Enhanced imaging properties of a GdIII complex with unusually large relaxivity

Fatin‐Rouge, Nicolas; Tóth, Éva; Reto, Meuli; Bünzli, Jean‐Claude G.

doi:10.1016/j.jallcom.2003.11.125

Cited by 19 publications

(11 citation statements)

References 14 publications

(22 reference statements)

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“…Further experiments have shown that the nanoparticles display good resistance toward exchange with Zn II and no cytotoxicity; on the other hand, kinetic tests show too great a lability, so that the nanoparticles will have to be stabilized before becoming potential contrast agents. 36 Sensitizing the NIR Emission of Ln III Ions. During the past decade, in vivo optical detection of tumors by means of NIR photons has gained momentum because it represents a noninvasive technique, allowing the exploration of deeper tissues, with the investigation range extending from a few millimeters up to 20 cm.…”

Section: The Podand Approachmentioning

confidence: 99%

Benefiting from the Unique Properties of Lanthanide Ions

2005

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The recent upsurge of interest in contrast agents for magnetic resonance imaging, of luminescent chemosensors for medical diagnostic, and lately, for optical imaging of cells has generated an impressive momentum for the coordination and supramolecular chemistry of trivalent lanthanide ions. We shortly review the synthetic methods allowing the introduction of these spherical ions with fascinating optical and magnetic properties into elaborate mono- and polymetallic edifices. We then illustrate these methods by selected examples describing the use of (i) a coronand to produce luminescent liquid crystals, (ii) derivatized calixarenes for 4f-5f element separation, (iii) podates for the production of nanoparticles with high relaxivity and for sensitizing the near-infrared (NIR) emission, and (iv) self-assembly processes for producing functional bimetallic edifices.

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Section: The Podand Approachmentioning

confidence: 99%

Benefiting from the Unique Properties of Lanthanide Ions

2005

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“…As the concentration of the targets may be very low (typically 10 À9 -10 À13 mol g À1 of tissue), it is necessary to reach high concentrations of Gd III chelate with high relaxivity at the site of interest. [11] This goal may be pursued by 1) using polymers containing covalently bound CA units (dendrimers, [12] polymers and polysaccharides, [13][14][15][16][17] poly amino acids and proteins); [18,19] 2) exploiting self-assembly [20][21][22][23][24][25][26][27][28][29] or noncovalent Abstract: Nanosized contrast agents have great potential in magnetic resonance molecular imaging applications for clinical diagnosis. This study proposes new nanoparticles spontaneously formed under mild conditions and composed of a noncovalent adduct between a gadolinium complex, a polymer of b-cyclodextrin (pbCD: MW 1.5 10 6 g mol À1 ) and a dextran grafted with alkyl chains (MD).…”

Section: Introductionmentioning

confidence: 99%

High‐Relaxivity Magnetic Resonance Imaging (MRI) Contrast Agent Based on Supramolecular Assembly between a Gadolinium Chelate, a Modified Dextran, and Poly‐β‐Cyclodextrin

Battistini¹,

Gianolio²,

Gref³

et al. 2008

Chemistry A European J

100

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Nanosized contrast agents have great potential in magnetic resonance molecular imaging applications for clinical diagnosis. This study proposes new nanoparticles spontaneously formed under mild conditions and composed of a noncovalent adduct between a gadolinium complex, a polymer of beta-cyclodextrin (pbetaCD: MW 1.5 x 10(6) g mol(-1)) and a dextran grafted with alkyl chains (MD). The formation of this supramolecular nanoassembly is based upon a "lock-and-key" recognition process in which the hydrophobic alkyl chains of MD and the adamantyl moieties of macrocyclic Gd(III) chelates are included in the cavities of pbetaCD. The large number of betaCDs contained in the pbetaCD resulted in the formation of 200 nm diameter nanoparticles, each entrapping 1.8 x 10(5) molecules of a low-molecular-weight Gd complex. This system, which exhibits a great relaxivity enhancement (48.4 mM(-1) s(-1), at 20 MHz and 37 degrees C) compared to the Gd(III) chelate itself (5.2 mM(-1) s(-1)), appears to be a promising strategy for the in vivo targeted delivery of Gd(III) complexes. The mechanisms of particle formation, conjugation strategies, and relaxometric characterizations in the field of contrast-enhanced magnetic resonance imaging are discussed.

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“…They distribute mainly into the intravascular and interstitial space, and although they are deemed to be non-specific, they can accumulate within the kidneys due to glomerular filtration. 46 The next generation of contrast agents are designed to be more specific and more effective, with an unusually high relaxivity, 47 greater thermodynamic stability and a more favourable rate of excretion. This can be achieved by attaching the contrast agent to larger structures such as dendrimers 48 or micelles.…”

Section: Figure 10mentioning

confidence: 99%

Development of novel oligomer-based intravascular contrast agents for MRI using gadolinium chelates

Kittigowittana¹

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First of all, I wish to express my deepest and sincere gratitude to my supervisor, Asst. Prof. Roderick W. Bates for his supervision, meaningful guidance, invaluable suggestions, kindness and encouragement throughout my study. This accomplishment would not be possible without his help. I also would like to express my gratitude to Dr Yang Chang-Tong for his collaboration in bioactivities testing and excellent comments. My appreciation is also extended to the staff of the Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, particularly Miss Goh Ee-Ling, Miss Yeo Siew-Ping, and Ms Zhu Wen-Wei for their guidance about recording spectral data and also Dr. Li Yongxin for X-ray crystal structure analysis. I would like to thank all of my friends and colleagues, especially in the Bates group for their warm relationship and kind cooperation. I am grateful to Nanyang Technological University and A*Star (Agency for Science, Technology and Research) through SBIC for financial support. Finally, I am deeply grateful to my parents, my sister and brothers for their invaluable love, encouragement and long-term support. To all of them, I would like to give my gratitude and thanks again.

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Enhanced imaging properties of a GdIII complex with unusually large relaxivity

Cited by 19 publications

References 14 publications

Benefiting from the Unique Properties of Lanthanide Ions

Benefiting from the Unique Properties of Lanthanide Ions

High‐Relaxivity Magnetic Resonance Imaging (MRI) Contrast Agent Based on Supramolecular Assembly between a Gadolinium Chelate, a Modified Dextran, and Poly‐β‐Cyclodextrin

Development of novel oligomer-based intravascular contrast agents for MRI using gadolinium chelates

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