2004
DOI: 10.1038/sj.onc.1208181
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Enhanced growth of human met-expressing xenografts in a new strain of immunocompromised mice transgenic for human hepatocyte growth factor/scatter factor

Abstract: Downstream signaling that results from the interaction of hepatocyte growth factor/scatter factor (HGF/SF) with the receptor tyrosine kinase Met plays critical roles in tumor development, progression, and metastasis. This ligand-receptor pair is an attractive target for new diagnostic and therapeutic agents, preclinical development of which requires suitable animal models. The growth of heterotopic and orthotopic Met-expressing human tumor xenografts in conventional strains of immunocompromised mice inadequate… Show more

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Cited by 69 publications
(77 citation statements)
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References 15 publications
(20 reference statements)
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“…2E). However, the activation appeared weaker than that observed in other cancer models we have tested in this system (23,36), and showed little response to MET inhibitors after 3 wk of dosing. MET amplification has also been found in non-small cell lung cancer patients resistant to EGFR inhibitors (24).…”
Section: Discussionmentioning
confidence: 58%
“…2E). However, the activation appeared weaker than that observed in other cancer models we have tested in this system (23,36), and showed little response to MET inhibitors after 3 wk of dosing. MET amplification has also been found in non-small cell lung cancer patients resistant to EGFR inhibitors (24).…”
Section: Discussionmentioning
confidence: 58%
“…3F). At doses ≥30 mg/kg, tumor volumes were static or reduced in size ( Because murine HGF does not activate huMET (38,39), onartuzumab was evaluated in paracrine-driven human xenograft models grown in hHGF tg -C3H-SCID mice (40). The NCI-H596 (MET exon14del ) NSCLC cell line harbors a deletion in exon 14 of the MET gene.…”
Section: Resultsmentioning
confidence: 99%
“…356231; BD Biosciences) inoculated s.c. in the rear right flank of nude (nu/nu) mice. The NCI-H596 tumor model was performed as described previously (40,54). Briefly, 2 × 10 6 NCI-H596 tumor cells were inoculated s.c. in the shaved right rear flank or hHGF Tg -C3H-SCID or littermate C3H-SCID mice.…”
Section: Discussionmentioning
confidence: 99%
“…(iii) Factors important for supporting NCC proliferation and migration may be species-specific, causing the mouse environment to be suboptimal for hNCCs. The use of humanized host embryos that express human growth factors may enhance chimera formation from the human donor cells (25).…”
Section: Discussionmentioning
confidence: 99%