Enhanced muscle insulin receptor autophosphorylation with short-term aerobic exercise training

Youngren, Jack; Keen, Stephanie; Kulp, Jennifer L.; Tanner, Charles J.; Houmard, Joseph A.; Goldfine, Ira D.

doi:10.1152/ajpendo.2001.280.3.e528

Cited by 44 publications

(36 citation statements)

References 39 publications

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“…Finally, the results of the present study regarding HO-MA-IR showed that weight loss resulted in decrease in HOMA-IR, this result confirmed by Younger and colleagues reported that increased physical activity leads to improvement in insulin resistance and increase in muscle oxidative capacity which are likely contribute to the beneficial effects of exercise training on insulin action 49 . Also, Kriska and colleagues confirmed that physical activity in obese non-insulin dependent diabetes mellitus decreased blood glucose level through improving insulin sensitivity and decreasing deposition of total fat and intra-abdominal fat.…”

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confidence: 89%

Psychological wellbeing and biochemical modulation in response to weight loss in obese type 2 diabetes patients

Osama¹,

Shehab²

2015

Afr H. Sci.

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Background: Obesity in type 2 diabetes patients is a serious health issue by itself; it is also associated with other health problems including psychiatric illnesses. The psychological effects of dieting and weight loss have been a matter of controversy in the field of obesity management. Objective: The aim of this study was to compare the impact of weight loss because of aerobic exercise training and dietary measures on psychological wellbeing and biochemical modulation in obese type 2 diabetes patients. Material and methods: One hundred obese type 2 diabetes patients of both sexes participated in this study, and were included into two equal groups. The first group (A) received aerobic exercise training, three sessions per week for three months combined with dietary measures. The second group (B) received no training intervention for three months. Results: There was a significant decrease in body mass index (BMI), leptin, total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), triglycerides(TG), homeostasis model assessment-insulin resistance-index (HOMA-IR) , beck depression inventory (BDI ) & profile of mood states(POMS) and increase in high density lipoprotein cholesterol (HDL-c) & Rosenberg self-esteem scale (RSES) of group (A) after treatments, but the changes of group (B) were not significant. Moreover, there were significant differences between mean levels of the investigated parameters of group (B) and group (A) at the end of the study. Conclusion: Physical training and dietary measures can be used as methods of choice for psychological wellbeing and biochemical modulation in obese type 2 diabetes patients.

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confidence: 89%

Psychological wellbeing and biochemical modulation in response to weight loss in obese type 2 diabetes patients

Osama¹,

Shehab²

2015

Afr H. Sci.

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“…[8][9][10] In earlier studies, we have demonstrated that insulin-stimulated IR autophosphorylation is improved in muscle from subjects following a 7-day exercise training program. 31 Conversely, we have shown that high-fat feeding in rats can induce impairments in IR autophosphorylation within 2 weeks, which is before the acquisition of increased fat stores occurs. 32 In this study, we found increases in IR autophosphorylation following bariatric surgery in the four subjects with the lowest pre-surgery IR autophosphorylation.…”

Section: Discussionmentioning

confidence: 86%

Muscle insulin receptor concentrations in obese patients post bariatric surgery: relationship to hyperinsulinemia

et al. 2004

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OBJECTIVE:Obesity results in insulin resistance. Bariatric surgery for obese individuals induces weight loss, improves insulin sensitivity, and lowers insulin levels. We investigated the mechanisms of this improvement. DESIGN: Insulin receptor (IR) content, IR signaling, and adiponectin levels were measured in nine morbidly obese subjects before and after bariatric surgery. SUBJECTS: Seven female and two male, average age 4472y, BMI 440 kg/m 2 and/or at least 100 lbs over ideal body weight, undergoing elective bariatric surgery. MEASUREMENTS: Before surgery BMI, fasting plasma glucose, adiponectin, and insulin levels were measured. A fasting muscle biopsy was obtained from the vastus lateralis for IR concentration and autophosphorylation activity measurements. These procedures were repeated 1 y after surgery. RESULTS: At 1 y after surgery, the subjects had lost an average of 48.375.6 kg (Po0.001), insulin sensitivity had significantly increased as determined by the minimal model (SI 0.7270.18 vs 3.8671.43, Po0.05), and IR content had increased two-fold in muscle (2.170.4 vs 4.370.7 ng/mg protein, Po0.01). The increase in IR content was related to fasting insulin levels. In the subjects with the lowest IR function, there was also an increase in IR function. Plasma adiponectin increased by 40% following weight loss (7.471.6 pre vs 10.371.3 mg/ml post, Po0.05). There was no significant change in muscle content of the IR inhibitor, PC-1. CONCLUSION: Increased IR content, most likely regulated by insulin levels, may be one contributor to the increased insulin sensitivity that occurs when morbidly obese patients undergo bariatric surgery.

