Enhanced in vitro biocompatibility of ultrafine-grained titanium with hierarchical porous surface

Zheng, Chaoyue; Nie, Fei; Zheng, Yunfei; Cheng, Yan; Wei, Shicheng; Valiev, Ruslan Z.

doi:10.1016/j.apsusc.2011.01.062

Cited by 58 publications

(37 citation statements)

References 28 publications

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“…It is well known that commercial pure titanium and Ti-6Al-4V alloy are among the most commonly used materials for biomedical implementation. Although mechanical performance of Ti6Al-4V alloy is more reasonable than pure condition, it unfortunately causes serious concerns because of toxic effects of releasing aluminum and vanadium ions in to the body fluids [8,9]. On the other hand, unfortunately pure titanium has quite low mechanical strength which may limits its application in medical field as compared to the other biomaterials, but the most advantage of this pure metal is that it does not release any toxic ions into the body fluids.…”

Section: Introductionmentioning

confidence: 99%

“…They depicts that although the smallest grain size has been obtained after the eight passes, the highest corrosion resistance is observed after the second pass of ECAPed sample. The biocompatibility of UFG titanium with hierarchical porous surface was investigated by Zheng et al [9]. They concluded that the hierarchical porous surface enhances the in vitro surface biocompatibility of the deformed Ti.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, unfortunately pure titanium has quite low mechanical strength which may limits its application in medical field as compared to the other biomaterials, but the most advantage of this pure metal is that it does not release any toxic ions into the body fluids. Recently, ECAP process has been utilized in order to enhance mechanical properties of materials, hence it is seemed that pressed titanium is suitable for the implant and medical applications [9].…”

Section: Introductionmentioning

confidence: 99%

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Electrochemical behavior of equal channel angular pressed titanium for biomedical application

Göde

Attarilar

Eghbali

et al. 2015

AIP Conference Proceedings

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Abstract. Equal channel angular pressing method is one of the prominent severe plastic deformation techniques to obtain ultrafine grained and even nanostructured metals and alloys by imposing intense plastic strain. As known, pure titanium can be a suitable candidate for biomedical applications because it does not release any toxic ions into the body fluids and also, its biocompatibility properties. The present investigation deals the corrosion behavior of commercial pure titanium before and after ECAP process up to 10 passes by route B C at the 250 °C in the 0.9% NaCl solution. The electrochemical results revealed that the corrosion resistance of titanium sample is improved by adding pass number because of the fabrication of passive oxide layer on the surface of the material. It is found that about 92% reduction at the corrosion rate magnitude and also, approximately 41% improvement at the hardness value have been achieved at the final pass as compared to the annealed condition. Furthermore, it is observed that the passive film on the surface of final pass sample is dense and integral with uniform structure, while the as-received one has some rarefactions and does not have very uniform surface.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Electrochemical behavior of equal channel angular pressed titanium for biomedical application

Göde

Attarilar

Eghbali

et al. 2015

AIP Conference Proceedings

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show abstract

“…The UFG material keeps the advantages of cpTi concerning corrosion resistance, biocompatibility and osseointegration and, at the same time, achieves strength levels comparable to those of Ti alloys thanks to the use of the SPD (Severe Plastic Deformation), Figure 10, for grain refinement [3][4][5][6][51][52][53][54][55][56][57][58][59] .…”

Section: Relevance As a Biomaterialsmentioning

confidence: 99%

Properties and Performance of Ultrafine Grained Titanium for Biomedical Applications

2015

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The use of materials for biomedical applications has become vital to enhance the quality of life and longevity of human beings. Commercially pure titanium (cpTi) and titanium alloys are the most adequate materials for some biomedical applications, but cpTi and the Ti-6Al-4V alloy (Ti G5) have limitations for biomedical application due to low mechanical strength and the possibility of ion release, respectively. In order to address this problem, commercially pure ultrafine grained titanium (UFG Ti) obtained by severe plastic deformation (SPD) has been suggested as a promising alternative for biomedical applications. This thermomechanical process is able to improve the strength of cpTi and titanium alloys while keeping their excellent biocompatibility. The purpose of this review was to compare the mechanical strength of UFG Ti, cpTi and a Ti G5 alloy. In addition, the biological performance of UFG Ti was also evaluated by in vivo testing. Prodigious improvements were seen in surface topography, wettability and in homogeneity of oxide layer. The overall improvements in microstructure provided by ECAP technique coupled with surface etching resulted in a remarkable performance of cpTi alloy for biomedical applications.

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“…However its strength can be elevated through microstructural modification by severe plastic deformation (SPD). Not only strength, but also corrosion resistance and surface cells attachment can be improved by the method of SPD [1][2][3][4][5][6][7][8]. The strength increment is correlated to ultrafine grain size given by Hall-Petch relationship.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Surface Precipitates on Ultrafine-Grained Titanium in Physiological Solution

Zhou

Wang

Zou

2017

Metals

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Enhanced cell adherence to the surface of nanocrystallized commercially pure titanium (CP-Ti) was observed by several authors. However, the understanding of the surface modification of Ti in a physiological solution due to nanocrystallized grain size has not been reached. In this work, equal channel angular pressing (ECAP) was applied to manufacturing ultrafine grained CP-Ti. Martensite and Widmanstatten microstructures were also obtained for comparison. The CP-Ti pieces with different microstructures were subjected to soaking tests in a simulated body fluid. Electrochemical impedance spectroscopy (EIS) measurements, X-ray photoelectron spectroscopy (XPS) and scanning electron microscope (SEM), energy dispersive spectrometer (EDS) were used to characterize the surfaces. The results show the surface precipitates mainly contain Ti, O, Ca and P. The quantity of precipitates on ECAPed CP-Ti is the largest among different specimens corresponded to the observation of the thickest layer formation on ECAPed CP-Ti found by EIS. EDS results show more CaPO and less Ti are included on ECAPed Ti comparing to the deposits on other two types of specimens. Smaller numbers of precipitates and denser film are produced on the surface of the water-quenched CP-Ti. The regeneration kinetics of the CaP precipitates evaluated by Gibbs free energy is introduced to interpret the precipitating behaviors on different CP-Ti specimens.

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Enhanced in vitro biocompatibility of ultrafine-grained titanium with hierarchical porous surface

Cited by 58 publications

References 28 publications

Electrochemical behavior of equal channel angular pressed titanium for biomedical application

Electrochemical behavior of equal channel angular pressed titanium for biomedical application

Properties and Performance of Ultrafine Grained Titanium for Biomedical Applications

Enhanced Surface Precipitates on Ultrafine-Grained Titanium in Physiological Solution

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