Enhanced laminin adsorption on nanowires compared to flat surfaces

Hammarin, Greger; Persson, Henrik; Dabkowska, Aleksandra P.; Prinz, Christelle

doi:10.1016/j.colsurfb.2014.06.048

Cited by 24 publications

(24 citation statements)

References 35 publications

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“…Experimental studies of Hammarin et al showed that the amount of adsorbed laminin per surface area is up to four times higher on 55 nm diameter gallium phosphide nanowires compared to the flat gallium phosphate surface. [67] Roach et al presented a systematic evaluation of protein response, in terms of conformation, to surface curvature. [51] They showed that a high surface curvature of silica particles with radii less than 30 nm promotes the native-like conformation of globular in shape albumin, in sharp contrast to rod-like fibrinogen, which becomes www.advancedsciencenews.com www.advhealthmat.de denatured to a greater extent.…”

Section: Protein Adsorption Guided By Surface Physicochemical Factorsmentioning

confidence: 99%

Controlling Protein Adsorption through Nanostructured Polymeric Surfaces

Firkowska‐Boden

Zhang

Jandt

2017

Adv Healthcare Materials

105

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The initial host response to healthcare materials' surfaces after implantation is the adsorption of proteins from blood and interstitial fluids. This adsorbed protein layer modulates the biological/cellular responses to healthcare materials. This stresses the significance of the surface protein assembly for the biocompatibility and functionality of biomaterials and necessitates a profound fundamental understanding of the capability to control protein–surface interactions. This review, therefore, addresses this by systematically analyzing and discussing strategies to control protein adsorption on polymeric healthcare materials through the introduction of specific surface nanostructures. Relevant proteins, healthcare materials' surface properties, clinical applications of polymer healthcare materials, fabrication methods for nanostructured polymer surfaces, amorphous, semicrystalline and block copolymers are considered with a special emphasis on the topographical control of protein adsorption. The review shows that nanostructured polymer surfaces are powerful tools to control the amount, orientation, and order of adsorbed protein layers. It also shows that the understanding of the biological responses to such ordered protein adsorption is still in its infancy, yet it has immense potential for future healthcare materials. The review, which is—as far as it is known—the first one discussing protein adsorption on nanostructured polymer surfaces, concludes with highlighting important current research questions.

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Section: Protein Adsorption Guided By Surface Physicochemical Factorsmentioning

confidence: 99%

Controlling Protein Adsorption through Nanostructured Polymeric Surfaces

Firkowska‐Boden

Zhang

Jandt

2017

Adv Healthcare Materials

105

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“…The effects of nanowires on the cell membrane are not well understood either and seem to depend on cell type, nanowire density, interaction time span, and position of the nanowires with respect to the cell 28 29 30 31 . Nanowires have been shown to promote neuronal adhesion and axonal growth 1 17 32 33 34 , which has recently been attributed to an enhanced laminin adsorption on nanowires caused by curvature effects 35 . The presence of nanowires has also been shown to increase the number of cells in the S phase of the cell cycle and to up-regulate focal adhesion formation 36 .…”

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confidence: 99%

From immobilized cells to motile cells on a bed-of-nails: effects of vertical nanowire array density on cell behaviour

Persson

Tegenfeldt

et al. 2015

Sci Rep

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The field of vertical nanowire array-based applications in cell biology is growing rapidly and an increasing number of applications are being explored. These applications almost invariably rely on the physical properties of the nanowire arrays, creating a need for a better understanding of how their physical properties affect cell behaviour. Here, we investigate the effects of nanowire density on cell migration, division and morphology for murine fibroblasts. Our results show that few nanowires are sufficient to immobilize cells, while a high nanowire spatial density enables a ”bed-of-nails” regime, where cells reside on top of the nanowires and are fully motile. The presence of nanowires decreases the cell proliferation rate, even in the “bed-of-nails” regime. We show that the cell morphology strongly depends on the nanowire density. Cells cultured on low (0.1 μm−2) and medium (1 μm−2) density substrates exhibit an increased number of multi-nucleated cells and micronuclei. These were not observed in cells cultured on high nanowire density substrates (4 μm−2). The results offer important guidelines to minimize cell-function perturbations on nanowire arrays. Moreover, these findings offer the possibility to tune cell proliferation and migration independently by adjusting the nanowire density, which may have applications in drug testing.

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“…Gallium phosphide as multimodel nanowire employed for different geometries such as rod and cone photoreceptor, ganglion cells, and bipolar cells [56]. Also, the same structure coated with poly-L-ornithine showed that nanowires have significant potential on morphology, adhesion, and metabolism of cells in comparison to the flat surface [57,58].…”

Section: Structure and Overview Of Nanowiresmentioning

confidence: 99%

Application of Nanowires for Retinal Regeneration

Kharaghani¹,

Tajbakhsh²,

Phan³

et al. 2020

Regenerative Medicine

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Nanowires aim at developing advanced architectures are gaining popularity for damaged neural systems. The retina with a complicated structure is an essential part of our visual nervous system. Any disorder inside retina could lead to blindness due to irregularity in transferring neural signals to the brain. In recent years, the emergence of nanostructures, as well as nanowires, has provided a viable means for enhancing the regeneration of retinal. Nanowires with the ability to sense light and converting it to the electrical signals simulate the extracellular electrical properties, which are the newest nanostructures for the retinal applications. The different structure of nanowires has been examined in vitro, and several others are undergoing in vivo for vision recovery. Among the structures, core-shell nanowires and functionalized nanowires with gold nanoparticles attract the attention for the regeneration of retinal neural systems. Herein, subsequently provide an introduction to the anatomy of the retina, and retinal disorders, the latest progress in the regeneration of retina and vision using nanowires will be reviewed. Also, the different structures, including core-shell and functionalized nanowires with nanoparticles, will be examined. Eventually, the point of view and perspective of applying nanowire in retinal regeneration will be offered.

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Enhanced laminin adsorption on nanowires compared to flat surfaces

Cited by 24 publications

References 35 publications

Controlling Protein Adsorption through Nanostructured Polymeric Surfaces

Controlling Protein Adsorption through Nanostructured Polymeric Surfaces

From immobilized cells to motile cells on a bed-of-nails: effects of vertical nanowire array density on cell behaviour

Application of Nanowires for Retinal Regeneration

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