Enhanced interfacial adhesion and osseointegration of anodic TiO2 nanotube arrays on ultra-fine-grained titanium and underlying mechanisms

Hu, Nan; Wu, Yuzheng; Xie, Lizhi; Yusuf, Shahir Mohd; Gao, Nong; Starink, M.J.; Tong, Liping; Chu, Paul K.; Wang, Huaiyu

doi:10.1016/j.actbio.2020.02.009

Cited by 36 publications

(18 citation statements)

References 80 publications

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“…In this research, it has been shown that TiO 2 NTs with length of 0.4 µm, because of less interfacial stress, have high adhesion strength as compared to the longer NTs with length of 2 µm. 94 Employing an innovative method, Alves et al managed to fabricate a collection of 50-90 nm diameter TiO 2 NTs, which simulated the morphology of micron structure of natural bone, and filled them with bioactive elements (calcium and phosphorous) to construct a more efficient bio-functional implant surface. The results demonstrated an enhancement in osteoblastic cell function and adhesion at the interface, along with displaying an improved corrosion behavior for TiO 2 NTs.…”

Section: Bone Implantsmentioning

confidence: 99%

Biomedical Applications of TiO2 Nanostructures: Recent Advances

Jafari¹,

Mahyad²,

Hashemzadeh³

et al. 2020

IJN

253

116

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Titanium dioxide (TiO 2) nanostructures are one of the most plentiful compounds that have emerged in various fields of technology such as medicine, energy and biosensing. Various TiO 2 nanostructures (nanotubes [NTs] and nanowires) have been employed in photoelectrochemical (PEC) biosensing applications, greatly enhancing the detection of targets. TiO 2 nanostructures, used as reinforced material or coatings for the bare surface of titanium implants, are excellent additive materials to compensate titanium implants deficiencies-like poor surface interaction with surrounding tissues-by providing nanoporous surfaces and hierarchical structures. These nanostructures can also be loaded by diversified drugs-like osteoporosis drugs, anticancer and antibiotics-and used as local drug delivery systems. Furthermore, TiO 2 nanostructures and their derivatives are new emerging antimicrobial agents to overcome human pathogenic microorganisms. However, like all other nanomaterials, toxicity and biocompatibility of TiO 2 nanostructures must be considered. This review highlights recent advances, along with the properties and numerous applications of TiO 2-based nanostructure compounds in nano biosensing, medical implants, drug delivery and antibacterial fields. Moreover, in the present study, some recent advances accomplished on the pharmaceutical applications of TiO 2 nanostructures, as well as its toxicity and biocompatibility, are presented.

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Section: Bone Implantsmentioning

confidence: 99%

Biomedical Applications of TiO2 Nanostructures: Recent Advances

Jafari¹,

Mahyad²,

Hashemzadeh³

et al. 2020

IJN

253

116

View full text Add to dashboard Cite

show abstract

“…[106,107] However, the results of the anodization process, can also be influenced by the microstructure of substrate material. [13,106,108,109] It is well known that the large number of structural defects act as preferred sites for active dissolution. [7,32,110] Thereby, it can be assumed that the anodization of UFG/nano Ti results in the faster formation of nanotubes with differential morphology compared with micro Ti.…”

Section: Electrochemical Anodization-nanotubular Topography With Thermentioning

confidence: 99%

“…To the best knowledge of the authors, the first trials to evaluate the effect of the substrate nanostructure on the nanotubes formation were presented for nano Ti fabricated by HE. [108] This process has also been studied for nano Ti fabricated by commonly used SPD techniques such as HPT [13,106,109] and ECAP. [105] It was found that the grain refinement to the nanoscale had virtually no influence on the nanotube diameter.…”

Section: Electrochemical Anodization-nanotubular Topography With Thermentioning

confidence: 99%

“…[109] While no effect of nanostructure on TNT diameter was observed, most studies claim that anodization of nano Ti results in the formation of a thicker TNT layer than in the case of micro Ti-see Figure 7. [13,108,109] That is associated with a large number of structural defects, which accelerates the formation and growth of TNTs due to their enhanced energy. It should be emphasized that the effect of grain refinement on the anodization process depends on surface topography.…”

