Enhanced inhibitory effect from interaction of curcumin with amphotericin B or fluconazole against Candida species

Tsao, Sarah; Yin, Mengya

doi:10.38212/2224-6614.2831

Cited by 11 publications

(8 citation statements)

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“…In four studies, PDT had a 100% reducing effect on C. albicans, C. dubliniensis, and C. tropicalis [27,29,31,32] , but this effect was not complete on C. glabrata [27,29] . Although C. glabrata has more resistance than C. albicans in the clinic [42] , but the present finding could be a bias because in other studies, for C. glabrata the minimum inhibitory concentration of Cur was higher than C. albicans and C. tropicalis [43,44] , and with increasing the concentration of Cur during PDT, its relative resistance may decrease [43,44] . Samples collected in the clinic may be more resistant to PDT than the pre-existing standard Candida spp.…”

Section: Discussioncontrasting

confidence: 57%

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Effectiveness of photodynamic therapy with curcumin against Candida species: A systematic review

Limoodi¹,

Khosraviani²,

Moghaddasi³

et al. 2021

Int. J. Appl. Dent. Sci.

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Introduction:In recent years, photodynamic therapy (PDT) has shown an effective role in controlling fungal infections such as oral candidiasis both in laboratory and clinical settings. Curcumin as a natural photosensitizer has antibacterial as well as antifungal effects. The aim of the present study was to evaluate the anti-Candida spp. effects of PDT by using curcumin. Methods: First, the intended keywords were searched in the four following databases: Google Scholar, PubMed, Scopus and Web of Science. The titles were then merged, and the original eligible articles published by the end of 2020 were scrutinized. Results: Out of 167 merged titles, 12 articles (In-vitro, in-vivo: mice & G. mellonella) met the required criteria and were included in the study. The studied Candida spp. were C. albicans, C. dubliniensis, C. glabrata and C. tropicalis. Concentrations of curcumin used in the studies ranged from 0.005 to 1000 µM. The light sources included LED (440-460 nm), diode laser (405, 532, 650 nm) and Xenon lamp (370-680 nm). The results of all studies showed that PDT reduced the colony count and the level of Candida spp. metabolism significantly. PDT efficacy was dependent on curcumin concentration, Candida spp., energy and wavelength of radiations, and it proved more effective in planktonic environments than biofilm environments. Conclusion: PDT using curcumin in a concentration-dependent manner has a potent lethal effect against some Candida spp. and may be considered as a major or adjuvant treatment for some Candida infections.

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Section: Discussioncontrasting

confidence: 57%

“…than azoles, nystatin and amphotericin B [50,[52][53][54] . Cur in combination with fluconazole and amphotericin B [44,50] reduces the MIC of fluconazole and amphotericin B and enhances their effectiveness [34,44] . Cur also can sensitize fluconazole-resistant C. albicans species [53] which adds to its advantage as a PS.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of photodynamic therapy with curcumin against Candida species: A systematic review

Limoodi¹,

Khosraviani²,

Moghaddasi³

et al. 2021

Int. J. Appl. Dent. Sci.

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“…Studies evaluated the antifungal effect of curcumin in vitro due to its low pharmacokonitics in vivo. All these studies showed that curcumin is effective against a lot of fungi including candida species (33)(34)(35) but in our study we evaluated the topical antifungal effect curcumin in vivo and compare it with the nanosized curcumin. To our knowledge, this is the first study to evaluate the effectiveness of topical nanosized curcumin in the treatment of oral candidiasis in vivo.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Topical Application of Nanocurcumin Suspension in Treatment of Oral Candidal Infection (Experimental Study)

