Enhanced permeability and retention effect: A key facilitator for solid tumor targeting by nanoparticles

Shinde, Vinod Ravasaheb; Revi, Neeraja; Murugappan, Sivasubramanian; Singh, Surya Prakash; Rengan, Aravind Kumar

doi:10.1016/j.pdpdt.2022.102915

Cited by 57 publications

(47 citation statements)

References 104 publications

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“…Fluorescence images were captured at 0, 24, and 48 h for each group; relative intensity is displayed in the bar graphs (Figure D). This increased uptake of NPs in the zebrafish may be due to the chorion surface structure modification and increased retention permeability with longer exposure time. , This experiment proved that the successful incorporation of polyphenols and IR-775 dye into the hydrophobic core region of PLA having a self-assembled structure could serve as a bioimaging agent in theranostic approaches. The biocompatibility observed when tested in zebrafish embryos correlates with the in vitro results.…”

Section: Resultsmentioning

confidence: 99%

Terminalia chebula Polyphenol and Near-Infrared Dye-Loaded Poly(lactic acid) Nanoparticles for Imaging and Photothermal Therapy of Cancer Cells

Pebam¹,

Rajalakshmi²,

Gangopadhyay³

et al. 2022

ACS Appl. Bio Mater.

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Photothermal/photodynamic therapies (PTT/ PDT) are multimodal approaches employing near-infrared (NIR) light-responsive photosensitizers for cancer treatment. In the current study, IR-775, a hydrophobic photosensitizer, was used in combination with a polyphenols (p)-rich ethyl acetate extract from Terminalia chebula to treat cancer. IR-775 dye and polyphenols were encapsulated in a poly(lactic acid) polymeric nanosystem (PpIR NPs) to increase the cell bioavailability. The hydrodynamic diameter of PpIR NPs is 142.6 ± 2 nm and exhibited physical stability. The nanosystem showed enhanced cellular uptake in a lung cancer cell line (A549). Cell cytotoxicity results indicate that PpIR NPs showed more than 82.46 ± 3% cell death upon NIR light treatment compared to the control groups. Both PDT and PTT generate reactive oxygen species (ROS) and cause hyperthermia, thereby enhancing cancer cell death. Qualitative and quantitative analyses have depicted that PpIR NPs with NIR light irradiation have decreased protein expression of HSP70 and PARP, and increased γ-H2AX, which collectively lead to cell death. After NIR light irradiation, the relative gene expression patterns of HSP70 and CDK2Na were also downregulated. Further, PpIR NPs uptake has been studied in 3D cells and in ovo bioimaging in zebrafish models. In conclusion, the PpIR NPs show good cancer cell cytotoxicity and present a potential nanosystem for bioimaging.

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Section: Resultsmentioning

confidence: 99%

Terminalia chebula Polyphenol and Near-Infrared Dye-Loaded Poly(lactic acid) Nanoparticles for Imaging and Photothermal Therapy of Cancer Cells

Pebam¹,

Rajalakshmi²,

Gangopadhyay³

et al. 2022

ACS Appl. Bio Mater.

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“…The current targeting strategies mainly include active targeting, passive targeting, and stimulation response release. Previous studies have proved that nanoparticles with a size range (10–200 nm) can enrich at the tumor site by EPR effects [ 145 ]. The surface of nanoparticles can also be modified with some specific targeting groups to actively target tumor cells by combining with receptors on the surface of tumor cells.…”

Section: Enhanced Targeting Performance Of Mtkis Nanoparticlesmentioning

confidence: 99%

Multi-target tyrosine kinase inhibitor nanoparticle delivery systems for cancer therapy

Xu¹,

Ye²,

Qing³

et al. 2022

Materials Today Bio

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“…Enhanced permeability and retention effect (EPR) is one of the most important phenomena for the selective accumulation of the NCs at the target tissue through the passive targeting systems. The rationale behind the selective accumulation of NCs through the EPR is due to the formation of leaky blood vessels in the fast-growing tumor tissues. , These leaky blood vessels will enhance the selective accumulation of the NCs in the tumor regions compared to the intact blood vessels in the normal tissues. , Figure depicts the comparison between normal and tumor vasculature …”

Section: Introductionmentioning

confidence: 99%

“…The rationale behind the selective accumulation of NCs through the EPR is due to the formation of leaky blood vessels in the fast-growing tumor tissues. 15,16 These leaky blood vessels will enhance the selective accumulation of the NCs in the tumor regions compared to the intact blood vessels in the normal tissues. 12,14 Figure 1 depicts the comparison between normal and tumor vasculature.…”

Section: ■ Introductionmentioning

confidence: 99%

“…12,14 Figure 1 depicts the comparison between normal and tumor vasculature. 15 siRNA delivery using biocompatible NCs will provide the following advantages: (i) protection from RNase degradation and renal clearance, (ii) enhances the stability and cellular uptake of siRNA, (iii) improves endosomal escape and tumortargeting efficacy, and (iv) reduces toxicity and immune system response with minimal side. 12,17,18 Organic NCs include synthetic polymers such as polyethylenimine (PEI), poly-L-lysine (PLL), dendrimers, and natural polymers such as chitosan, and cyclodextrin.…”

Section: ■ Introductionmentioning

confidence: 99%

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Recent Advancements in the Design of Nanodelivery Systems of siRNA for Cancer Therapy

et al. 2022

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RNA interference (RNAi) has increased the possibility of restoring RNA drug targets for cancer treatment. Small interfering RNA (siRNA) is a promising therapeutic RNAi tool that targets the defective gene by inhibiting its mRNA expression and stopping its translation. However, siRNAs have flaws like poor intracellular trafficking, RNase degradation, rapid kidney filtration, off-targeting, and toxicity, which limit their therapeutic efficiency. Nanocarriers (NCs) have been designed to overcome such flaws and increase antitumor activity. Combining siRNA and anticancer drugs can give synergistic effects in cancer cells, making them a significant gene-modification tool in cancer therapy. Our discussion of NCs-mediated siRNA delivery in this review includes their mechanism, limitations, and advantages in comparison with naked siRNA delivery. We will also discuss organic NCs (polymers and lipids) and inorganic NCs (quantum dots, carbon nanotubes, and gold) that have been reported for extensive delivery of therapeutic siRNA to tumor sites. Finally, we will conclude by discussing the studies based on organic and inorganic NCs-mediated siRNA drug delivery systems conducted in the years 2020 and 2021.

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Enhanced permeability and retention effect: A key facilitator for solid tumor targeting by nanoparticles

Cited by 57 publications

References 104 publications

Terminalia chebula Polyphenol and Near-Infrared Dye-Loaded Poly(lactic acid) Nanoparticles for Imaging and Photothermal Therapy of Cancer Cells

Terminalia chebula Polyphenol and Near-Infrared Dye-Loaded Poly(lactic acid) Nanoparticles for Imaging and Photothermal Therapy of Cancer Cells

Multi-target tyrosine kinase inhibitor nanoparticle delivery systems for cancer therapy

Recent Advancements in the Design of Nanodelivery Systems of siRNA for Cancer Therapy

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