Enhanced invasion of stromal cells from adenomyosis in a three-dimensional coculture model is augmented by the presence of myocytes from affected uteri

Mehasseb, Mohamed K.; Taylor, Anthony H.; Pringle, James H.; Bell, Steven; Habiba, Marwan

doi:10.1016/j.fertnstert.2010.04.016

Cited by 41 publications

(26 citation statements)

References 20 publications

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“…The identification of differences between myocytes in the OM remote from adenomyosis lesions suggests that these are not a reaction to the presence of ectopic endometrium (18,58). Furthermore, the recent observation that myocytes from adenomyosis enhance stromal cell invasion and the presence of similar peak cluster patterns for secreted proteins when adenomyosis stromal and muscle cells grown in culture are compared with normal stromal and muscle cells, respectively (57), suggests that both stromal and muscle cells have a role and reflect a panuterine abnormality (57). Gene expression profile demonstrated differences between mRNA expression in the IM and the OM in women with adenomyosis and the corresponding layers in unaffected uteri.…”

Section: The Myometriummentioning

confidence: 96%

See 1 more Smart Citation

The pathophysiology of uterine adenomyosis: an update

Benagiano

Habiba

Brosens

2012

Fertility and Sterility

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154

123

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Section: The Myometriummentioning

confidence: 96%

“…At the same time, myocytes from adenomyosis enhance invasion of stromal cells when compared with normal myocytes. This suggests that both the stromal and the myometrial components may have a role in the etiology of adenomyosis (57).…”

Section: The Endometriummentioning

confidence: 98%

The pathophysiology of uterine adenomyosis: an update

Benagiano

Habiba

Brosens

2012

Fertility and Sterility

Self Cite

154

123

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“…Review Hapangama & Bulmer Endometrium in adenomyosis may also display evidence of increased invasiveness; stromal cells from adenomyosis exhibit greater invasiveness compared with normal stromal cells when grown on collagen or in co-culture with myocytes from both normal uteri and those affected by adenomyosis [62,63].…”

Section: Future Science Groupmentioning

confidence: 99%

Pathophysiology of Heavy Menstrual Bleeding

Hapangama

Bulmer

2016

Womens Health (Lond Engl)

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Heavy menstrual bleeding (HMB) is a common gynecological complaint with multiple etiologies and diverse pathophysiological origins. This review discusses HMB with reference to the recently proposed PALM-COEIN classification system for abnormal uterine bleeding, initially describing the endometrial events in normal menstruation followed by discussion of the perturbations of normal endometrial shedding that can result in HMB. Our present understanding of the mechanisms of menstrual bleeding as well as many of the pathological aberrations of HMB is incomplete. Further research into the pathophysiology of HMB is urgently needed, as clear knowledge of the mechanisms of this disorder will provide new therapeutic targets to formulate more effective treatments. Keywords: endometrial cancer • endometrial hyperplasia • heavy menstrual bleeding • leiomyoma/fibroid • polycystic ovarian syndromeIn the developed world an average woman undergoes ∼400 repetitive cycles of monthly menstrual bleeding with shedding of her superficial endometrial functional layer. In as many as 20-30% of women, this bleeding is excessive and is termed heavy menstrual bleeding (HMB) [1]. Apart from the physical symptoms of anemia (fatigue, lethargy and exertional dyspnea), HMB can interfere with normal daily life and may affect the social and emotional well being of women, reducing their productivity in society. HMB commonly presents to primary and secondary healthcare providers, with over 1.5 million women suffering from this problem in England and Wales alone [1]. It is the fourth most common reason for secondary gynecological referrals and each year over 30,000 women in England and Wales undergo surgical treatment for HMB [1]. The annual cost to the National Health Service in 2000 was estimated to be over GB£65 million [2] and with the spiraling cost of healthcare provision, it is clear that the current cost of HMB to women, society and the National Health Service is huge.In this review HMB will be discussed with reference to the recently proposed polyps; adenomyosis; leiomyoma; malignancy and hyperplasia; coagulopathy; ovulatory dysfunction; endometrial; iatrogenic and not yet classified (PALM-COEIN) classification system for abnormal uterine bleeding (AUB), approved by the International Federation of Gynecology and Obstetrics [3]. HMB can present as a chronic disorder of over 12 months duration or as an acute increase in bleeding over a short time period. The age at presentation can range from adolescence to the perimenopausal phase and HMB may occur in the context of either ovulatory or anovulatory cycles. This review will briefly describe the endometrial events in normal menstruation followed by discussion of the perturbations of normal endometrial shedding that can result in HMB. Normal menstruationThe purpose of menstruation is unknown but it is a phenomenon confined mainly to the upper order primates and humans [4], suggesting an associated evolutionary advan- tage. The morphology of human endometrium, relatively greater quantity of menstr...

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“…Moreover, it is also noted that local hyperestrogenism and steroid antagonist may induce adenomyosis. 6 A marked increase of microvessel density has also been reported, which may have a role in the initiation of angiogenesis in adenomyosis.…”

Section: Introductionmentioning

confidence: 96%

MR-guided focused ultrasound for the treatment of adenomyosis: current insights

Chin¹,

Walbridge²,

Quinn³

2015

RRFU

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Adenomyosis is a benign gynecological condition causing significant morbidity among women of reproductive age. The available treatments are currently limited in number and efficacy. While hysterectomy is curative, it is unacceptable to many women, particularly those wishing to conserve their fertility. Magnetic resonance-guided focused ultrasound surgery is a noninvasive treatment method that has been used to effectively treat uterine leiomyomata, but until recently has not been routinely used to treat adenomyosis. This review summarizes the current understanding of adenomyosis and high-intensity focused ultrasound, and the recent research into the safety and efficacy of this technique.

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Enhanced invasion of stromal cells from adenomyosis in a three-dimensional coculture model is augmented by the presence of myocytes from affected uteri

Cited by 41 publications

References 20 publications

The pathophysiology of uterine adenomyosis: an update

The pathophysiology of uterine adenomyosis: an update

Pathophysiology of Heavy Menstrual Bleeding

MR-guided focused ultrasound for the treatment of adenomyosis: current insights

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