Enhanced gold nanoparticle-tumor cell recognition by albumin multilayer coating

Achilli, Estefanía Edith; Flores, Constanza; Temprana, C. Facundo; Alonso, Santiago; Radrizzani, Martı́n; Grasselli, Mariano

doi:10.1016/j.onano.2021.100033

Cited by 13 publications

(14 citation statements)

References 49 publications

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“…Kulhari and co-workers exploited it in combination with biodegradable poly(lactic-co-glycolic acid) (PLGA) nanoparticles to successfully target both breast and prostate cancer cells and improve docetaxel (DTX) anticancer activity [13][14][15]. The same ligand was also used to target the [ 64 Cu]CuS nanoparticles toward prostate cancer by Cai et al [16]. Interestingly, using native bombesin, Du and Li investigated if the synthetic strategy, namely pre/post-functionalization of nanostructured lipid carriers, affects the performance of the nanosystem for targeted lung cancer combination therapy [17].…”

Section: Targeting Ligandsmentioning

confidence: 99%

“…In some instances, the application of a linker is necessary due to the configuration of functional groups present in both ligand and particle; both homo-and heterobifunctional linkers are available. For example, Achilli et al used glutaraldehyde as a homobifunctional amine-reactive crosslinker to functionalize human serum albumin (HSA) protein corona of biohybrid gold nanoparticles with [Lys1-Lys3(DOTA)]BBN [64]. Kim et al tethered bombesin ligand to amine-modified poly(ethylene glycol) block of amphiphilic copolymer using a heterobifunctional linker, succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) [65].…”

Section: Ligand Incorporationmentioning

confidence: 99%

“…They again used very small AuNPs and conjugated them with a NIR fluorophore and targeting ligands, although this time, greater emphasis was placed on the functionalization with the chelator (NODAGA). Radiolabeling with 64 Cu was achieved with high radiochemical yield and great stability in vitro. The authors provided an interesting explanation regarding the successful targeted delivery of the construct: since elemental copper binds to the DNA, it causes more cell damage than the nanocarrier-bound Cu, which in turn is retained in cell plasma and does not reach the nucleus.…”

Section: Gold Nanomaterialsmentioning

confidence: 99%

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Nanostrategies for Therapeutic and Diagnostic Targeting of Gastrin-Releasing Peptide Receptor

Rurarz¹,

Bukowczyk²,

Gibka³

et al. 2023

Preprint

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Advances in nanomedicine bring the attention of researchers to the molecular targets which can play a major role in the development of novel therapeutic and diagnostic modalities for cancer management. The choice of a proper molecular target can decide on the efficacy of the treatment and endorse the personalized medicine approach. Gastrin-releasing peptide receptor (GRPR) is a G-protein-coupled membrane receptor, well known to be overexpressed in numerous malignancies including pancreatic, prostate, breast, lung, colon, cervical and gastrointestinal cancers. Therefore, many research groups express a deep interest in targeting GRPR with their nanoformulations. A broad spectrum of the GRPR ligands has been described in the literature, which allows tuning of the properties of the final formulation, particularly in the field of the ligand affinity to the receptor and internalization possibilities. Hereby the recent advances in the field of applications of various nanoplatforms which are able to reach the GRPR expressing cells are reviewed.

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Section: Targeting Ligandsmentioning

confidence: 99%

Section: Ligand Incorporationmentioning

confidence: 99%

Section: Gold Nanomaterialsmentioning

confidence: 99%

See 1 more Smart Citation

Nanostrategies for Therapeutic and Diagnostic Targeting of Gastrin-Releasing Peptide Receptor

Rurarz¹,

Bukowczyk²,

Gibka³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…These are summarized in Table 3 . For example, the crosslinked poly(acrylic acid) (PAA) nanogels prepared from pulse radiolysis has been studied through careful control of particle sizes by absorbed dose and dose rate [ 73 , 74 , 75 , 95 ]. The interpolymer-complex (IPC) nanogels composed of two polymer components is also a promising multifunctional-designed nanostructure [ 76 ].…”

Section: Radiation-based Synthesis Of Nanoparticlesmentioning

confidence: 99%

“…Recently ready-to-use templates for radioactive 198 AuNPs, using biopolymers incorporating tumour-targeted peptides, have been successfully developed for use as nanomedicine agents in molecular imaging and therapy [ 91 ]. It has been proven that core-shell AuNPs can be efficiently synthesized in albumin protein solution under irradiation [ 92 , 93 , 95 ].…”

Section: Radiation-based Synthesis Of Nanoparticlesmentioning

confidence: 99%

IAEA Contribution to Nanosized Targeted Radiopharmaceuticals for Drug Delivery

et al. 2022

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The rapidly growing interest in the application of nanoscience in the future design of radiopharmaceuticals and the development of nanosized radiopharmaceuticals in the late 2000′s, resulted in the creation of a Coordinated Research Project (CRP) by the International Atomic Energy Agency (IAEA) in 2014. This CRP entitled ‘Nanosized delivery systems for radiopharmaceuticals’ involved a team of expert scientist from various member states. This team of scientists worked on a number of cutting-edge areas of nanoscience with a focus on developing well-defined, highly effective and site-specific delivery systems of radiopharmaceuticals. Specifically, focus areas of various teams of scientists comprised of the development of nanoparticles (NPs) based on metals, polymers, and gels, and their conjugation/encapsulation or decoration with various tumor avid ligands such as peptides, folates, and small molecule phytochemicals. The research and development efforts also comprised of developing optimum radiolabeling methods of various nano vectors using diagnostic and therapeutic radionuclides including Tc-99m, Ga-68, Lu-177 and Au-198. Concerted efforts of teams of scientists within this CRP has resulted in the development of various protocols and guidelines on delivery systems of nanoradiopharmaceuticals, training of numerous graduate students/post-doctoral fellows and publications in peer reviewed journals while establishing numerous productive scientific networks in various participating member states. Some of the innovative nanoconstructs were chosen for further preclinical applications—all aimed at ultimate clinical translation for treating human cancer patients. This review article summarizes outcomes of this major international scientific endeavor.

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Manipulation of protein corona for nanomedicines

Li,

Wang,

Zhou

2024

WIREs Nanomed Nanobiotechnol

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Nanomedicines have significantly advanced the development of diagnostic and therapeutic strategies for various diseases, while they still encounter numerous challenges. Upon entry into the human body, nanomedicines interact with biomolecules to form a layer of proteins, which is defined as the protein corona that influences the biological properties of nanomedicines. Traditional approaches have primarily focused on designing stealthy nanomedicines to evade biomolecule adsorption; however, due to the intricacies of the biological environment within body, this method cannot completely prevent biomolecule adsorption. As research on the protein corona progresses, manipulating the protein corona to modulate the in vivo behaviors of nanomedicines has become a research focus. In this review, modern strategies focused on influencing the biological efficacy of nanomedicines in vivo by manipulating protein corona, along with their wide‐ranging applications across diverse diseases are critically summarized, highlighted and discussed. Finally, future directions for this important yet challenging research area are also briefly discussed.This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Emerging Technologies Biology‐Inspired Nanomaterials > Protein and Virus‐Based Structures

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Enhanced gold nanoparticle-tumor cell recognition by albumin multilayer coating

Cited by 13 publications

References 49 publications

Nanostrategies for Therapeutic and Diagnostic Targeting of Gastrin-Releasing Peptide Receptor

Nanostrategies for Therapeutic and Diagnostic Targeting of Gastrin-Releasing Peptide Receptor

IAEA Contribution to Nanosized Targeted Radiopharmaceuticals for Drug Delivery

Manipulation of protein corona for nanomedicines

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