Enhanced intraarticular free radical reactions in adjuvant arthritis rats

Yamada, Ken Ichi; Nakamura, Toshio; Utsumi, Hideo

doi:10.1080/10715760500440536

Cited by 23 publications

(8 citation statements)

References 29 publications

(34 reference statements)

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“…The mouse eye was located in the space bounded by a coil. We previously confirmed that the signal decay rates of carbamoyl-PROXYL varied at different regions, and the enhancement of signal decay limited to the region exposed to oxidative stress, although details are unclear (25)(26)(27)(28). For example, in adjuvant arthritis model rats, any difference was not observed in the signal-decay rate between arthritis model and control group at the breast and abdomen, although significant enhancement was observed at the paw (27).…”

Section: Conclusion and Open Questionssupporting

confidence: 66%

Are Free Radical Reactions Increased in the Diabetic Eye?

Yamato

Matsumoto

Ura

et al. 2007

Antioxidants & Redox Signaling

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Reactive oxygen species (ROS) are thought to play a significant role in the development of diabetic retinopathy; however, no direct evidence supports ROS generation in vivo. This study used in vivo electron spin resonance (ESR) spectroscopy with a surface resonator to detect local free radical reactions. The ESR signal decay of carbamoyl-PROXYL was enhanced in the eyes of streptozotocin (STZ)-induced diabetic mice. This enhanced signal decay was suppressed by the administration of SOD or the pretreatment with aminoguanidine. We demonstrate, for the first time, specific free radical reactions in the eyes of mice with STZ-induced diabetes.

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Section: Conclusion and Open Questionssupporting

confidence: 66%

Are Free Radical Reactions Increased in the Diabetic Eye?

Yamato

Matsumoto

Ura

et al. 2007

Antioxidants & Redox Signaling

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“…In view of the pleiotropy exhibited by statins and their anti-inflammatory property, the present study was carried out to evaluate the effect of atorvastatin on the levels of oxidative stress markers in the rat model of FCA-induced monoarthritis. The acute inflammatory response elicited by the intra-articular injection of FCA is associated with infiltration of leukocytes, activation of mast cells, release of cytokines and free radicals (Yamada et al 2006;Hershko and Rivera 2010). In the present study FCA produced maximum joint inflammation on day 3 that was associated with increase in oxidative stress, lipid peroxidation and influx of neutrophils as revealed by histological analysis of the joint (Figs.…”

Section: Discussionmentioning

confidence: 89%

Atorvastatin exhibits anti-inflammatory and anti-oxidant properties in adjuvant-induced monoarthritis

2010

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Arthritis is a joint disorder where the joint damage is associated with elevated levels of inflammatory mediators and reactive oxygen species (ROS). The inflammatory hyperalgesia associated with arthritis has been shown to be attenuated by anti-hyperlipidemic drug, atorvastatin. The present study was carried out to evaluate the effect of atorvastatin on joint inflammation and associated oxidative stress markers in a rat model where arthritis was induced by intra-articular injection of 0.1 ml of 0.1% Freund's Complete Adjuvant (FCA). Atorvastatin (10 mg and 50 mg/kg) and diclofenac (5 mg/kg) were administered orally, daily during the study period of 4 days and their effect on joint inflammation was evaluated by measuring joint diameter, levels of glutathione (GSH), thiobarbituric acid reactive substances (TBARS), activity of super oxide dismutase (SOD) and tissue histology. Atorvastatin produced a dose-dependent reduction in joint inflammation that was associated with normalization of levels of oxidative stress markers and tissue histology and its effect was found to be comparable to that of diclofenac.

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“…Intra-articular injection of FCA is known to induce inflammation as well as immune response and to produce features that resemble rheumatoid arthritis in humans. The acute inflammatory response induced by FCA is associated with leukocyte infiltration, mast cell activation, and release of cytokines and free radicals [5, 6]. This process gets aggravated with macrophage activation and secretion of bioactive products that play an important role in tissue destruction, vascular proliferation, and fibrosis over a period of time [7].…”

Section: Introductionmentioning

confidence: 99%

Calotropis procera Latex Extract Affords Protection against Inflammation and Oxidative Stress in Freund's Complete Adjuvant-Induced Monoarthritis in Rats

Kumar

Roy

2007

Mediators of Inflammation

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In view of the well-established anti-inflammatory properties of latex of Calotropis procera (DL), the present study was carried out to evaluate the protective effect of its methanol extract (MeDL) against inflammation and oxidative stress in monoarthritis induced by Freund's complete adjuvant (FCA) in rats. Intra-articular injection of FCA produced inflammation of the joint with a peak effect occurring on day 4 where a maximum increase in the levels of myeloperoxidase and inflammatory mediators like PGE2, TNF-α, and nitric oxide was observed. This was associated with oxidative stress with a marked reduction in the levels of glutathione, catalase, superoxide dismutase and glutathione peroxidase and an increase in the lipid peroxidation as indicated by the higher levels of thiobarbituric acid reactive substances (TBARSs). Subsequently on day 28 the histological analysis of the joint also revealed arthritic changes. Daily treatment of rats with MeDL (50 and 500 mg/kg) and standard anti-inflammatory drug rofecoxib (20 and 100 mg/kg), produced a significant attenuation in the inflammatory response and ameliorated the arthritic changes in the joint. The protection afforded by MeDL and rofecoxib was more pronounced than that of phenylbutazone and was associated with normalization of the levels of inflammatory mediators and biochemical parameters of oxidative stress. However, the overall protection afforded by rofecoxib was better than that of MeDL.

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Enhanced intraarticular free radical reactions in adjuvant arthritis rats

Cited by 23 publications

References 29 publications

Are Free Radical Reactions Increased in the Diabetic Eye?

Are Free Radical Reactions Increased in the Diabetic Eye?

Atorvastatin exhibits anti-inflammatory and anti-oxidant properties in adjuvant-induced monoarthritis

Calotropis procera Latex Extract Affords Protection against Inflammation and Oxidative Stress in Freund's Complete Adjuvant-Induced Monoarthritis in Rats

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