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“…Here we report that exercise training in Type 2 diabetic individuals resulted in a "normalization" of TG m content, but did not completely reverse insulin resistance in these patients. It is well known that endurance training improves insulin action in healthy individuals [9], with an increase in insulin sensitivity being observed after only 7 days of training [18,19,20]. The mechanisms by which exercise training improves insulin action in healthy skeletal muscle have been attributed to increases in insulin-stimulated PI3-kinase activity [18], increased expression of GLUT4 [21], hexokinase [22] and glycogen synthase [22].…”

Section: Discussionmentioning

confidence: 99%

Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes

et al. 2004

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Aim/hypothesis. We determined the effect of exercise training on insulin sensitivity and muscle lipids (triglyceride [TG m ] and long-chain fatty acyl CoA [LCACoA] concentration) in patients with Type 2 diabetes. Methods. Seven patients with Type 2 diabetes and six healthy control subjects who were matched for age, BMI, % body fat and VO 2 peak participated in a 3 days per week training program for 8 weeks. Insulin sensitivity was determined pre-and post-training during a 120 min euglycaemic-hyperinsulinaemic clamp and muscle biopsies were obtained before and after each clamp. Oxidative enzyme activities [citrate synthase (CS), β-hydroxy-acyl-CoA (β-HAD)] and TG m were determined from basal muscle samples pre-and post training, while total LCACoA content was measured in samples obtained before and after insulinstimulation, pre-and post training. Results. The training-induced increase in VO 2 peak (~20%, p<0.01) was similar in both groups. Compared with control subjects, insulin sensitivity was lower in the diabetic patients before and after training (~60%; p<0.05), but was increased to the same extent in both groups with training (~30%; p<0.01). TG m was increased in patients with Type 2 diabetes (170%; p<0.05) before, but was normalized to levels observed in control subjects after training. Basal LCACoA content was similar between groups and was unaltered by training. Insulin-stimulation had no detectable effect on LCACoA content. CS and β-HAD activity were increased to the same extent in both groups in response to training (p<0.001). Conclusion/interpretation. We conclude that the enhanced insulin sensitivity observed after short-term exercise training was associated with a marked decrease in TG m content in patients with Type 2 diabetes. However, despite the normalization of TG m to levels observed in healthy individuals, insulin resistance was not completely reversed in the diabetic patients. Type 2 diabetes is characterized by skeletal muscle insulin resistance and impaired glucose metabolism. In addition to disturbances in glucose homeostasis, individuals with Type 2 diabetes have an impaired lipid metabolism, reflected by increased circulating free fatty acids [1], reduced rates of whole body fat oxidation [2] and excessive deposition of lipids in various tissues including skeletal muscle [3]. With regard to muscle lipid status, there is evidence in humans that increased trigacylglycerol (TG m ) concentration [3,4,5,6,7] and increased long-chain fatty acyl CoA (LCACoA) content are negatively associated with whole body insulin action [8]. Considering the rela-

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Enhanced muscle insulin receptor autophosphorylation with short-term aerobic exercise training

Cited by 44 publications

References 39 publications

Psychological wellbeing and biochemical modulation in response to weight loss in obese type 2 diabetes patients

Psychological wellbeing and biochemical modulation in response to weight loss in obese type 2 diabetes patients

Muscle insulin receptor concentrations in obese patients post bariatric surgery: relationship to hyperinsulinemia

Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes

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