Enhanced Oxidant Stress Under Acute Decompensated Congestive Heart Failure Exacerbates Left Ventricular Remodeling at its Stable Phase

Kunishige, Megumi; Kijima, Yasufumi; Sakai, Tomohiro; Akutagawa, Osamu; Matsuo, Akiko; Nishibe, Akira; Nakagawa, Yusuke; Hata, Tomoko

doi:10.1016/j.cardfail.2006.08.120

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“…It is mainly caused by the pathological changes due to left ventricular remodeling, which leads to ventricular expanding and left ventricular ejection fraction decreasing (Kunishige et al, 2006). At present, it is thought that activation of neuroendocrine is the most important cause of ventricular remodeling in chronic heart failure, and is also an important reason for the development and deterioration of heart failure, and the activation of renin-angiotensin-aldosterone system (RAAS) is the most important (Lin et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Effects of warming yang and invigorating qi prescription on renin-angiotensin-aldosterone system in rats with heart failure after myocardial infarction

Han¹,

Wang²,

et al. 2017

Food Sci. Technol

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This study investigated the effects of warming yang and invigorating qi prescription on renin-angiotensin-aldosterone system (RAAS) in rats with heart failure after myocardial infarction. 126 rats were randomly divided into model group, sham operation, warming yang, invigorating qi, warming yang+invigorating qi, digoxin and captopril group for respective treatment. After intervention for 6, 8 and 10 weeks, the left ventricular ejection fraction (LVEF) was calculated, and the plasma renin, angiotensin II and aldosterone levels were measured. Results showed that, after 6, 8 and 10 weeks, LVEF in warming yang, invigorating qi, warming yang+invigorating qi and captopril group was significantly higher than model group (P < 0.05), and the plasma renin, angiotensin II and aldosterone levels in warming yang, invigorating qi, warming yang+invigorating qi and captopril groups were significantly lower than model group (P < 0.05). Renin angiotensin II and aldosterone levels in invigorating qi, warming yang+invigorating qi and captopril groups after 10 weeks was significantly lower than after 6 weeks (P < 0.05); aldosterone level in captopril groups after 10 weeks was significantly lower than after 6 weeks (P < 0.05). Warming yang and invigorating qi prescription can improve LVEF in rats with heart failure after myocardial infarction, which may be related with the inhibition of RAAS activation.Keywords: warming yang; invigorating qi; heart failure; renin-angiotensin-aldosterone system. Practical Application: Traditional Chinese medicine warming yang and invigorating qi prescription can be used for treating heart failure after myocardial infarction.

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Section: Introductionmentioning

confidence: 99%