Enhanced neutrophil migration in vivo HLA B27 positive subjects.

Abstract

SUMMARY Chemotaxis of polymorphonuclear leucocytes in vivo was studied in patients with previous yersinia arthritis and in healthy subjects with or without HLA B27 by means of a skin chamber technique. Irrespective of previous arthritis the number of neutrophils in the chamber media was significantly higher in HLA B27 positive subjects than in those without HLA B27. The amounts of prostaglandins E2, F2,af, and 6-keto-Fla in the chamber media correlated positively with the corresponding cell counts. The present results give credence to the view that the hyperreactive neutrophils and the vasodilatory prostaglandins produced by them can together trigger a vicious circle which results in increased inflammatory symptoms in patients with yersinia arthritis who have HLA B27 as compared with those who lack this antigen.

Polymorphonuclear leucocyte function and previous yersinia arthritis: enhanced chemokinetic migration and oxygen radical production correlate with the severity of the acute disease.

“…The mean intervals between the acute phase of YA and the time of the present study were 8-5 years (range [5][6][7][8][9][10][11][12][13][14] in group I and 8-6 years (5-11) in group II. Two patients, one in each group, were studied simultaneously, and the pairs were matched for age and sex (three pairs were matched only for age).…”

“…6 The relevance of these findings to the in vivo conditions has been confirmed by means of a skin chamber technique. 7 To see whether a correlation can be found between enhanced PMN responsiveness and the severity of YA we compared PMN functions in two Accepted for publication 22 September 1986. Correspondence to Dr Paivi Koivuranta-Vaara, Department of Bacteriology and Immunology, University of Helsinki, Haartmaninkatu 3, SF-00290 Helsinki, Finland.…”

Neutrophil Chemotaxis in Patients with Pustulotic Arthro-Osteitis

“…The in vivo PMN chemotaxis is dependent on both the cells and the presence or absence of chemotaxis-enhancing serum factors. The presence of hyperactive neutrophils may trigger a vicious circle of inflammation [33][34][35], Such a circle can explain the prolonged course in the present patients with progressive sternocosto-clavicular dis ease, who had a higher level of PMN chemotaxis, than the patients with station ary or regressive changes.…”

T lymphocytes in ankylosing spondylitis and the influence of sulphasalazine treatment

“…The neutrophil granulocyte has by several authors been considered as hyperreactive in the inflammatory diseases affecting HLA B27 positive subjects. Not only in patients with AS and reactive arthritis but also in their HLA B27 positive firstdegree relatives have neutrophils with enhanced function been found (29,30). We have recently presented data showing activation of yet another granulocytic cell, the eosinophil (31).…”