene molecule belonging to the polyphenol family, is usually extracted from a great many natural plants. The technologies of preparation and extraction methods are developing rapidly. As resveratrol has many beneficial properties, it has been widely utilized in food and medicine industry. In terms of its structure, it is susceptible to degradation and can undergo chemical changes during food processing. Different studies have therefore given more attention to various aspects of resveratrol, including anti-aging, anti-oxidant, and anti-cancer activity. This review classifies the study of resveratrol, considers plant sources, synthesis, stability, common reactions, and food applications, and provides references to boost its food and medical utilization. SYNTHESISSince the discovery of natural resveratrol by researchers, chemist have made many attempts at the chemical synthesis / biosynthesis of resveratrol (Fig. 2). 15

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Section: Stabilitysupporting

confidence: 79%

Resveratrol: a review of plant sources, synthesis, stability, modification and food application

2019

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“…235 nm and polydispersity index 0.24 showed improved in vitro antioxidant activity as well as lower IC 50 values (by 32%) related to antiproliferative activity tested using human hepatocarcinoma Bel-7402 cells compared to free RES, suggesting that such nanoformulation of RES could be used in functional foods and beverages as well as in DISs and pharmaceutical products [157]. The aqueous solubility of RES from α-lactalbumin (α-Lalb)-RES nanocomplexes was 32-fold higher than that of free RES, and the nanocomplexes considerably improved the antioxidant chemical stability under storage, especially at pH 8.0 and high temperature, and showed superb in vitro antioxidant activity compared to free RES, suggesting that α-Lalb as a nanoscale carrier could effectively deliver lipophilic nutraceuticals in the functional food, biomedical, and pharmaceutical products [158]. The protection of light-sensitive AST, a carotenoid with the most potent antioxidant activity, from photodegradation achieved by its inclusion in different hierarchically assembled nano- and microstructures in order to produce model foods for humans and fishes decreased as follows: NEs > carrageenan-coated NEs > CS coated NEs, and CS beads provided higher protection to AST than alginate beads.…”

Section: Antioxidantsmentioning

confidence: 99%

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

2019

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Dietary supplements and foods for special medical purposes are special medical products classified according to the legal basis. They are regulated, for example, by the European Food Safety Authority and the U.S. Food and Drug Administration, as well as by various national regulations issued most frequently by the Ministry of Health and/or the Ministry of Agriculture of particular countries around the world. They constitute a concentrated source of vitamins, minerals, polyunsaturated fatty acids and antioxidants or other compounds with a nutritional or physiological effect contained in the food/feed, alone or in combination, intended for direct consumption in small measured amounts. As nanotechnology provides “a new dimension” accompanied with new or modified properties conferred to many current materials, it is widely used for the production of a new generation of drug formulations, and it is also used in the food industry and even in various types of nutritional supplements. These nanoformulations of supplements are being prepared especially with the purpose to improve bioavailability, protect active ingredients against degradation, or reduce side effects. This contribution comprehensively summarizes the current state of the research focused on nanoformulated human and veterinary dietary supplements, nutraceuticals, and functional foods for special medical purposes, their particular applications in various food products and drinks as well as the most important related guidelines, regulations and directives.

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“…Meanwhile, these peaks also appeared in the XRD pattern of physical mixtures of Res and zein-MSC NPs. In contrast, all these characteristic peaks of Res could not be observed for Res-zein-MSC NPs, indicating the amorphous status of Res after encapsulation [35].…”

Section: Xrdmentioning

confidence: 80%

A Novel Zein-Based Composite Nanoparticles for Improving Bioaccessibility and Anti-Inflammatory Activity of Resveratrol

Liu

Zhang

Liu

et al. 2021

Foods

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A microbial transglutaminase-induced cross-linked sodium caseinate (MSC) was used to stabilize zein nanoparticles, and the study was to investigate whether zein-MSC nanoparticles (zein-MSC NPs) can be used as an encapsulation carrier for resveratrol. A group of resveratrol-loaded zein-MSC nanoparticles (Res-zein-MSC NPs) with varying zein to Res mass ratios was first prepared. The particle sizes and zeta-potentials were in the ranges from 215.00 to 225.00 nm and from −29.00 to −31.00 mV. The encapsulation efficiency (EE) of Res was also influenced by the zein to Res mass ratio, and the encapsulated Res existed in an amorphous form. The major interactions between Res and zein-MSC NPs were hydrogen bonding and hydrophobic interaction. Furthermore, compared with free Res, the photo-stability and bioaccessibility of Res-zein-MSC NPs were significantly improved. The cellular studies also showed that Res-zein-MSC NPs exhibited lower cytotoxicity and desirable anti-inflammatory activity.

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Enhanced pH and thermal stability, solubility and antioxidant activity of resveratrol by nanocomplexation with α-lactalbumin

Cited by 61 publications

References 33 publications

Resveratrol: a review of plant sources, synthesis, stability, modification and food application

Resveratrol: a review of plant sources, synthesis, stability, modification and food application

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

A Novel Zein-Based Composite Nanoparticles for Improving Bioaccessibility and Anti-Inflammatory Activity of Resveratrol

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