Section: Electrochemical Anodization-nanotubular Topography With Thermentioning

confidence: 99%

“…[1,[6][7][8][9][10] While clinical trials have confirmed the successful application of dental implants fabricated from nanocrystalline Ti, [4,9] works are still ongoing to develop strategies aimed at enhancing biological response and antibacterial properties without impacting mechanical properties. [11][12][13][14] In this Review, we describe recent approaches taken to modify the properties of nanocrystalline Ti for biomedical applications. Our study focuses on the following aspects: (i) improving biomedical nano Ti properties through bulk and surface modifications, and (ii) the effect of microstructural changes induced by processing of nano Ti on the results of modifications.…”

mentioning

confidence: 99%

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Nanostructured Bulk Titanium with Enhanced Properties—Strategies and Prospects for Dental Applications

Sotniczuk

Garbacz

2021

Adv Eng Mater

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Society is aging fast. The percentage of people aged above 65 years is forecast to rise from 12.4% (in 2000) to 23% by 2100. [1] The figures for 2030 for Europe and the United States are %20% and 30% respectively. [2] At present, almost 23% of US citizens over 65 are completely edentulous, creating great demand for dental replacements. [3] According to the compound annual growth rate (CAGR) forecast, the global dental market is expected to exceed $8 billion by the end of 2024, up from $4.46 billion in 2016. [1] Moreover, with rising life expectancy, modern implants have to serve much longer without requiring revision surgery. This is challenging, especially in the case of elderly people, who tend to suffer diseases that increase the risk of implant rejection. [2] Thus, advanced healthcare requires constant development in the design and fabrication of dental materials. Currently, commercially pure titanium (CP-Ti) is a leading metallic material in the global dental replacements market. [4] This is mainly due to its biocompatibility and high resistance to corrosion in body fluids. Those properties are governed by the presence of a passive layer on Ti surface, created by its strong tendency to oxidize. [5] Nanostructuring by large plastic deformation techniques is a promising approach to altering Ti properties that are essential for dental applications. [1,[6][7][8][9][10] While clinical trials have confirmed the successful application of dental implants fabricated from nanocrystalline Ti, [4,9] works are still ongoing to develop strategies aimed at enhancing biological response and antibacterial properties without impacting mechanical properties. [11][12][13][14] In this Review, we describe recent approaches taken to modify the properties of nanocrystalline Ti for biomedical applications. Our study focuses on the following aspects: (i) improving biomedical nano Ti properties through bulk and surface modifications, and (ii) the effect of microstructural changes induced by processing of nano Ti on the results of modifications. This analysis is prefaced by a brief description of the effect of nanostructure on Ti mechanical and functional properties.

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Electrochemical Insertion of Zinc Ions into Self‐Organized Titanium Dioxide Nanotube Arrays to Achieve Strong Osseointegration with Titanium Implants

Zhao

Wang

Liu

et al. 2022

Adv Materials Inter

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The construction of titanium dioxide (TiO2) nanotube arrays on the surface of metallic titanium has been demonstrated as a practical approach for improving the biocompatibility of titanium orthopedic implants. However, it remains a challenge to form strong bonds between such TiO2‐based systems and the surrounding bone due to their lack of osseointegration ability. Herein, inspired by the intercalation mechanism of rechargeable batteries, a feasible electrochemical strategy is developed to insert high‐concentration bioactive zinc ions into the lattices of TiO2 nanotube arrays with a controlled release performance and without nanostructure collapse. The zinc ion‐inserted TiO2 nanotube arrays give titanium implants that exhibit excellent osteogenesis properties due to the synergistic effect of the nanotube topography and the release of zinc ions. Using the proposed electrochemical zinc insertion technique, the prepared substrates can trigger the osteogenic differentiation of bone marrow‐derived mesenchymal stem cells (MSCs) in vitro and subsequent implant‐to‐bone osseointegration in vivo. This study establishes a feasible and general electrochemical method to enhance the bioactivity and osseointegration of titanium implants, thereby providing a promising strategy for bone tissue repair.

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Enhanced interfacial adhesion and osseointegration of anodic TiO2 nanotube arrays on ultra-fine-grained titanium and underlying mechanisms

Cited by 36 publications

References 80 publications

<p>Biomedical Applications of TiO<sub>2</sub> Nanostructures: Recent Advances</p>

<p>Biomedical Applications of TiO<sub>2</sub> Nanostructures: Recent Advances</p>

Nanostructured Bulk Titanium with Enhanced Properties—Strategies and Prospects for Dental Applications

Electrochemical Insertion of Zinc Ions into Self‐Organized Titanium Dioxide Nanotube Arrays to Achieve Strong Osseointegration with Titanium Implants

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