Enhanced Hepatic Lipid Peroxidation in Patients With Primary Biliary Cirrhosis

Kawamura, Kinya; Kobayashi, Yoshimasa; Kageyama, Fujito; Kawasaki, Tsunehisa; Nagasawa, Maho; Toyokuni, Shinya; Uchida, Kôji; Nakamura, Hirotoshi

doi:10.1111/j.1572-0241.2000.03300.x

Cited by 41 publications

(12 citation statements)

References 24 publications

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“…Evidence of oxidative stress has been reported in cholestatic liver disease such as in primary biliary cirrhosis patients (Kawamura et al, 2000) and in BDL animal models ( Barón et al, 1999;Uchinami et al, 2006), and it is often associated with decreased antioxidant defenses. We observed enhanced lipid peroxidation 5 days after BDL (Fig.…”

Section: Discussionmentioning

confidence: 99%

Tetrathiomolybdate Protects against Bile Duct Ligation-Induced Cholestatic Liver Injury and Fibrosis

Song¹,

Song²,

Barve³

et al. 2008

J Pharmacol Exp Ther

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Section: Discussionmentioning

confidence: 99%

Tetrathiomolybdate Protects against Bile Duct Ligation-Induced Cholestatic Liver Injury and Fibrosis

Song¹,

Song²,

Barve³

et al. 2008

J Pharmacol Exp Ther

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“…32 Similarly, the transitional metal ion iron is associated with chronic liver disease as a result of primary iron overload in hereditary hemochromatosis in humans 46 but also accumulates in chronic liver disease associated with hepatitis C virus 59 and alcohol-related liver disease. 50 The effects of nitric oxide (NO) on hepatocytes are complex and dependent on physiologic context; by itself, NO has been demonstrated to be antiapoptotic for hepatocytes, 11,25,[33][34][35]38,63 but with concurrent oxidative stress, NO potentiates hepatocellular necrosis through the evolution of peroxynitrite, a highly reactive oxygen species that can damage a broad variety of organic molecules producing nitrotyrosine-protein adducts.…”

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confidence: 99%

Hepatic Injury Correlates With Apoptosis, Regeneration, and Nitric Oxide Synthase Expression in Canine Chronic Liver Disease

et al. 2013

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Assessment of the clinical severity, pathogenesis, and prognosis of canine chronic liver disease poses significant challenges to clinicians and pathologists, relating in part to a lack of standardized terminology and assessment methods and also to a lack of understanding of the pathogenesis of chronic liver disease in the dog. This study graded the severity of necroinflammatory activity in chronic liver disease in dogs using a modification of Ishak's grading scheme for human chronic liver disease and examined the association of grade score with hepatocellular apoptosis, regeneration, nitric oxide synthase isoform expression, copper and iron accumulation, and indicators of oxidative stress. Formalin-fixed, paraffin-embedded hematoxylin and eosin (HE)-stained liver biopsies from 45 dogs with chronic liver disease and 55 healthy control dogs were graded for various morphologic components of liver injury and response. The cumulative score for grade of necroinflammatory activity was strongly and significantly correlated with immunoreactive labels for hepatocellular proliferation (Ki-67); apoptosis (cleaved caspase-3); inducible nitric oxide synthase (iNOS) in lobular, portal, and septal stromal cells; endothelial nitric oxide synthase (eNOS) in hepatocytes and lobular, portal, and septal stromal cells; and total stainable hepatic iron. A weaker significant correlation was found between grade and accumulation of hepatocellular copper. No significant correlation was found between grade and immunoreactivity for malondialdehyde-protein adducts. These results document a method for grading of the severity of necroinflammatory disease in canine liver biopsies and show an association with increased iNOS and eNOS expression.

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“…Free radicals are involved in the regulation of cell proliferation and death, as well as gene expression such as TNF-α, 5'-Nucleotidase, interleukin-1β (IL-1β) and MDA 54 . Evidence indicates that free radicals, oxidative stress, and lipid peroxidation are present in cholestatic damage 55,56 . EE causes changes in the equilibrium between antioxidant and pro-oxidant activity, favoring the latter, since it increased production of hepatic MDA and reduced free-radical-scavenging activities.…”

Section: Fig 1: Effect Of Ferulic Acid On the Histopathology Of Livementioning

confidence: 99%

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2017

IJPSR

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Enhanced Hepatic Lipid Peroxidation in Patients With Primary Biliary Cirrhosis

Abstract: Hepatic lipid peroxidation can occur in PBC and may be an early event in bile duct destruction. At advanced stages of PBC, hepatocellular lipid peroxidation may play a role in hepatocyte injury during cholestasis.

Cited by 41 publications

References 24 publications

Tetrathiomolybdate Protects against Bile Duct Ligation-Induced Cholestatic Liver Injury and Fibrosis

Tetrathiomolybdate Protects against Bile Duct Ligation-Induced Cholestatic Liver Injury and Fibrosis

Hepatic Injury Correlates With Apoptosis, Regeneration, and Nitric Oxide Synthase Expression in Canine Chronic Liver Disease

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