Enhanced-heating effect during photoacoustic imaging-guided high-intensity focused ultrasound

Cui, Huizhong; Yang, Xinmai

doi:10.1063/1.3669441

Cited by 20 publications

(14 citation statements)

References 16 publications

(18 reference statements)

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“…This procedure is generally performed with high intensity light, and mostly limited to clear media or sample surfaces. 23,24 Hence the application of this technique is limited in the in vivo applications, where treatments in a certain depth in turbid media are often desired.In a previous study, 25 we reported an enhanced heating effect during photoacoustic imaging-guided HIFU therapy. The results suggested that cavitation was enhanced when a diagnostic laser light beam illuminated the sample concurrently with HIFU radiation.…”

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confidence: 99%

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Laser-enhanced cavitation during high intensity focused ultrasound: An in vivo study

Cui

Zhang²,

Yang³

2013

Applied Physics Letters

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Laser-enhanced cavitation during high intensity focused ultrasound (HIFU) was studied in vivo using a small animal model. Laser light was employed to illuminate the sample concurrently with HIFU radiation. The resulting cavitation was detected with a passive cavitation detector. The in vivo measurements were made under different combinations of HIFU treatment depths, laser wavelengths, and HIFU durations. The results demonstrated that concurrent light illumination during HIFU has the potential to enhance cavitation effect by reducing cavitation threshold in vivo. High intensity focused ultrasound (HIFU) is a truly noninvasive thermal-ablation technique. HIFU works through rapidly depositing high intensity ultrasound energy into a small region to induce cell death primarily by hyperthermia after high intensity ultrasound is absorbed by soft tissue. [1][2][3][4][5] While the application of HIFU therapy is expanding, one concern related to HIFU treatment is the prolonged treatment time for large tumors because HIFU lesion is relatively small for each HIFU shot.Cavitation has been shown to yield elevated heating rate above those produced by classical acoustic absorption in tissue and can provide an effective method to improve the efficiency of HIFU treatment.6-12 However, pre-existing nucleation sites for cavitation are not omnipresent in most tissues in vivo. Many research efforts have been made to create nucleation sites for cavitation and reduce cavitation threshold. Both ultrasound contrast agents (UCAs) [13][14][15][16][17][18] and nanoparticles have been studied as methods to deliver cavitation nuclei into the targeted region.19,20 The use of UCA or nanoparticles, however, requires the systematic injection of foreign particles into the blood stream, and would have major concerns regarding toxicity, efficiency, etc. Cavitation bubbles can also be induced in presonication areas by using low frequency, high intensity ultrasound prior to HIFU treatments. 21,22 This technique can enhance cavitation and create larger size lesions in deep tissue without the injection of any contrast agents. However, this technique requires very high acoustic pressure (generally more than 10 MPa) to be delivered into soft tissues in order to induce cavitation in the beginning. In addition, the inception of cavitation is erratic and difficult to predict when induced by ultrasound alone.Laser light has been widely used as a reliable method to induce cavitation through optical breakdown. This procedure is generally performed with high intensity light, and mostly limited to clear media or sample surfaces. 23,24 Hence the application of this technique is limited in the in vivo applications, where treatments in a certain depth in turbid media are often desired.In a previous study, 25 we reported an enhanced heating effect during photoacoustic imaging-guided HIFU therapy. The results suggested that cavitation was enhanced when a diagnostic laser light beam illuminated the sample concurrently with HIFU radiation. Two features were highlighted...

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mentioning

confidence: 99%

“…In a previous study, 25 we reported an enhanced heating effect during photoacoustic imaging-guided HIFU therapy. The results suggested that cavitation was enhanced when a diagnostic laser light beam illuminated the sample concurrently with HIFU radiation.…”

mentioning

confidence: 99%

Laser-enhanced cavitation during high intensity focused ultrasound: An in vivo study

Cui

Zhang²,

Yang³

2013

Applied Physics Letters

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“…We have shown in our previous study 23 that laser enhanced HIFU treatment can be used in soft tissue thermal ablation. In this study, the results implied that this technique has successfully shown another potential application in the thrombolysis field.…”

Section: Discussionmentioning

confidence: 99%

“…However, the use of microbubbles and thrombolytic drugs requires the systematic injection of foreign particles into the blood stream, and would have a lot concerns regarding the toxicity, efficiency, etc. 22 In our recent study, 23 we found that when the laser system of photoacoustic imaging (PAI) was running simultaneously with HIFU treatment, an enhanced heating effect can be observed due to enhanced cavitation effects at a relatively low HIFU a) Author to whom correspondence should be addressed.…”

Section: Introductionmentioning

confidence: 99%

Laser enhanced high-intensity focused ultrasound thrombolysis: An in vitro study

Cui¹,

Yang²

2013

The Journal of the Acoustical Society of America

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Laser-enhanced thrombolysis by high intensity focused ultrasound (HIFU) treatment was studied in vitro with bovine blood clots. To achieve laser-enhanced thrombolysis, laser light was employed to illuminate the sample concurrently with HIFU radiation, and ultrasound and laser parameters were optimized to achieve better thrombolysis efficiency. The results indicated that the thrombolysis efficiency increased when pulse length of HIFU wave, HIFU pressure, or laser fluence increases. Also, with the presence of laser, an enhanced effect of thrombolysis was observed.

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“…Laser-induced cavitation has been used for a broad range of applications (Ibrahimkutty et al 2012;Lohse 1998;Frenz et al 1996). Recently, Cui and Yang (2011) reported a heat enhancement effect during photoacoustic imaging (PAI)-guided HIFU therapy. PAI is an emerging non-ionizing and noninvasive imaging technology based on the photoacoustic effect, and it has high optical contrast and excellent spatial resolution (Xu and Wang 2006).…”

Section: Laser-enhanced Ablationmentioning

confidence: 99%

Cavitation Control and Applications

Qiao

Nan

et al. 2015

Cavitation in Biomedicine

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Keywords Effect of acoustic parameters Á Effect of ambient temperature and pressure Á Constrained cavitation Á Spatial and temporal control Á Cavitation dosage control IntroductionCavitation is an important phenomenon that can occur both during diagnostic and therapeutic applications. It is not only an indicator of the transient high pressure and temperature induced by intense bubble collapse, but it also mediates mechanical and thermal effects. As far as mechanical effects, collapsing bubbles can emit shock waves and liquid jets, which are considered the main mechanisms that cause mechanical damage (Kodama and Tomita 2000). Regarding thermal effects, cavitation can enhance heating by confining the acoustic energy within the cavitation region, and it can also enhance viscous absorption at the bubble surface and generate high-frequency broadband harmonics, which have higher heat absorption coefficients. Therefore, cavitation has great potential to enhance therapeutic effi-

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Enhanced-heating effect during photoacoustic imaging-guided high-intensity focused ultrasound

Cited by 20 publications

References 16 publications

Laser-enhanced cavitation during high intensity focused ultrasound: An in vivo study

Laser-enhanced cavitation during high intensity focused ultrasound: An in vivo study

Laser enhanced high-intensity focused ultrasound thrombolysis: An in vitro study

Cavitation Control and Applications

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