Enhanced oxidative stress and endothelial dysfunction in streptozotocin-diabetic rats exposed to fine particles

Yu, Lei; Hwang, J. S.; Chan, Chang-Chuan; Lee, Chung Te; Cheng, Tsun‐Jen

doi:10.1016/j.envres.2005.03.011

Cited by 66 publications

(39 citation statements)

References 58 publications

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“…C-reactive protein (CRP) is another known marker of vascular inflammation (52). Studies in literature have reported both no change (67) and an increase (68) in CRP levels in STZ-treated diabetic rats in comparison to normal rats. The present study did not observe an increase in blood levels of CRP in STZ-treated diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

Effect of chromium niacinate and chromium picolinate supplementation on lipid peroxidation, TNF-α, IL-6, CRP, glycated hemoglobin, triglycerides, and cholesterol levels in blood of streptozotocin-treated diabetic rats

Jain

Rains

Croad

2007

Free Radical Biology and Medicine

148

108

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SUMMARYChromium (Cr 3+ ) supplementation facilitate normal protein, fat and carbohydrate metabolism, and is widely used by public in many countries. This study examined the effect of chromium niacinate (Cr-N) or chromium picolinate (Cr-P) supplementation on lipid peroxidation (LP), TNF-α, IL-6, CRP, glycosylated hemoglobin (HbA 1 ), cholesterol and triglycerides (TG) in diabetic rats. Diabetes (D) was induced in Sprague Dawley rats by streptozotocin (STZ) (ip, 65 mg/kg BW). Control buffer, Cr-N or Cr-P (400 µg Cr/Kg BW) was administered by gavages daily for 7 wks. Blood was collected by heart puncture using light anesthesia. Diabetes caused a significant increase in blood levels of TNF-α, IL-6, glucose, HbA 1 , cholesterol, TG and LP. Compared with D, Cr-N supplementation lowered the blood levels of TNF-α (p=0.04), IL-6 (p=0.02), CRP (p=0.02) LP (p=0.01), HbA 1 (p=0.02), TG (p=0.04) and cholesterol (p=0.04). Compared with D, Cr-P supplementation showed a decrease in TNF-α (p=0.02), IL-6 (p=0.02) and LP (p=0.01). Chromium niacinate lowers blood levels of pro-inflammatory cytokines (TNF-α, IL-6, CRP), oxidative stress and lipids levels in diabetic rats, and appears to be more effective form of Cr 3+ -supplementation. This study suggests that Cr 3+ -supplementation can lower risk of vascular inflammation in diabetes.

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Section: Discussionmentioning

confidence: 99%

Effect of chromium niacinate and chromium picolinate supplementation on lipid peroxidation, TNF-α, IL-6, CRP, glycated hemoglobin, triglycerides, and cholesterol levels in blood of streptozotocin-treated diabetic rats

Jain

Rains

Croad

2007

Free Radical Biology and Medicine

148

108

View full text Add to dashboard Cite

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“…Thus, from the viewpoint of the LDL-C-reducing effect, pitavastatin treatment for 12 months is unlikely to have regressed atherosclerotic lesions in our patients. It has been reported that oxidized LDL and 8-OHdG contribute to atherogenetic processes by inducing vascular endothelial dysfunction 32,33) . Therefore, the improvement in CAVI observed in our study may be consistent mainly with the improvement of endothelial dysfunction but not the regression of a organic lesion.…”

Section: Discussionmentioning

confidence: 99%

Effects of Pitavastatin, a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, on Cardio-Ankle Vascular Index in Type 2 Diabetic Patients

Miyashita

Endo

Saiki

et al. 2009

J Atheroscler Thromb

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Aim: A novel device has been developed for measuring the cardio-ankle vascular index (CAVI) as an indicator of arterial stiffness. In this study, we evaluated the effect of pitavastatin on CAVI in type 2 diabetic patients. Methods: Forty-five type 2 diabetes mellitus patients with low-density lipoprotein cholesterolemia were enrolled and treated with pitavastatin 2 mg/day for 12 months. Before and after pitavastatin administration, HbA1c, serum lipids, serum malondialdehyde-LDL (MDA-LDL), urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and CAVI were measured.

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“…Another possibility is that endothelial function is improved. Oxidative stress is reported to be the cause of endothelial dysfunction 24) , and high levels of 8-OHdG are reported to contribute to atherogenetic processes by vascular endothelial dysfunction 25,26) . So, the improvement of CAVI recognized in our study might be due to not only the regression of organic lesions but also the improvement of endothelial dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Effects of Olmesartan, an Angiotensin II Receptor Blocker, and Amlodipine, a Calcium Channel Blocker, on Cardio-Ankle Vascular Index (CAVI) in Type 2 Diabetic Patients with Hypertension

Miyashita

Saiki

Endo

et al. 2009

JAT

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Aim: Recently, a novel device for measuring the cardio-ankle vascular index (CAVI) as an arterial stiffness parameter has been developed. In this study, we evaluated the effect of angiotensin receptor blocker (ARB) and calcium channel (Ca) blocker on CAVI in type 2 diabetic patients with hypertension. Methods: Seventy type 2 diabetes mellitus patients with hypertension were enrolled and randomly divided into two groups. One group was administered olmesartan medoxomil 10 mg/day for 12 months (ARB group), and the other group was administered amlodipine besilate 5 mg/day for 12 months (Ca blocker group). Results: In the ARB group, a significant decrease in CAVI was observed after 12 months; however, no significant change in CAVI was observed in the Ca blocker group although changes in blood pressure were almost the same. By simple regression analyses, CAVI changes correlated positively with 8-OHdG changes. Conclusions: Olmesartan, an ARB, improved arterial stiffness more than amlodipine, and this effect might be due to not only the blood pressure-lowering effect but also to reducing the potential of oxidative stress recognized in olmesartan. J Atheroscler

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Enhanced oxidative stress and endothelial dysfunction in streptozotocin-diabetic rats exposed to fine particles

Cited by 66 publications

References 58 publications

Effect of chromium niacinate and chromium picolinate supplementation on lipid peroxidation, TNF-α, IL-6, CRP, glycated hemoglobin, triglycerides, and cholesterol levels in blood of streptozotocin-treated diabetic rats

Effect of chromium niacinate and chromium picolinate supplementation on lipid peroxidation, TNF-α, IL-6, CRP, glycated hemoglobin, triglycerides, and cholesterol levels in blood of streptozotocin-treated diabetic rats

Effects of Pitavastatin, a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, on Cardio-Ankle Vascular Index in Type 2 Diabetic Patients

Effects of Olmesartan, an Angiotensin II Receptor Blocker, and Amlodipine, a Calcium Channel Blocker, on Cardio-Ankle Vascular Index (CAVI) in Type 2 Diabetic Patients with Hypertension

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