Enhanced Peptide-Binding Capacities of Small Intestinal Brush Border Membranes in Celiac Disease

Bolte, Gabriele; Seilmeier, Werner; Wieser, Herbert; Holm, K; Beuermann, K.; Newport, Beate; Stern, Martin

doi:10.1203/00006450-199912000-00010

Cited by 9 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The binding of gliadin to the brush border membrane in intestinal cell lines and intestinal tissue could be substantially upregulated by interferon γ (IFNγ),14 15 suggesting a modulatory role for this cytokine and possibly other associating components in the uptake and further processing of gliadin peptides. An interesting feature with respect to gliadin uptake is the intracellular accumulation of gliadin peptides in intracellular compartments of CD enterocytes as compared with control enterocytes 16 17…”

Section: Introductionmentioning

confidence: 99%

Endocytotic segregation of gliadin peptide 31-49 in enterocytes

Zimmer

Fischer²,

Mothes

et al. 2009

Gut

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Endocytotic segregation of gliadin peptide 31-49 in enterocytes

Zimmer

Fischer²,

Mothes

et al. 2009

Gut

View full text Add to dashboard Cite

show abstract

“…Overweight children run an increased risk to become obese as children and also overweight/obese as adults [5]. A child with obesity is at risk to develop a wide spectrum of adiposity-related diseases and comorbid conditions.…”

Section: Introductionmentioning

confidence: 99%

Overweight among Four-Year-Old Children in Relation to Early Growth Characteristics and Socioeconomic Factors

et al. 2010

View full text Add to dashboard Cite

Objectives. To assess early growth characteristics and socioeconomic factors of children in relation to body mass index (BMI) and presence of overweight among four-year-old children. Methods. Two Child Health Centres (CHC) participated in the study. They were selected to obtain two populations of children featuring divergent socio-economic characteristics. Growth data registered at the CHCs from birth to the 4-year check-up were recovered. Overweight was defined by the BMI cut-offs established by IOTF. BMI values expressed as BMI standard deviation score (BMISDS) were used for analysis. Results. At the 4-year check-up, the BMISDS and the proportion of children with overweight (including the obese) were significantly higher in the district with lower socio-economic status. High BMI at birth and low socio-economic status of the population in the CHC-district were shown to be independent determinants for overweight and BMISDS at four years of age. Conclusions. More research is needed to understand the mechanisms and how intervention programs should be designed in order to prevent the development of overweight and obesity in children.

show abstract

“…Other methods have been developed to identify children who are at high risk for becoming overweight and/or developing adverse cardiometabolic outcome; such methods include the use of a single risk factor, combining risk factors, and developing risk models, risk algorithms, and risk charts. For example, in both Sweden and the United States, risk charts have been developed to predict adult overweight based on a single BMI measurement during childhood [ 54 , 55 ]. Another study performed in the United States reported crude risk estimates of being overweight by the age of 12 years based on one, two, or three BMI values measured between 2 and 4½ years of age [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Prediction of Preadolescent Overweight and Poor Cardiometabolic Outcome in Children up to 6 Years of Age: Research Protocol

Kroon

Wijga²,

Vergouwe³

et al. 2016

JMIR Res Protoc

View full text Add to dashboard Cite

BackgroundDynamic risk estimations may enable targeting primary prevention of overweight and overweight-related adverse cardiometabolic outcome in later life, potentially serving as a valuable addition to universal primary prevention. This approach seems particularly promising in young children, as body mass index (BMI) changes at a young age are highly predictive of these outcomes, and parental lifestyle interventions at a young age are associated with improved long-term outcome.ObjectiveThis paper describes the design of our study, which aims to develop digitized tools that can be implemented in the Dutch Child Health Care (CHC) system or by pediatricians for children up to 6 years of age. These tools will enable (1) dynamically predicting the development of overweight, hypertension or prehypertension, low high-density lipoprotein cholesterol (HDL-C) values, and high total cholesterol to HDL-C ratio by early adolescence and (2) identifying children who are likely to have poor cardiometabolic outcome by the age of 5-6 years and by the age of 10 years.MethodsData will be obtained from the Generation R (n=7893) and Prevention and Incidence of Asthma and Mite Allergy (PIAMA; n=3963) cohorts, two Dutch prenatally recruited cohorts. We will select candidate predictors that can be assessed during the first visit and/or during subsequent visits to the CHC center or pediatrician, including sex; parental age, education level, and BMI; smoking exposure; ethnicity; birth weight; gestational age; breastfeeding versus formula feeding; and growth data through the age of 6 years. We will design dynamic prediction models that can be updated with new information obtained during subsequent CHC visits, allowing each measurement to be added to the model. Performance of the model will be assessed in terms of discrimination and calibration. Finally, the model will be validated both internally and externally using the combined cohort data and then converted into a computer-assisted tool called ProCOR (Prediction Of Child CardiOmetabolic Risk).ResultsThis is an ongoing research project financed by the Dutch government. The first results are expected in 2016.ConclusionsThis study may contribute to the national implementation of digitized tools for assessing the risk of overweight and related cardiometabolic outcome in young children, enabling targeted primary prevention, ultimately yielding relevant health gains and improved resource allocation.

show abstract

Enhanced Peptide-Binding Capacities of Small Intestinal Brush Border Membranes in Celiac Disease

Cited by 9 publications

References 30 publications

Endocytotic segregation of gliadin peptide 31-49 in enterocytes

Endocytotic segregation of gliadin peptide 31-49 in enterocytes

Overweight among Four-Year-Old Children in Relation to Early Growth Characteristics and Socioeconomic Factors

Prediction of Preadolescent Overweight and Poor Cardiometabolic Outcome in Children up to 6 Years of Age: Research Protocol

Contact Info

Product

Resources

About