Enhanced Glycation of Hemoglobin and Plasma Proteins Is Associated with Increased Lipid Peroxide Levels in Non-Diabetic Hypertensive Subjects

Sathiyapriya, Viswanathan; Selvaraj, N.; Nandeesha, Hanumanthappa; Bobby, Zachariah; Agrawal, Alpna; Pavithran, Purushothaman

doi:10.1016/j.arcmed.2007.05.008

Cited by 16 publications

(7 citation statements)

References 33 publications

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“…Thus, the functional role of this polymorphism deserves more investigation. In addition, it has been recently shown that glycated hemoglobin levels are higher in hypertension patients in relation to controls subjects [49]. These findings suggest that glycated hemoglobin level may contribute to hypertension development.…”

Section: Discussionmentioning

confidence: 86%

Apolipoprotein A1 gene polymorphisms as risk factors for hypertension and obesity

et al. 2009

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Several polymorphisms in apolipoprotein A1 (APOA1) gene have been associated with metabolic diseases. Increased transcription efficiency was observed in -75A allele carriers compared to -75G allele homozygotes. +83C allele was associated with higher body mass index and waist-to-hip ratio in type II diabetes subjects. -75G/A and +83C/T polymorphisms were analyzed by RFLP-PCR in 334 individuals from a Brazilian elderly cohort. APOA1 polymorphisms were associated with age-related morbidities, as well as with triglycerides, total cholesterol, HDL, VLDL, LDL, creatinine, urea, albumin, glycated hemoglobin and fasting glucose serum levels. Allele frequencies were 0.102 and 0.21, respectively, for -75A and +83T. -75G allele showed significant association with hypertension (P = 0.001). An association between +83C allele and obesity was observed (P = 0.040) and this allele also showed an association with hypertension in the presence of cardiovascular disease (P = 0.047). Moreover, +83T allele was associated with lower glycated hemoglobin values (P = 0.026). To our knowledge, there is no data associating this polymorphism with glycated hemoglobin. Furthermore, individuals carrying AT haplotype have lower risk for developing hypertension (P = 0.0002), while GT haplotype carriers present decreased risk to develop obesity comparing to GC haplotype (P = 0.025). APOA1 polymorphisms analysis may be a useful tool to identify risk factors for subjects and families and clarify the physiopathological role of these polymorphisms in age-related diseases, such as hypertension and obesity.

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Section: Discussionmentioning

confidence: 86%

Apolipoprotein A1 gene polymorphisms as risk factors for hypertension and obesity

et al. 2009

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“…Also the activity of RhoA, a small GTPase involved in vascular contraction, has been described to be increased by glucosamine treatment, most probably via O-GlcNAcylation [12]. Finally, fructosamine, which is generated through non-enzymatic glycation when glucose reacts with the amino group of proteins, has been found to be increased in diabetes and conditions or complications associated with diabetes (e.g., cardiovascular complications, hypertension and sleep apnea) [13]–[16].…”

Section: Discussionmentioning

confidence: 99%

A New Metabolomic Signature in Type-2 Diabetes Mellitus and Its Pathophysiology

et al. 2014

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ObjectiveThe objective of the current study was to find a metabolic signature associated with the early manifestations of type-2 diabetes mellitus.Research Design and MethodModern metabolic profiling technology (MxP™ Broad Profiling) was applied to find early alterations in the plasma metabolome of type-2 diabetic patients. The results were validated in an independent study. Eicosanoid and single inon monitoring analysis (MxP™ Eicosanoid and MxP™ SIM analysis) were performed in subsets of samples.ResultsA metabolic signature including significantly increased levels of glyoxylate as a potential novel marker for early detection of type-2 diabetes mellitus was identified in an initial study (Study1). The signature was significantly altered in fasted diabetic and pre-diabetic subjects and in non-fasted subjects up to three years prior to the diagnosis of type-2 diabetes; most alterations were also consistently found in an independent patient group (Study 2). In Study 2 diabetic and most control subjects suffered from heart failure. In Study 1 a subgroup of diabetic subjects, with a history of use of anti-hypertensive medication further showed a more pronounced increase of glyoxylate levels, compared to a non-diabetic control group when tested in a hyperglycemic state. In the context of a prior history of anti-hypertensive medication, alterations in hexosamine and eicosanoid levels were also found.ConclusionA metabolic signature including glyoxylate was associated with type-2 diabetes mellitus, independent of the fasting status and of occurrence of another major disease. The same signature was also found to be associated with pre-diabetic subjects. Glyoxylate levels further showed a specifically strong increase in a subgroup of diabetic subjects. It could represent a new marker for the detection of medical subgroups of diabetic subjects.

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“…Another previous study including four regions of Europe also showed that this variant influenced insulin and glucose levels after an oral glucose tolerance test (OGTT) [17]. Furthermore, it has been reported that there are higher HbAc1 levels in hypertensive patients in relation to controls [37], as well as a correlation of the CC genotype with higher blood pressure [17]. In an European population, CC genotype carriers presented significant association with higher systolic blood pressure and higher waist-to-hip ratio, which is a measure of obesity [17], suggesting that HbAc1 levels may participate in hypertension development.…”

Section: Discussionmentioning

confidence: 85%

APOA1/A5Variants and Haplotypes as a Risk Factor for Obesity and Better Lipid Profiles in a Brazilian Elderly Cohort

Chen

Furuya

Mazzotti

et al. 2010

Lipids

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Genetic variations in the APOA1/C3/A4/A5 gene cluster have been studied and proposed to be the leading key for susceptibility to cardiovascular diseases and age-associated disorders. We aimed to investigate the associations of rs12721026 (APOA1) and rs1729408 (APOA5) polymorphisms and their haplotypes with some age-related diseases, as well as with lipids and proteins serum levels in a cohort from a Brazilian Elderly Longitudinal Study (EPIDOSO). Genotyping was performed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Statistical analyses were carried out using logistic regression analysis, Student's t-test, and linkage disequilibrium (LD) analysis. Polymorphic allele frequencies were 0.095 and 0.449 for rs12721026 and rs1729408, respectively. The C-allele of rs1729408 was associated with higher high-density lipoprotein (HDL) (P = 0.022) and glycated hemoglobin levels (P = 0.020). We also showed that rs12721026 and rs1729408 were in LD. The GC haplotype, which is composed of the G-allele of rs12721026 and the C-allele of rs1729408, was significantly associated with obesity (P = 0.028), with higher glycated hemoglobin (P = 0.006), and fasting glucose (P = 0.0003) compared to the TT haplotype, which includes the wild-type alleles of both polymorphisms. Moreover, we found an association between the TC haplotype and higher HDL levels (P = 0.0039). This is the first time that haplotypes involving these polymorphisms were evaluated. Our results showed that these polymorphisms were involved in the development of obesity and in alterations of lipids and proteins serum levels in a Brazilian population. The present findings might also clarify the role of these polymorphisms and their haplotypes in lipids and proteins metabolism.

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Enhanced Glycation of Hemoglobin and Plasma Proteins Is Associated with Increased Lipid Peroxide Levels in Non-Diabetic Hypertensive Subjects

Cited by 16 publications

References 33 publications

Apolipoprotein A1 gene polymorphisms as risk factors for hypertension and obesity

Apolipoprotein A1 gene polymorphisms as risk factors for hypertension and obesity

A New Metabolomic Signature in Type-2 Diabetes Mellitus and Its Pathophysiology

APOA1/A5Variants and Haplotypes as a Risk Factor for Obesity and Better Lipid Profiles in a Brazilian Elderly Cohort

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