Enhanced hemostatic indices in patients with pulmonary arterial hypertension: An observational study

Platelet Distribution Width and Mean Platelet Volume in Idiopathic Pulmonary Arterial Hypertension

“…In this study, we found that MPV and PDW were significantly higher in patients with IPAH, and they were mildly correlated with pulmonary arterial pressure and pulmonary vascular resistance. These results were consistent with previous studies reported by Can et al [8] and Varol et al [7]. As suggested by Varol et al [7], two possible mechanisms may contribute to the increased platelet activation in PAH.…”

“…Recently, Can et al [7,8] found that MPV was significantly higher in adult patients with idiopathic pulmonary arterial hypertension (IPAH) than in healthy control patients, suggesting that platelet activation may directly impact pathogenesis of PAH. Kaya et al's [9] study also suggested that MPV was significantly higher in patients with atrial septal defect and correlated with systolic pulmonary artery pressure and right ventricular diameter.…”

Mesenchymal stem cell prevention of vascular remodeling in high flow-induced pulmonary hypertension through a paracrine mechanism

“…Pulmonary arterial hypertension, is a condition characterized by an increase in pulmonary vascular resistance, thrombosis formation, pulmonary vascular remodeling [21][22][23][24][25], structural remodeling of the heart [26], right heart dysfunction and widespread loss of pulmonary microvasculature that carries blood from the heart to the lungs. Although in the past ten years, the treatment of PAH had an apparent progress, but the prognosis is still poor.…”

Enhanced platelet activity in atrial septal defect

“…3,4 Published data showed increased platelet activation and aggregation in other causes of pulmonary hypertension. [5][6][7][8][9] Moreover, such enhanced platelet activity was associated with worse functional status and survival in patients with pulmonary hypertension. 7,8 Mean platelet volume (MPV) is an easily measured hematological marker which increases during platelet activation.…”

“…[10][11][12] Increased MPV levels were found in patients with progression of pulmonary vascular disease. 5,13 There is a lack of studies to explore the relationship of MPV and the development of pulmonary vascular disease in ASD patients.…”