Enhanced Nuclear Localization of Photosensitizer Using Artificial Oil Bodies for Photodynamic Therapy

Lai, Syu-Ming; Chiou, Yu-Chi; Chen, Guofeng; Liao, Ming-Yuan; Tzen, Jason T.C.; Lai, Ping‐Shan

doi:10.1080/23080477.2016.1255293

Cited by 8 publications

(7 citation statements)

References 24 publications

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“…The absorption spectrum (Figure S1) shows that the NIR-IO nanocrystals absorb light extended to long wavelengths including visible (660 nm) and NIR (808 nm) regions. Band around 660 and 808 nm are commonly used in PTT and photodynamic therapy (PDT) 21, 26, 40. To further evaluate the optical properties of the NIR-IO, the extinction coefficient ε was determined, as listed in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Co-precipitation Synthesis of Near-infrared Iron Oxide Nanocrystals on Magnetically Targeted Imaging and Photothermal Cancer Therapy via Photoablative Protein Denature

Syu¹,

Huang²,

Hsiao³

et al. 2019

Nanotheranostics

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Near-infrared (NIR)-based nanomaterials that provide efficient tumor ablation for cancer therapy have been reported. However, the issues of biocompatibility of metals or ions in inorganic nanoparticles systems such as copper and gold nanoparticles are still a matter of concern. In this study, we developed a facile and ligand-assisted co-precipitation method to synthesize biocompatible iron oxide (IO) nanocrystals with NIR absorption that provided T2-weighted magnetic resonance (MR) images and photothermal ablation characteristics suitable for cancer theranostics. Our results showed that 150-nm particles can be synthesized and optimized by using different amounts of ligand. NIR-IO nanocrystals of this size showed high photothermal conversion efficiency (21.2%) and T2-weighted MR contrast (transverse relaxivity value approximately 141 S-1 mM-1). The NIR-IO nanocrystals showed no cytotoxicity in HT-29 colorectal cancer cells without irradiation, whereas the viability of cells that received NIR-IO nanocrystals decreased significantly after 808-nm laser irradiation. The mechanism of cell death may involve alterations in protein secondary structure and membrane permeability. For in vivo studies, 4-fold enhanced tumor accumulation was significantly observed of NIR-IO nanocrystals with a magnetic field (MF) application, resulting in a 3-fold higher T2-weighted MR signal than that produced by a commercial T2-weighted MR contrast agent (Resovist®) and excellent photothermal efficacy (approximately 53 °C) for cancer treatment. The innovative NIR-IO nanocrystals showed excellent biocompatibility and have great potential as a theranostic agent against cancer.

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Section: Resultsmentioning

confidence: 99%

Co-precipitation Synthesis of Near-infrared Iron Oxide Nanocrystals on Magnetically Targeted Imaging and Photothermal Cancer Therapy via Photoablative Protein Denature

Syu¹,

Huang²,

Hsiao³

et al. 2019

Nanotheranostics

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“…[1][2][3][4] For this purpose, several photosensitizers, such as Photofrin, 5-aminolevulinic acid (ALA), Foscan, and Verteporn, have been clinically approved for the treatment of cancersa nd skin diseases with light irradiation. [1][2][3][4] For this purpose, several photosensitizers, such as Photofrin, 5-aminolevulinic acid (ALA), Foscan, and Verteporn, have been clinically approved for the treatment of cancersa nd skin diseases with light irradiation.…”

Section: Introductionmentioning

confidence: 99%

“…Due to the lowers ide effects of photodynamic therapy( PDT) as compared to chemo-and radiotherapies, it has been effectively applied in the development of therapeutic cancert reatment. [1][2][3][4] For this purpose, several photosensitizers, such as Photofrin, 5-aminolevulinic acid (ALA), Foscan, and Verteporn, have been clinically approved for the treatment of cancersa nd skin diseases with light irradiation. [5,6] Recently,t oi mprove the selectivity and efficacy against canceri nP DT treatments, transition metal complexes have been considered.…”

Section: Introductionmentioning

confidence: 99%

Photocytotoxic Copper(II) Complexes with Schiff‐Base Scaffolds for Photodynamic Therapy

