Enhanced in vivo biocompatibility of magnesia-contained bioactive glasses

Arepalli, Sampath Kumar; Tripathi, Himanshu; Manna, Partha Pratim; Pankaj, Pankaj; Krishnamurthy, Sairam; Patne, Shashikant C. U.; Pyare, Ram; Singh, Swapnil

doi:10.1007/s41779-018-0239-7

Cited by 2 publications

(2 citation statements)

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“…The coexistence of sodium and magnesium in SNCMP glass has dual importance since it enhanced bioactivity and hindered the crystallisation of the Na2Ca2Si3O9 phase at 600°C, which would be beneficial for sintering at higher temperature. Arepalli et al reported that bioactive glasses in the system (46.10-x)%SiO2-26.9%CaO-24.40%Na2O-xMgO-2.6%P2O5 (where 0≤x≤3 mol %) are bioactive and biocompatible both in vitro and in vivo 14,24 . It is well reported that magnesium slows down the crystallization of the apatite layer 16,17 , however, in this work we report the formation of an apatitelike phase after 1 h of soaking in SBF as it can be seen in Figure 3.…”

Section: Resultsmentioning

confidence: 99%

Physicochemical and in vitro bioactivity studies of bioactive glasses in the SiO2-CaO-MgO-P2O5, SiO2-Na2O-CaO-P2O5 and SiO2-Na2O-CaO-MgO-P2O5 systems

et al. 2020

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Glasses in the quaternary and quinary system SiO2-CaO-MgO-P2O5 (SCMP), SiO2-Na2O-CaO-P2O5 (SNCP) and SiO2-Na2O-CaO-MgO-P2O5 (SNCMP), have been prepared by using the sol-gel technique. Investigations of structural and bioactive properties of these glasses have been undertaken by using X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray Spectroscopy (EDS). The in vitro bioactivity was assessed by determining the changes in surface morphology and composition after soaking in simulated body fluid (SBF) for up to 30 days at 37°C. X-ray diffraction patterns indicated the formation of hydroxycarbonated apatite layer (HCA) after only one hour for SNCMP glass and after four days for SCMP and SNCP glasses. Furthermore, observed bands of FTIR spectra confirmed the growth of HCA layer during in vitro test.Moreover, the dissolution rate has been investigated using energy-dispersive X-ray spectroscopy. The observed EDS patterns confirmed the growth of HCA layer on all samples surfaces during in vitro analysis. On the one hand, we report the existence of Na2Ca2Si3O9 (that couple good mechanical strength with satisfactory biodegradability) as a single crystalline phase in the SNCP glass when calcined at 600°C. On the other hand, we have noticed that the coexistence of magnesium and sodium both enhanced the dissolution rate and hindered the crystallization in the SNCMP glass at 600°C.

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Section: Resultsmentioning

confidence: 99%

Physicochemical and in vitro bioactivity studies of bioactive glasses in the SiO2-CaO-MgO-P2O5, SiO2-Na2O-CaO-P2O5 and SiO2-Na2O-CaO-MgO-P2O5 systems

et al. 2020

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“…If the problem is due to drug, disease, or life style, it is resolved by the pharmacist himself. Hand book of Pharmaceutical Care by WHO-FIP is advocating the implementation of pharmaceutical [14][15][16] care as a system of health care delivery.…”

Section: Pharmaceutical Career-a Patient Carementioning

confidence: 99%

Challenges in management of prescriptions for patient-centric care

Nagappa

Chikkamath

Naik

et al. 2018

MOJBB

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The paradigm changes from the product-centric market to patient1 centric care are a revolutionary change in health care delivery. The Federation of International Pharmacy (FIP), WHO, and all most all drug regulatory authorities of the developed countries are emphasizing on the importance of patient centric care and outcome research to measure quality of life of the patients. The governments are encouraging the health care providers for focusing on the patient care by providing the direct incentivizes on the other hand, health insurance companies are also putting pressure on health care providers to minimize the cost on medication by adapting to generic prescribing. In developing 2 countries, although the government has realized the importance of patient centric care, they are also emphasizing to set the house in order by bringing various laws and regulations for example Pharmacy Practice Regulations 2015. In this manner they are bringing out fundamental changes in implementing the existing laws and enacting the new laws in regulations to improve the quality of life of patients. In this article we discuss the trends and their impact on clinical, humanistic and economic outcomes.

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Enhanced in vivo biocompatibility of magnesia-contained bioactive glasses

Cited by 2 publications

References 14 publications

Physicochemical and in vitro bioactivity studies of bioactive glasses in the SiO2-CaO-MgO-P2O5, SiO2-Na2O-CaO-P2O5 and SiO2-Na2O-CaO-MgO-P2O5 systems

Physicochemical and in vitro bioactivity studies of bioactive glasses in the SiO2-CaO-MgO-P2O5, SiO2-Na2O-CaO-P2O5 and SiO2-Na2O-CaO-MgO-P2O5 systems

Challenges in management of prescriptions for patient-centric care

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