Enhanced Learning by Posttrial Injection of H1-but Not H2-Histaminergic Antagonists into the Nucleus Basalis Magnocellularis Region

Privou, Caroline; Li, Jay-Shake; Hasenöhrl, Rüdiger U.; Huston, Joseph P.

doi:10.1006/nlme.1998.3885

Cited by 16 publications

(10 citation statements)

References 78 publications

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“…By contrast, consolidation of contextual fear memory was hampered by similar infusions of thioperamide and clobenpropit (another H 3 receptor inverse agonist) and improved by the H 3 agonist imetit (Passani et al, 2001;Cangioli et al, 2002). Consistent with these results, consolidation of activeavoidance fear memories can be ameliorated by postacquisition infusions of H 1 receptor antagonists or H 3 receptor agonists into the nucleus basalis magnocellularis, a region strongly connected to the amygdala (Privou et al, 1999). As far as we know, the reconsolidation effects of hippocampal infusions of histaminergic drugs have not been examined yet.…”

Section: Discussionmentioning

confidence: 60%

Differential effects of histamine H3 receptor inverse agonist thioperamide, given alone or in combination with the N-methyl-d-aspartate receptor antagonist dizocilpine, on reconsolidation and consolidation of a contextual fear memory in mice

Charlier

Tirelli

2011

Neuroscience

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Abstract-Albeit there is no doubt that histamine and its H 3 receptors participate in several aspects of learning and memory, such as memory consolidation, nothing is known about their potential involvement in memory reconsolidation. On the basis of previous reports of pro-cognitive effects of histamine H 3 receptor inverse agonists (which augment histamine release), we investigated to what extent the most representative of them, thioperamide, is able to facilitate reconsolidation of a contextually-conditioned fear memory in C57BL/6J mice. We also examined the effects of thioperamide on the stark disruptive effect that the non-competitive N-methyl-D-aspartate (NMDA) antagonist dizocilpine (MK-801) typically exerts on both reconsolidation and consolidation. Post-training systemic injections (i.p.) of thioperamide facilitated consolidation at 10 and 20 mg/kg and reversed amnesia induced by an i.p. injection of 0.12 mg/kg dizocilpine at 5, 10 and 20 mg/kg. Importantly, none of the five thioperamide doses (2.5, 5, 10, 20 and 30 mg/kg) given right after reactivation (reexposure to the context in which training took place 48 h earlier) affected reconsolidation, whereas all similarly given doses of dizocilpine (0.03, 0.06 and 0.12 mg/kg) disrupted it more or less equally. By contrast, thioperamide was able to unambiguously reverse the deficit in reconsolidation induced by 0.12 mg/kg dizocilpine at 10 and 20, but not 5 mg/kg. This is the first demonstration of an involvement of the interactive articulation between histamine and NMDA receptors in the mechanisms of memory reconsolidation, which seems to be indifferent to an increase of brain histamine per se. The results suggest a qualitatively different participation of histaminergic signalling in the mechanisms of reconsolidation and consolidation. The precise circuits within which these interactions take place are yet to be identified.

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Section: Discussionmentioning

confidence: 60%

Differential effects of histamine H3 receptor inverse agonist thioperamide, given alone or in combination with the N-methyl-d-aspartate receptor antagonist dizocilpine, on reconsolidation and consolidation of a contextual fear memory in mice

Charlier

Tirelli

2011

Neuroscience

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“…It has been demonstrated that the histaminergic system is largely responsible for cortical activation and cognitive activities during wakefulness [65]; it also constitutes an important wake-promoting system [66] and participates in the complex regulation of sleep stages, feeding, and cognition [35], [45], [67], [68]. Given that the NBM receives substantial histaminergic afferents from the tuberomamillary nucleus [33], [34], [69]–[71], the functional specificity of histamine release during cognitive processes may depend on the brain regions involved and the histaminergic receptor subtypes being bound, as well as on the nature of the cognitive task [72], [73].…”

Section: Discussionmentioning

confidence: 99%

Histaminergic Modulation of Cholinergic Release from the Nucleus Basalis Magnocellularis into Insular Cortex during Taste Aversive Memory Formation

Purón-Sierra

Miranda

2014

PLoS ONE

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The ability of acetylcholine (ACh) to alter specific functional properties of the cortex endows the cholinergic system with an important modulatory role in memory formation. For example, an increase in ACh release occurs during novel stimulus processing, indicating that ACh activity is critical during early stages of memory processing. During novel taste presentation, there is an increase in ACh release in the insular cortex (IC), a major structure for taste memory recognition. There is extensive evidence implicating the cholinergic efferents of the nucleus basalis magnocellularis (NBM) in cortical activity changes during learning processes, and new evidence suggests that the histaminergic system may interact with the cholinergic system in important ways. However, there is little information as to whether changes in cholinergic activity in the IC are modulated during taste memory formation. Therefore, in the present study, we evaluated the influence of two histamine receptor subtypes, H1 in the NBM and H3 in the IC, on ACh release in the IC during conditioned taste aversion (CTA). Injection of the H3 receptor agonist R-α-methylhistamine (RAMH) into the IC or of the H1 receptor antagonist pyrilamine into the NBM during CTA training impaired subsequent CTA memory, and simultaneously resulted in a reduction of ACh release in the IC. This study demonstrated that basal and cortical cholinergic pathways are finely tuned by histaminergic activity during CTA, since dual actions of histamine receptor subtypes on ACh modulation release each have a significant impact during taste memory formation.

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“…Stimulation of H 1 receptors induces anxiety 62 . On the other hand, injection of an H 1 receptor antagonist (chlorphenamine) reduces anxiety 63,64 . In a previous animal study, it was shown that H 1 receptors facilitate the release of GABA, which in turn inhibits 5‐HT release 65 .…”

Section: Discussionmentioning

confidence: 99%

“…62 On the other hand, injection of an H 1 receptor antagonist (chlorphenamine) reduces anxiety. 63,64 In a previous animal study, it was shown that H 1 receptors facilitate the release of GABA, which in turn inhibits 5-HT release. 65 Therefore, it is suggested that blocking the h: Controls, j: IBS subjects, 0N: neutral, suggestion with 0 mA, 30N: neutral, suggestion with 30 mA.…”

Section: Discussionmentioning

confidence: 99%

Differential responding of autonomic function to histamine H1 antagonism in irritable bowel syndrome

Hattori

Watanabe

Kano

et al. 2010

Neurogastroenterology &Amp; Motility

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Enhanced Learning by Posttrial Injection of H1-but Not H2-Histaminergic Antagonists into the Nucleus Basalis Magnocellularis Region

Cited by 16 publications

References 78 publications

Differential effects of histamine H3 receptor inverse agonist thioperamide, given alone or in combination with the N-methyl-d-aspartate receptor antagonist dizocilpine, on reconsolidation and consolidation of a contextual fear memory in mice

Differential effects of histamine H3 receptor inverse agonist thioperamide, given alone or in combination with the N-methyl-d-aspartate receptor antagonist dizocilpine, on reconsolidation and consolidation of a contextual fear memory in mice

Histaminergic Modulation of Cholinergic Release from the Nucleus Basalis Magnocellularis into Insular Cortex during Taste Aversive Memory Formation

Differential responding of autonomic function to histamine H1 antagonism in irritable bowel syndrome

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