Enhanced oral bioavailability of a cancer preventive agent (SR13668) by employing polymeric nanoparticles with high drug loading

Shen, Hao; Banerjee, Aryamitra; Mlynarska, Paulina; Hautman, Mathew; Hong, Seungpyo; Kapetanović, Izet M.; Lyubimov, Alexander V.; Liu, Ying

doi:10.1002/jps.23269

Cited by 15 publications

(18 citation statements)

References 38 publications

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“…In the latter case, the advantage of water is associated with the non-toxicity and the reduction of the risk of explosion [1,114]. Furthermore, mixtures of water and suitable water-miscible organic solvents such as ethanol could reduce the final boiling point of the solvent system and enable the spray-drying at lower temperature [74,80,83].…”

Section: Accepted Manuscriptmentioning

confidence: 98%

“…However, when they were analyzed by SEM, individual NPs clustered together were observed, which explained the greater size determined by laser diffraction [57]. To prevent irreversible aggregation phenomena of the NPs after spray-drying, "spacer" excipients such as sucrose, trehalose, and leucine can be used [74]. In addition, in some cases, the small size and the insufficient inertia of the NPs limit their administration.…”

Section: Production Of Nanocomposite Microparticlesmentioning

confidence: 99%

“…[26, 35,101] and PLGA [44,74,82,98,[102][103][104][105][106], or hydrophilic ones such as chitosan [25,45,56,94,[107][108][109][110][111], alginate [37,112], poly(vinylpyrrolidone) (PVP) [113,114], hydroxypropylmethylcellulose (HPMC) [69] and gelatin [50,115] are initially dissolved in organic or aqueous solvents, respectively, and then spray-dried. In the former, the main advantage is the use of solvents with low boiling point.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

See 2 more Smart Citations

Advantages and challenges of the spray-drying technology for the production of pure drug particles and drug-loaded polymeric carriers

Sosnik

Seremeta

2015

Advances in Colloid and Interface Science

501

252

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Section: Accepted Manuscriptmentioning

confidence: 98%

Section: Production Of Nanocomposite Microparticlesmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

See 1 more Smart Citation

Advantages and challenges of the spray-drying technology for the production of pure drug particles and drug-loaded polymeric carriers

Sosnik

Seremeta

2015

Advances in Colloid and Interface Science

501

252

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“…We have developed a continuous and scalable process to reproducibly generate stable nanoparticles with controlled size distribution and high drug loading. 14, 15 The enhanced oral bioavailability of a hydrophobic drug compound was demonstrated in mice and beagle dogs. 14, 16 …”

Section: Introductionmentioning

confidence: 99%

“…14, 15 The enhanced oral bioavailability of a hydrophobic drug compound was demonstrated in mice and beagle dogs. 14, 16 …”

Section: Introductionmentioning

confidence: 99%

Orally Administered Nanocurcumin to Attenuate Morphine Tolerance: Comparison between Negatively Charged PLGA and Partially and Fully PEGylated Nanoparticles

Shen

Szymusiak

et al. 2013

Mol. Pharmaceutics

Self Cite

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We have formulated hydrophobic curcurmin [1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] into stable nanoparticle suspensions (nano-curcumin) to overcome its relatively low bioavailability, high rate of metabolism and rapid elimination and clearance from the body. Employing the curcumin nanoformulations as the platform, we discovered that curcumin has the potential to alleviate morphine tolerance. The two types of stable polymeric nanoparticles - poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol)-b-poly(lactic acid) (PEG-b-PLA) - and the hybrid of the two were generated using flash nanoprecipitation integrated with spray drying. The optimized formulations have high drug loading (>45%), small particles size with narrow distribution, and controlled surface properties. Mice behavioral studies (tail-flick and hot-plate tests) were conducted to verify the effects of nano-curcumin on attenuating morphine tolerance. Significant analgesia was observed in mice during both tail-flick and hot-plate tests using orally administrated nano-curcumin following subcutaneous injections of morphine. However, unformulated curcumin at the same dose showed no effect. Compared with PEGylated nano-curcumin, negatively charged PLGA nanoparticles showed better functionality.

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Oral Nanotherapeutics for Cancer with Innovations in Lipid and Polymeric Nanoformulations

Donovan

Liu

2018

Bioanalysis

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Enhanced oral bioavailability of a cancer preventive agent (SR13668) by employing polymeric nanoparticles with high drug loading

Cited by 15 publications

References 38 publications

Advantages and challenges of the spray-drying technology for the production of pure drug particles and drug-loaded polymeric carriers

Advantages and challenges of the spray-drying technology for the production of pure drug particles and drug-loaded polymeric carriers

Orally Administered Nanocurcumin to Attenuate Morphine Tolerance: Comparison between Negatively Charged PLGA and Partially and Fully PEGylated Nanoparticles

Oral Nanotherapeutics for Cancer with Innovations in Lipid and Polymeric Nanoformulations

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