Enhanced Osteogenic Differentiation of Pluripotent Stem Cells via γ-Secretase Inhibition

Helmi, Summer A.; Rohani, Leili; Zaher, Ahmed Ragheb; Hawary, Youssry M. El; Rancourt, Derrick E.

doi:10.3390/ijms22105215

Cited by 8 publications

(3 citation statements)

References 80 publications

(84 reference statements)

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“…Pluripotent Stem Cells Regenerative Application Induced PSCs (iPSCs) attracted a great deal of attention regarding their potential applications in regenerative medicine for transplantation, in vitro disease modeling, and drug screening [282]. They are remarkable potential bio-systems able to differentiate into osteoblasts and osteocytes [283]. In recent years, bone tissue engineering has been introduced as a novel strategy for repairing bone defects and combining SCs and growth factors with a porous biocompatible and biodegradable scaffold.…”

Section: Embryonic Stem Cellsmentioning

confidence: 99%

Multifunctional Self-Assembled Peptide Hydrogels for Biomedical Applications

et al. 2023

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Self-assembly is a growth mechanism in nature to apply local interactions forming a minimum energy structure. Currently, self-assembled materials are considered for biomedical applications due to their pleasant features, including scalability, versatility, simplicity, and inexpensiveness. Self-assembled peptides can be applied to design and fabricate different structures, such as micelles, hydrogels, and vesicles, by diverse physical interactions between specific building blocks. Among them, bioactivity, biocompatibility, and biodegradability of peptide hydrogels have introduced them as versatile platforms in biomedical applications, such as drug delivery, tissue engineering, biosensing, and treating different diseases. Moreover, peptides are capable of mimicking the microenvironment of natural tissues and responding to internal and external stimuli for triggered drug release. In the current review, the unique characteristics of peptide hydrogels and recent advances in their design, fabrication, as well as chemical, physical, and biological properties are presented. Additionally, recent developments of these biomaterials are discussed with a particular focus on their biomedical applications in targeted drug delivery and gene delivery, stem cell therapy, cancer therapy and immune regulation, bioimaging, and regenerative medicine.

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Section: Embryonic Stem Cellsmentioning

confidence: 99%

Multifunctional Self-Assembled Peptide Hydrogels for Biomedical Applications

et al. 2023

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“…When cognate ligands on the surface of adjacent cells bind to the receptor, the extracellular and transmembrane parts of the Notch receptor are hydrolyzed by TACE and γ-secretase, respectively, causing the intracellular part of the Notch receptor (NICD) to detach from the cell membrane and move into the nucleus in which NICD interacts with RBPJ and MAML to convert transcriptional repressors into activators, activating gene expression of downstream HES family, HEY family, etc. The Notch downstream gene Hes-1 can interact with Runx2 and enhance its transcriptional activity, and then, MAML, an activator of the Notch pathway, has been demonstrated to activate Runx2 transcription in bone [ 93 ].…”

Section: Signal Pathways Involving Lncrna-mediated Osteogenesismentioning

confidence: 99%

The management of bone defect using long non-coding RNA as a potential biomarker for regulating the osteogenic differentiation process

Liu

Zheng

et al. 2022

Mol Biol Rep

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Tissue engineered bone brings hope to the treatment of bone defects, and the osteogenic differentiation of stem cells is the key link. Inducing osteogenic differentiation of stem cells may be a potential approach to promote bone regeneration. In recent years, lncRNA has been studied in the field increasingly, which is believed can regulate cell cycle, proliferation, metastasis, differentiation and immunity, participating in a variety of physiology and pathology processes. At present, it has been confirmed that certain lncRNAs regulate the osteogenesis of stem cells and take part in mediating signaling pathways including Wnt/β-catenin, MAPK, TGF-β/BMP, and Notch pathways. Here, we provided an overview of lncRNA, reviewed its researches in the osteogenic differentiation of stem cells, emphasized the importance of lncRNA in bone regeneration, and focused on the roles of lncRNA in signaling pathways, in order to make adequate preparations for applying lncRNA to bone tissue Engineering, letting it regulate the osteogenic differentiation of stem cells for bone regeneration.

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“…The extracellular domain, which is the receptor part, is transported to the cell surface and exits the cell by exocytosis, allowing it to bind ligands. There are four variants of NOTCH (NOTCH1-4) and their ligands include five known proteins (JAG1, JAG2, DLL1, DLL3, DLL4) on the adjacent cell surface [ 14 , 15 ]. NOTCH protein is activated by binding to one of these ligands.…”

Section: Notch Signalingmentioning

confidence: 99%

Progress and Current Status in Hajdu-Cheney Syndrome with Focus on Novel Genetic Research

Aida

Ohno

Azuma

2022

IJMS

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Hajdu-Cheney syndrome (HCS) is a rare autosomal dominant manifestation of a congenital genetic disorder caused by a mutation in the NOTCH2 gene. NOTCH signaling has variations from NOTCH 1 to 4 and maintains homeostasis by determining and regulating the proliferation and differentiation of various cells. In HCS, the over-accumulated NOTCH2 causes abnormal bone resorption due to its continuous excessive signaling. HCS is characterized by progressive bone destruction, has complex wide-range clinical manifestations, and significantly impacts the patient’s quality of life. However, no effective treatment has been established for HCS to date. There are genetic variants of NOTCH2 that have been reported in the ClinVar database of the U.S. National Institutes of Health. In total, 26 mutant variants were detected based on the American College of Medical Genetics and Genomics (ACMC). To date, there has been no comprehensive compilation of HCS mutations. In this review, we provide the most comprehensive list possible of HCS variants, nucleotide changes, amino acid definitions, and molecular consequences reported to date, following the ACMC guidelines.

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Enhanced Osteogenic Differentiation of Pluripotent Stem Cells via γ-Secretase Inhibition

Cited by 8 publications

References 80 publications

Multifunctional Self-Assembled Peptide Hydrogels for Biomedical Applications

Multifunctional Self-Assembled Peptide Hydrogels for Biomedical Applications

The management of bone defect using long non-coding RNA as a potential biomarker for regulating the osteogenic differentiation process

Progress and Current Status in Hajdu-Cheney Syndrome with Focus on Novel Genetic Research

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