Abdelmonem

Moussa

Aboulela

et al. 2022

Alexandria Dental Journal

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INTRODUCTION:Oral candidiasis is the most common human fungal infection resulting from infection of the oral cavity by yeastlike fungus, candida. Its treatment by available topical or systemic antifungal drugs has several problems including toxicity and the development of drug resistance. Hence recent studies have given much attention to molecules from natural sources. Therefore, curcumin is considered one of the promising natural antifungal drugs. It has antifungal properties, but its poor solubility in aqueous solvents results in poor oral bioavailability. To improve the properties of curcumin, recent trails used nanotechnology. The size of nanoparticles can help them to gain entry into cells increasing its solubility and improving its bioavailability. OBJECTIVES: To evaluate the use of topical application of nanocurcumin in treatment of oral candidiasis and compare it to curcumin and nystatin in a murine model. MATERIALS AND METHODS: Thirty-nine female mice were randomly divided into three groups of 13 animals each after induction of oral candidiasis. Group 1 received nanocurcumin at 64 µg/ml. Group 2 received curcumin at 128 µg/ml. Group 3 received nystatin 100000 U/ml. All animals were received treatment topically twice daily for 10 days. The clinical evaluation and microbiological analysis were at baseline, day 5 and day 10. RESULTS: There was no statistical differences between the three studied groups in the number of cured animals at the end of the treatment period (p=0.358). CONCLUSION: Nanocurcumin has a good antifungal effect but further research is needed to get the maximum benefits of these nanoparticles.

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“…También, Khan et al (2012), reportaron la actividad antifúngica de la curcumina frente a 38 cepas de Candida (3 cepas ATCC sensibles al fluconazol, 24 cepas clínicas sensibles al fluconazol y 11 cepas clínicas resistentes al fluconazol) con una CMI90 de curcumina entre 250 y 650 μg/ml para cepas sensibles y entre 250 y 500 μg/ml para cepas resistentes. En otro estudio, la curcumina demostró actividad antifúngica mayor a la observada en este proyecto, con un valor de CMI de 32 µg/ml para C. albicans, además, reportan que la combinación de curcumina con anfotericina B mostró una actividad sinérgica contra especies de Candida (Tsao & Yin, 2000).…”

Section: Discussionunclassified

Efecto antimicrobiano de curcumina sobre Enterococcus faecalis, Escherichia coli, Staphylococcus aureus y Candida albicans

Solano

Aguirre

Vargas

et al. 2020

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Introduction: Due to the development of resistance of microorganisms to multiple drugs, exhaustive investigations of therapeutic agents derived from natural sources, such as curcumin, have been carried out. Curcumin (diferuloylmethane) is a phenolic compound, the main curcuminoid present in the species Curcuma longa L. By virtue of its multiple pharmacological properties (antibacterial, antifungal and anti-inflammatory) it has been of great interest to scientists in recent years. The objective of this study was to evaluate the antimicrobial effect of curcumin through the minimum inhibitory concentration (MIC) on strains of Enterococcus faecalis, Escherichia coli, Staphylococcus aureus and Candida albicans.Method: The in vitro antibacterial activity of curcumin against E. faecalis (ATCC 51299), E. coli (ATCC 25922) and S. aureus (ATCC 25923) was evaluated, following the protocol according to the recommendations of the Clinical and Laboratory Standards Institute (CLSI) in the document M-07-A8. The in vitro antifungal activity of curcumin against C. albicans (ATCC 26790) was evaluated following the protocol according to the CLSI recommendations in the documents M27-A.Results: The MIC values of curcumin were 125 μg/ml, 31.2 μg/ml, 31.2 μg/ml and 125 μg/ml for E. faecalis, E. coli, S. aureus and C. albicans, respectively.Conclusion: The results of this study reveal that curcumin in low concentrations has an antibacterial and antifungal effect on strains of E. faecalis, E. coli, S. aureus and C. albicans.

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Enhanced inhibitory effect from interaction of curcumin with amphotericin B or fluconazole against Candida species

Cited by 11 publications

References 0 publications

Effectiveness of photodynamic therapy with curcumin against Candida species: A systematic review

Effectiveness of photodynamic therapy with curcumin against Candida species: A systematic review

Evaluation of Topical Application of Nanocurcumin Suspension in Treatment of Oral Candidal Infection (Experimental Study)

Efecto antimicrobiano de curcumina sobre Enterococcus faecalis, Escherichia coli, Staphylococcus aureus y Candida albicans

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