Lin

Chiu

Hsu

et al. 2018

Chemistry A European J

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Photodynamic therapy (PDT) is a promising and minimally invasive method for the treatment of superficial diseases, and photosensitizers with high phototoxicity indices (defined as (IC )/(IC )) are essential for the development of ideal photosensitizing properties for this technology. Herein, we report a series of photocytotoxic copper(II) complexes [Cu( QYMP)(dppn)] ( QYMP=N,N,O-tridentate Schiff-base derivatives, dppn=benzo[i]dipyrido[3,2-a;2',3'-c]phenazine), the structures of which have been confirmed by mass spectrometry and FTIR spectroscopy. X-ray crystallography revealed that the CuN O core of the [Cu( QYMP)(dppn)](ClO ) complex (3) has a distorted square-pyramidal geometry. Phototoxicity indices of 329 against human squamous cell carcinoma (SCC15) and 296 against basal cell carcinoma (BCC) cell lines have been determined with [Cu( QYMP)(dppn)](ClO ) (4). This can be attributed to the formation of reactive oxygen species, cell apoptosis, and caspase-3 activation, indicating high potential of complex 4 as a photosensitizer candidate in PDT. Thus, copper complexes bearing suitable Schiff-base ligands with a dppn co-ligand may be considered for the design of efficient metal-based anticancer agents for PDT.

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“…PDT is a photochemical process which is used to generate localized cell death, and involves the activation of a photosensitizing drug in the target area with light in the presence of molecular oxygen [ 32 ]. Our group has reported several PDT-related studies for cancer therapy, including the photo-triggered drug/gene release and nanoparticle-based photosensitizer delivery systems [ 33 , 34 , 35 , 36 , 37 ]. PDT is not only a therapy for cancer and other diseases but is also an antimicrobial strategy [ 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Photo-Crosslinked Polymeric Matrix with Antimicrobial Functions for Excisional Wound Healing in Mice

et al. 2018

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Wound infection extends the duration of wound healing and also causes systemic infections such as sepsis, and, in severe cases, may lead to death. Early prevention of wound infection and its appropriate treatment are important. A photoreactive modified gelatin (GE-BTHE) was synthesized by gelatin and a conjugate formed from the 3,3′,4,4′-benzophenone tetracarboxylic dianhydride (BTDA) and the 2-hydroxyethyl methacrylate (HEMA). Herein, we investigated the photocurable polymer solution (GE-BTHE mixture) containing GE-BTHE, poly(ethylene glycol) diacrylate (PEGDA), chitosan, and methylene blue (MB), with antimicrobial functions and photodynamic antimicrobial chemotherapy for wound dressing. This photocurable polymer solution was found to have fast film-forming property attributed to the photochemical reaction between GE-BTHE and PEGDA, as well as the antibacterial activity in vitro attributed to the ingredients of chitosan and MB. Our in vivo results also demonstrated that untreated wounds after 3 days had the same scab level as the GE-BTHE mixture-treated wounds after 20 s of irradiation, which indicates that the irradiated GE-BTHE mixture can be quickly transferred into artificial scabs to protect wounds from an infection that can serve as a convenient excisional wound dressing with antibacterial efficacy. Therefore, it has the potential to treat nonhealing wounds, deep burns, diabetic ulcers and a variety of mucosal wounds.

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Enhanced Nuclear Localization of Photosensitizer Using Artificial Oil Bodies for Photodynamic Therapy

Cited by 8 publications

References 24 publications

Co-precipitation Synthesis of Near-infrared Iron Oxide Nanocrystals on Magnetically Targeted Imaging and Photothermal Cancer Therapy via Photoablative Protein Denature

Co-precipitation Synthesis of Near-infrared Iron Oxide Nanocrystals on Magnetically Targeted Imaging and Photothermal Cancer Therapy via Photoablative Protein Denature

Photocytotoxic Copper(II) Complexes with Schiff‐Base Scaffolds for Photodynamic Therapy

Photo-Crosslinked Polymeric Matrix with Antimicrobial Functions for Excisional Wound Healing in Mice

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