Enhanced in vitro transdermal delivery of caffeine using a temperature- and pH-sensitive nanogel, poly(NIPAM-co-AAc)

Samah, Nor Hayati Abu; Heard, Charles Martin

doi:10.1016/j.ijpharm.2013.05.042

Cited by 55 publications

(37 citation statements)

References 29 publications

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“…Monoresponsive nanogels cannot maintain the controlled drug release effectively, so nanogels with dual-or multi-stimuli responsiveness have attracted widespread attention [50][51][52][53]. Among the multiresponsiveness combinations, pH-temperature dual-sensitivity combinations have been studied with considerable advances.…”

Section: Multistimuli-responsive Nanogelsmentioning

confidence: 99%

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

et al. 2020

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Nanogel-based nanoplatforms have become a tremendously promising system of drug delivery. Nanogels constructed by chemical crosslinking or physical self-assembly exhibit the ability to encapsulate hydrophilic or hydrophobic therapeutics, including but not limited to small-molecule compounds and proteins, DNA/RNA sequences, and even ultrasmall nanoparticles, within their 3D polymer network. The nanosized nature of the carriers endows them with a specific surface area and inner space, increasing the stability of loaded drugs and prolonging their circulation time. Reactions or the cleavage of chemical bonds in the structure of drug-loaded nanogels have been shown to trigger the controlled or sustained drug release. Through the design of specific chemical structures and different methods of production, nanogels can realize diverse responsiveness (temperature-sensitive, pH-sensitive and redox-sensitive), and enable the stimuli-responsive release of drugs in the microenvironments of various diseases. To improve therapeutic outcomes and increase the precision of therapy, nanogels can be modified by specific ligands to achieve active targeting and enhance the drug accumulation in disease sites. Moreover, the biomembrane-camouflaged nanogels exhibit additional intelligent targeted delivery features. Consequently, the targeted delivery of therapeutic agents, as well as the combinational therapy strategy, result in the improved efficacy of disease treatments, though the introduction of a multifunctional nanogel-based drug delivery system.

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Section: Multistimuli-responsive Nanogelsmentioning

confidence: 99%

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

et al. 2020

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“…24 The application of NIPAM microgels for dermal drug delivery has been investigated with interesting results; however there is still a limited understanding of the behavior of these nanoparticles at the interfaces and the study of the interactions with lipid layers. [25][26][27][28][29][30] Previous work in our group demonstrated that 31 NIPAM-based nanogels form collapsed monolayers at the air-water interfaces, and the thickness of the layer increases with the rigidity of the polymers as a result of higher crosslinker content.…”

Section: Introductionmentioning

confidence: 97%

Interaction of thermal responsive NIPAM nanogels with model lipid monolayers at the air-water interface

Sun

Resmini

Zarbakhsh

2018

Journal of Colloid and Interface Science

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Understanding the interaction of nanoparticles (NP) with ceramide lipids is important in developing strategies to overcome the formidable obstacle that is skin. This paper presents studies of interactions between N-isopropylacrylamide nanogels, crosslinked with 30% N,N'-methylenebisacrylamide, and model ceramide lipid monolayers at the air-water interface as a function of temperature. In the case of the mixed ceramide/cholesterol/behenic acid monolayer, the interaction of nanogels with the ceramide was strongly mediated by the fatty acids. This interaction between nanogels and monolayer components is dominated by hydrophobic-hydrophobic binding. The data show the important intermediary role of the fatty acid in facilitating transmembrane transport. For a pure ceramide lipid monolayer, the neutron reflectivity (NR), Brewster angle microscopy (BAM) and surface pressure results showed a lipid-nanogel complex formation and the subsequent depletion/solubilisation of the lipids from the interface when the area per molecule for the lipid was increased from 42 to 44 Å.

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“…For example, Samah et al [131] used temperature-and pH-sensitive nanogels prepared using PNIPAAm-co-acrylic acid encapsulated with caffeine for transdermal drug delivery. It was observed that these particles tend to collapse at an LCST of 32 C thereby releasing the core compound.…”

Section: Dual-responsive Particlesmentioning

confidence: 99%