Enhanced Liver Fibrosis Panel as a Predictor of Liver Fibrosis in Chronic Hepatitis C Patients

Fernandes, Flávia; Ferraz, M.L.G.; Andrade, Luiz Eduardo Coelho; Dellavance, Alessandra; Terra, Carlos; Pereira, João Luiz; Campos, Frederico; Figueiredo, Fábio P.; Perez, Renata M.

doi:10.1097/mcg.0000000000000128

Cited by 37 publications

(47 citation statements)

References 45 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ELF test measures three direct markers of liver matrix metabolism in serum: hyaluronic acid (HA), tissue inhibitor of metalloproteinase-1 (TIMP-1) and propeptide of type III procollagen (PIIINP), which are combined to calculate the ELF score. The ELF score was validated for liver fibrosis assessment in a large group of patients with various CLDs (5) and has also been confirmed in specific patient cohorts (4,(6)(7)(8)(9)(10)(11). More recent studies suggest that ELF score is influenced by age, gender and liver inflammatory activity, and that these factors may confound diagnosis at earlier fibrosis stages (12,13).…”

Section: See Editorial On Page 1643mentioning

confidence: 87%

ELF score ≥9.8 indicates advanced hepatic fibrosis and is influenced by age, steatosis and histological activity

Fagan

Pretorius

Horsfall

et al. 2015

Liver International

View full text Add to dashboard Cite

show abstract

Section: See Editorial On Page 1643mentioning

confidence: 87%

ELF score ≥9.8 indicates advanced hepatic fibrosis and is influenced by age, steatosis and histological activity

Fagan

Pretorius

Horsfall

et al. 2015

Liver International

View full text Add to dashboard Cite

show abstract

“…In spite the initial outstanding performance of recently defined index, enhanced liver fibrosis (ELF), which combines several variables (hyaluronic acid, tissue inhibitor of matrix metalloproteinases-1, and amino-terminal propeptide of type III procollagen[41], the limited sample size of cirrhotic patients in that cohort ( n = 29) could lead to overestimate its diagnostic potential[42]. Indeed, angiopoietins ratio displays better AUC-ROCs for cirrhosis identification when ELF is analyzed in a larger cohort of patients (0.81 vs 0.78).…”

Section: Discussionmentioning

confidence: 99%

Angiopoietin-2/angiopoietin-1 as non-invasive biomarker of cirrhosis in chronic hepatitis C

Hernández-Bartolomé¹,

López‐Rodríguez²,

Borque³

et al. 2016

WJG

View full text Add to dashboard Cite

AIMTo evaluate the efficacy of peripheral blood concentrations of angiopoietins (Ang) as cirrhosis biomarkers of chronic hepatitis C (CHC).METHODSAng1 and Ang2 serum levels were measured by enzyme-linked immunosorbent assays (ELISA) in samples from 179 cirrhotic and non-cirrhotic CHC patients, classified according to the METAVIR system. Groups were compared by non-parametric Mann-Whitney U test. Subsequently, the association of peripheral concentrations of angiopoietins with the stage of fibrosis was analyzed using Spearman correlation test. Finally, the accuracy, sensitivity and specificity of circulating angiopoietins for cirrhosis diagnosis were determined by the study of the respective area under the curve of receiver operator characteristics (AUC-ROC).RESULTSPeripheral blood concentrations of Ang1 and Ang2 in CHC patients were significantly related to fibrosis. While Ang1 was decreased in cirrhotic subjects compared to non-cirrhotic (P < 0.0001), Ang2 was significantly increased as CHC progressed to the end stage of liver disease (P < 0.0001). Consequently, Ang2/Ang1 ratio was notably amplified and significantly correlated with fibrosis (P < 0.0001). Interestingly, the individual performance of each angiopoietin for the diagnosis of cirrhosis reached notable AUC-ROC values (above 0.7, both), but the Ang2/Ang1 ratio was much better (AUC-ROC = 0.810) and displayed outstanding values of sensitivity (71%), specificity (84%) and accuracy (82.1%) at the optimal cut-off (10.33). Furthermore, Ang2/Ang1 ratio improved the performance of many other previously described biomarkers or scores of liver cirrhosis in CHC.CONCLUSIONAng2/Ang1 ratio might constitute a useful tool for monitoring the progression of chronic liver disease towards cirrhosis and play an important role as therapeutic target.

show abstract

“…This was solved by using HA as part of the ELF score (43,44). The ELF score was higher in a small sample of chronic HCV patients compared to healthy controls, and it was significantly correlated with histological staging in patients with chronic HCV (43)(44)(45). Higher ELF score values were identified in older individuals.…”

Section: Methodsmentioning

confidence: 98%

Hyaluronic acid as a non-invasive biomarker of liver fibrosis

Neuman

Cohen

Nanau

2016

Clinical Biochemistry

View full text Add to dashboard Cite

Enhanced Liver Fibrosis Panel as a Predictor of Liver Fibrosis in Chronic Hepatitis C Patients

Abstract: ELF panel is a good noninvasive fibrosis marker and showed similar results to TE in CHC patients. However, new cutoff points need to be established to improve its performance on patients with CHC.

Cited by 37 publications

References 45 publications

ELF score ≥9.8 indicates advanced hepatic fibrosis and is influenced by age, steatosis and histological activity

ELF score ≥9.8 indicates advanced hepatic fibrosis and is influenced by age, steatosis and histological activity

Angiopoietin-2/angiopoietin-1 as non-invasive biomarker of cirrhosis in chronic hepatitis C

Hyaluronic acid as a non-invasive biomarker of liver fibrosis

Contact Info

Product

Resources

About