Enhanced Intraperitoneal Delivery of Charged, Aerosolized Curcumin Nanoparticles by Electrostatic Precipitation

Castagna, Arianna; Zander, Alexandra J; Sautkin, Iaroslaw; Schneider, Marc; Shegokar, Ranjita; Königsrainer, Alfred; Reymond, Marc A.

doi:10.2217/nnm-2020-0373

Cited by 5 publications

(3 citation statements)

References 34 publications

(52 reference statements)

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“…In addition, the application of PIPAC rather than ePIPAC may require using different particles or their specific optimization. Positively charged curcumin loaded PLGA nanoparticles showed a better tissue penetration profile when associated with ePIPAC than a similar negatively charged PLGA formulation or PIPAC performed without an electrostatic field ( 242 ).…”

Section: Exploring Innovative Drug Delivery Formulations As Therapeut...mentioning

confidence: 99%

Localized chemotherapy approaches and advanced drug delivery strategies: a step forward in the treatment of peritoneal carcinomatosis from ovarian cancer

et al. 2023

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Peritoneal carcinomatosis (PC) is a common outcome of epithelial ovarian carcinoma and is the leading cause of death for these patients. Tumor location, extent, peculiarities of the microenvironment, and the development of drug resistance are the main challenges that need to be addressed to improve therapeutic outcome. The development of new procedures such as HIPEC (Hyperthermic Intraperitoneal Chemotherapy) and PIPAC (Pressurized Intraperitoneal Aerosol Chemotherapy) have enabled locoregional delivery of chemotherapeutics, while the increasingly efficient design and development of advanced drug delivery micro and nanosystems are helping to promote tumor targeting and penetration and to reduce the side effects associated with systemic chemotherapy administration. The possibility of combining drug-loaded carriers with delivery via HIPEC and PIPAC represents a powerful tool to improve treatment efficacy, and this possibility has recently begun to be explored. This review will discuss the latest advances in the treatment of PC derived from ovarian cancer, with a focus on the potential of PIPAC and nanoparticles in terms of their application to develop new therapeutic strategies and future prospects.

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Section: Exploring Innovative Drug Delivery Formulations As Therapeut...mentioning

confidence: 99%

Localized chemotherapy approaches and advanced drug delivery strategies: a step forward in the treatment of peritoneal carcinomatosis from ovarian cancer

et al. 2023

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“…Worldwide, several centers have developed tools for the preclinical study of intraperitoneal aerosolized drug delivery. These include computational models, in vitro models, isolated organ models such as the inverted bladder, and animal models (mouse, rat, pig, sheep) [40][41][42][43][44][45][46][47][48][49][50][51][52].…”

Section: Translational Research and Future Perspectivesmentioning

confidence: 99%

Is PIPAC a Treatment Option in Upper and Lower Gastrointestinal Cancer with Peritoneal Metastasis?

et al. 2022

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Background: The survival prognosis of patients with peritoneal metastasis (PM) of gastrointestinal (GI) cancer is generally poor and treatment consists of, according to international guidelines, systemic chemotherapy. A multimodal treatment approach, including cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy, not only proved to be beneficial mainly in colorectal cancer, but also in selected patients with gastric cancer. The authors performed systematic research of articles and ongoing clinical trials using the keywords “PIPAC” and “gastric cancer” or “colorectal cancer” in PubMed in October 2021. Key findings, such as complications rates, treatment protocols, and overall survival were summarized and illustrated in Tables and critically discussed. Summary: Twenty years ago, the technique of Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) was developed by Reymond et al. and delivered evidence to be recognized as a basic therapeutic tool in this multimodal therapy. Currently, there are several ongoing Phase II and III trials exploring the usage and efficacy of PIPAC as a neoadjuvant, adjuvant, or palliative component of treatment in patients with PM of GI cancer. Key Messages: The aim of this narrative review was to help navigate the reader throughout the most current evidence for the use PIPAC and to highlight its indication in patients with upper and lower GI cancer with PM. It also provides an outline of ongoing studies and future perspectives.

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“…Uncharged NPs tend to bind with serum proteins and, when incubated with cells, their uptake is mediated by specific receptors [ 25 , 26 ]. In general, positively charged NPs are taken up by endocytosis much more often than negatively charged ones because of the presence of phospholipidic molecules [ 27 , 28 , 29 ]. In addition, NPs can be bound to bioconjugates, specific biological molecules recognized by cells receptors [ 30 ].…”

Section: Introduction To Nanoparticlesmentioning

confidence: 99%

The Impact of Metal Nanoparticles on Female Reproductive System: Risks and Opportunities

Aloisi

Rossi

Colafarina

et al. 2022

IJERPH

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Humans have always been exposed to tiny particles via dust storms, volcanic ash, and other natural processes, and our bodily systems are well adapted to protect us from these potentially harmful external agents. However, technological advancement has dramatically increased the production of nanometer-sized particles or nanoparticles (NPs), and many epidemiological studies have confirmed a correlation between NP exposure and the onset of cardiovascular diseases and various cancers. Among the adverse effects on human health, in recent years, potential hazards of nanomaterials on female reproductive organs have received increasing concern. Several animal and human studies have shown that NPs can translocate to the ovary, uterus, and placenta, thus negatively impacting female reproductive potential and fetal health. However, NPs are increasingly being used for therapeutic purposes as tools capable of modifying the natural history of degenerative diseases. Here we briefly summarize the toxic effects of few but widely diffused NPs on female fertility and also the use of nanotechnologies as a new molecular approach for either specific pathological conditions, such as ovarian cancer and infertility, or the cryopreservation of gametes and embryos.

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Enhanced Intraperitoneal Delivery of Charged, Aerosolized Curcumin Nanoparticles by Electrostatic Precipitation

Cited by 5 publications

References 34 publications

Localized chemotherapy approaches and advanced drug delivery strategies: a step forward in the treatment of peritoneal carcinomatosis from ovarian cancer

Localized chemotherapy approaches and advanced drug delivery strategies: a step forward in the treatment of peritoneal carcinomatosis from ovarian cancer

Is PIPAC a Treatment Option in Upper and Lower Gastrointestinal Cancer with Peritoneal Metastasis?

The Impact of Metal Nanoparticles on Female Reproductive System: Risks and Opportunities

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