Enhanced in vivo lipid peroxidation in scleroderma spectrum disorders

Cracowski, Jean‐Luc; Marpeau, Claudine; Carpentier, Patrick; Imbert, B.; Hunt, Mark J.; Stanke‐Labesque, Françoise; Bessard, Germain

doi:10.1002/1529-0131(200105)44:5<1143::aid-anr196>3.0.co;2-#

Cited by 47 publications

(22 citation statements)

References 41 publications

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“…Measurement of F 2 -IsoPs has implicated a role of free radicals and oxidant injury in a wide variety of human diseases, including cardiovascular, pulmonary, neurological, renal, and liver diseases ( Table 1) [2,5,45]. Although the association between increased oxidative stress and disease does not necessarily imply a causative link, the fact that the increase in F 2 -IsoP levels is an early event in asthma [71,72], hepatic cirrosis [73], scleroderma [74], and Alzheimer's disease [75,76] suggests a causative role for oxidative stress at least in these diseases. Chronic healthy smokers have higher free and esterified F 2 -IsoP plasma concentrations and urinary excretion of F 2 -IsoP metabolites compared to healthy non-smokers, indicating pro-oxidant effects of smoking in vivo [42,77].…”

Section: Isoprostanes As Biomarkers Of Oxidative Stress In Human Disementioning

confidence: 99%

Insights into Oxidative Stress: The Isoprostanes

Montuschi¹,

Barnes²,

Roberts

2007

CMC

215

141

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Oxidative stress, characterized by an imbalance between increased exposure to free radicals and antioxidant defenses, is a prominent feature of many acute and chronic diseases and even the normal aging process. However, definitive evidence for this association has often been lacking due to recognized shortcomings with methods previously available to assess oxidant stress status in vivo in humans. Several in vitro markers of oxidative stress are available, but most are of limited value in vivo because thay lack sensitivity and/or specificity or require invasive methods. Isoprostanes (IsoPs) are prostaglandin (PG)-like compounds that are produced in vivo independently of cyclooxygenase enzymes, primarily by free radical-induced peroxidation of arachidonic acid. F(2)-IsoPs are a group of 64 compounds isomeric in structure to cyclooxygenase-derived PGF(2alpha). Other products of the IsoP pathway are also formed in vivo by rearrangement of labile PGH(2)-like IsoP intermediates including E(2)- and D(2)-IsoPs, cyclopentenone-A(2)- and J(2)-IsoPs, and highly reactive acyclic-ketoaldehydes (isoketals). Oxidation of docosahexaenoic acid, an abundant unsaturated fatty acid in the central nervous system, results in the formation of IsoP-like compounds, termed neuroprostanes. Measurement of F(2)-IsoPs is the most reliable approach to assess oxidative stress status in vivo, providing an important tool to explore the role of oxidative stress in the pathogenesis of human disease. Moreover, F(2)-IsoPs and other products of the IsoP pathway exert potent biological actions both via receptor-dependent and independent mechanisms and therefore may be pathophysiological mediators of disease. Measurement of F(2)-IsoPs may provide a uniquely valuable approach to understanding of the clinical pharmacology of antioxidants.

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Section: Isoprostanes As Biomarkers Of Oxidative Stress In Human Disementioning

confidence: 99%

Insights into Oxidative Stress: The Isoprostanes

Montuschi¹,

Barnes²,

Roberts

2007

CMC

215

141

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“…Basu [72] Plasma/synovial fluid Elevated Systemic sclerosis Cracowski [73,74] Urine Elevated Stein [75] Urine Elevated…”

Section: Inflammatory Diseasesmentioning

confidence: 99%

ReviewIsoprostanes: Novel Bioactive Products of Lipid Peroxidation

Basu

2004

Free Radical Research

202

153

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Isoprostanes, are a novel group of prostaglandin-like compounds that are biosynthesised from esterified polyunsaturated fatty acid (PUFA) through a non-enzymatic free radical-catalysed reaction. Several of these compounds possess potent biological activity, as evidenced mainly through their pulmonary and renal vasoconstrictive effects, and have short half-lives. It has been shown that isoprostanes act as full or partial agonists through thromboxane receptors. Both human and experimental studies have indicated associations of isoprostanes and severe inflammatory conditions, ischemia-reperfusion, diabetes and atherosclerosis. Reports have shown that F2-isoprostanes are authentic biomarkers of lipid peroxidation and can be used as potential in vivo indicators of oxidant stress in various clinical conditions, as well as in evaluations of antioxidants or drugs for their free radical-scavenging properties. Higher levels of F2-isoprostanes have been found in the normal human pregnancy compared to non-pregnancy, but their physiological role has not been well studied so far. Since bioactive F2-isoprostanes are continuously formed in various tissues and large amounts of these potent compounds are found unmetabolised in their free acid form in the urine in normal basal conditions with a wide inter-individual variation, their role in the regulation of normal physiological functions could be of further biological interest, but has yet to be disclosed. Their potent biological activity has attracted great attention among scientists, since these compounds are found in humans and animals in both physiological and pathological conditions and can be used as reliable biomarkers of lipid peroxidation.

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“…Moreover, isoprostanes are more than inert markers of oxidative burden: they are proven to induce ROS production (40), to mediate vascular constriction (41, 42), endothelin-1 gene expression (43) and fibroblast proliferation (44) and to impair angiogenesis (45), all of them are well known specific features of SSc. Thus, is not surprising that raised isoprostanes levels have been demonstrated in different organic fluids (46)(47)(48)(49)(50) in SSc and are related to severity and extent of visceral (49) and vascular involvement (49,51). Of interest such an increase of F 2 -isoprostanes seems predominate in the early steps of SSc (50) highlighting the role of OS as a key factor in the induction of disease.…”

Section: Isoprostanes and Sscmentioning

confidence: 99%

Antioxidant effect of Iloprost: current knowledge and therapeutic implications for systemic sclerosis

Erre¹,

Passiu²

2011

Reumatismo

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Systemic sclerosis (SSc) is a dysimmune disorder of connective tissue characterized by disregulation of endothelial function and progressive tissue fibrosis. Although many studies have been carried out the pathogenesis of SSc is an issue still elusive. In a pioneer paper Murrel DF suggested oxidative stress (OS) as the keystone linking altered immune tolerance, endothelial injury and pro-fibrotic phenotype of SSc (1). In the last decade, this intriguing hypothesis has been strengthened by several firm evidences obtained at a cellular and molecular level. OS refers to a condition characterized by an imbalance in prooxidants and antioxidants, which results in damage to macromolecules..

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Enhanced in vivo lipid peroxidation in scleroderma spectrum disorders

Cited by 47 publications

References 41 publications

Insights into Oxidative Stress: The Isoprostanes

Insights into Oxidative Stress: The Isoprostanes

ReviewIsoprostanes: Novel Bioactive Products of Lipid Peroxidation

Antioxidant effect of Iloprost: current knowledge and therapeutic implications for systemic sclerosis

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